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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''ADP-ribosylation factor-like protein 3''' is a [[protein]] that in humans is encoded by the ''ARL3'' [[gene]].<ref name="pmid8034651">{{cite journal | vauthors = Cavenagh MM, Breiner M, Schurmann A, Rosenwald AG, Terui T, Zhang C, Randazzo PA, Adams M, Joost HG, Kahn RA | title = ADP-ribosylation factor (ARF)-like 3, a new member of the ARF family of GTP-binding proteins cloned from human and rat tissues | journal = J. Biol. Chem. | volume = 269 | issue = 29 | pages = 18937–42  | date = August 1994 | pmid = 8034651 | pmc =  | doi =  }}</ref><ref name="pmid10072593">{{cite journal | vauthors = Kim HS | title = Assignment of the human ADP-ribosylation factor-like 3 (ARL3) gene to chromosome 10 band q23.3 by radiation hybrid mapping | journal = Cytogenet. Cell Genet. | volume = 83 | issue = 3-4 | pages = 246 | year = 1998 | date = March 1999 | pmid = 10072593 | pmc =  | doi = 10.1159/000015194 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ARL3 ADP-ribosylation factor-like 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=403| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_ARL3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1fzq.
| PDB = {{PDB2|1fzq}}
| Name = ADP-ribosylation factor-like 3
| HGNCid = 694
| Symbol = ARL3
| AltSymbols =; ARFL3
| OMIM = 604695
| ECnumber = 
| Homologene = 48276
| MGIid = 1929699
| GeneAtlas_image1 = PBB_GE_ARL3_202641_at_tn.png
| GeneAtlas_image2 = PBB_GE_ARL3_213433_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}}
| Process = {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 403
    | Hs_Ensembl = ENSG00000138175
    | Hs_RefseqProtein = NP_004302
    | Hs_RefseqmRNA = NM_004311
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 10
    | Hs_GenLoc_start = 104423480
    | Hs_GenLoc_end = 104464180
    | Hs_Uniprot = P36405
    | Mm_EntrezGene = 56350
    | Mm_Ensembl = ENSMUSG00000025035
    | Mm_RefseqmRNA = NM_019718
    | Mm_RefseqProtein = NP_062692
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 46584650
    | Mm_GenLoc_end = 46611692
    | Mm_Uniprot = Q543P7
  }}
}}
'''ADP-ribosylation factor-like 3''', also known as '''ARL3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ARL3 ADP-ribosylation factor-like 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=403| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
ADP-ribosylation factor-like 3 is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL3 binds guanine nucleotides but lacks ADP-ribosylation factor activity.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = ADP-ribosylation factor-like 3 is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL3 binds guanine nucleotides but lacks ADP-ribosylation factor activity.<ref name="entrez">{{cite web | title = Entrez Gene: ARL3 ADP-ribosylation factor-like 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=403| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Adams MD, Kerlavage AR, Fleischmann RD, ''et al.'' |title=Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. |journal=Nature |volume=377 |issue= 6547 Suppl |pages= 3-174 |year= 1995 |pmid= 7566098 |doi=  }}
*{{cite journal  | author=Cavenagh MM, Breiner M, Schurmann A, ''et al.'' |title=ADP-ribosylation factor (ARF)-like 3, a new member of the ARF family of GTP-binding proteins cloned from human and rat tissues. |journal=J. Biol. Chem. |volume=269 |issue= 29 |pages= 18937-42 |year= 1994 |pmid= 8034651 |doi=  }}
*{{cite journal  | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal  | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi=  }}
*{{cite journal  | author=Kim HS |title=Assignment of the human ADP-ribosylation factor-like 3 (ARL3) gene to chromosome 10 band q23.3 by radiation hybrid mapping. |journal=Cytogenet. Cell Genet. |volume=83 |issue= 3-4 |pages= 246 |year= 1999 |pmid= 10072593 |doi=  }}
*{{cite journal  | author=Linari M, Hanzal-Bayer M, Becker J |title=The delta subunit of rod specific cyclic GMP phosphodiesterase, PDE delta, interacts with the Arf-like protein Arl3 in a GTP specific manner. |journal=FEBS Lett. |volume=458 |issue= 1 |pages= 55-9 |year= 1999 |pmid= 10518933 |doi=  }}
*{{cite journal  | author=Hillig RC, Hanzal-Bayer M, Linari M, ''et al.'' |title=Structural and biochemical properties show ARL3-GDP as a distinct GTP binding protein. |journal=Structure |volume=8 |issue= 12 |pages= 1239-45 |year= 2001 |pmid= 11188688 |doi=  }}
*{{cite journal  | author=Van Valkenburgh H, Shern JF, Sharer JD, ''et al.'' |title=ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins. |journal=J. Biol. Chem. |volume=276 |issue= 25 |pages= 22826-37 |year= 2001 |pmid= 11303027 |doi= 10.1074/jbc.M102359200 }}
*{{cite journal  | author=Bartolini F, Bhamidipati A, Thomas S, ''et al.'' |title=Functional overlap between retinitis pigmentosa 2 protein and the tubulin-specific chaperone cofactor C. |journal=J. Biol. Chem. |volume=277 |issue= 17 |pages= 14629-34 |year= 2002 |pmid= 11847227 |doi= 10.1074/jbc.M200128200 }}
*{{cite journal  | author=Hanzal-Bayer M, Renault L, Roversi P, ''et al.'' |title=The complex of Arl2-GTP and PDE delta: from structure to function. |journal=EMBO J. |volume=21 |issue= 9 |pages= 2095-106 |year= 2002 |pmid= 11980706 |doi= 10.1093/emboj/21.9.2095 }}
*{{cite journal  | author=Wistow G, Bernstein SL, Wyatt MK, ''et al.'' |title=Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts. |journal=Mol. Vis. |volume=8 |issue=  |pages= 196-204 |year= 2002 |pmid= 12107411 |doi=  }}
*{{cite journal  | author=Grayson C, Bartolini F, Chapple JP, ''et al.'' |title=Localization in the human retina of the X-linked retinitis pigmentosa protein RP2, its homologue cofactor C and the RP2 interacting protein Arl3. |journal=Hum. Mol. Genet. |volume=11 |issue= 24 |pages= 3065-74 |year= 2003 |pmid= 12417528 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Stelzl U, Worm U, Lalowski M, ''et al.'' |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957-68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
*{{cite journal  | author=Kühnel K, Veltel S, Schlichting I, Wittinghofer A |title=Crystal structure of the human retinitis pigmentosa 2 protein and its interaction with Arl3. |journal=Structure |volume=14 |issue= 2 |pages= 367-78 |year= 2006 |pmid= 16472755 |doi= 10.1016/j.str.2005.11.008 }}
*{{cite journal  | author=Zhou C, Cunningham L, Marcus AI, ''et al.'' |title=Arl2 and Arl3 regulate different microtubule-dependent processes. |journal=Mol. Biol. Cell |volume=17 |issue= 5 |pages= 2476-87 |year= 2006 |pmid= 16525022 |doi= 10.1091/mbc.E05-10-0929 }}
}}
{{refend}}


{{protein-stub}}
ARL3 has been shown to [[Protein-protein interaction|interact]] with [[Protein unc-119 homolog]].<ref name=pmid16169070>{{cite journal | vauthors = Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE | title = A human protein-protein interaction network: a resource for annotating the proteome | journal = Cell | volume = 122 | issue = 6 | pages = 957–68  | date = September 2005 | pmid = 16169070 | doi = 10.1016/j.cell.2005.08.029 }}</ref><ref name=pmid11303027>{{cite journal | vauthors = Van Valkenburgh H, Shern JF, Sharer JD, Zhu X, Kahn RA | title = ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins | journal = J. Biol. Chem. | volume = 276 | issue = 25 | pages = 22826–37  | date = June 2001 | pmid = 11303027 | doi = 10.1074/jbc.M102359200 }}</ref>
{{WikiDoc Sources}}
 
== References ==
{{Reflist}}
 
==External links==
* {{UCSC gene info|ARL3}}
 
== Further reading ==
{{Refbegin | 2}}
* {{cite journal | vauthors = Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O | title = Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence | journal = Nature | volume = 377 | issue = 6547 Suppl | pages = 3–174 | year = 1995 | pmid = 7566098 | doi = <!-- none available --> | url = http://www.columbia.edu/itc/biology/pollack/w4065/client_edit/readings/nature377_3.pdf | format = PDF }}
* {{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction | journal = Anal. Biochem. | volume = 236 | issue = 1 | pages = 107–13 | year = 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }}
* {{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing | journal = Genome Res. | volume = 7 | issue = 4 | pages = 353–8 | year = 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }}
* {{cite journal | vauthors = Linari M, Hanzal-Bayer M, Becker J | title = The delta subunit of rod specific cyclic GMP phosphodiesterase, PDE delta, interacts with the Arf-like protein Arl3 in a GTP specific manner | journal = FEBS Lett. | volume = 458 | issue = 1 | pages = 55–9 | year = 1999 | pmid = 10518933 | doi = 10.1016/S0014-5793(99)01117-5 }}
* {{cite journal | vauthors = Hillig RC, Hanzal-Bayer M, Linari M, Becker J, Wittinghofer A, Renault L | title = Structural and biochemical properties show ARL3-GDP as a distinct GTP binding protein | journal = Structure | volume = 8 | issue = 12 | pages = 1239–45 | year = 2000 | pmid = 11188688 | doi = 10.1016/S0969-2126(00)00531-1 }}
* {{cite journal | vauthors = Van Valkenburgh H, Shern JF, Sharer JD, Zhu X, Kahn RA | title = ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins | journal = J. Biol. Chem. | volume = 276 | issue = 25 | pages = 22826–37 | year = 2001 | pmid = 11303027 | doi = 10.1074/jbc.M102359200 }}
* {{cite journal | vauthors = Bartolini F, Bhamidipati A, Thomas S, Schwahn U, Lewis SA, Cowan NJ | title = Functional overlap between retinitis pigmentosa 2 protein and the tubulin-specific chaperone cofactor C | journal = J. Biol. Chem. | volume = 277 | issue = 17 | pages = 14629–34 | year = 2002 | pmid = 11847227 | doi = 10.1074/jbc.M200128200 }}
* {{cite journal | vauthors = Hanzal-Bayer M, Renault L, Roversi P, Wittinghofer A, Hillig RC | title = The complex of Arl2-GTP and PDE delta: from structure to function | journal = EMBO J. | volume = 21 | issue = 9 | pages = 2095–106 | year = 2002 | pmid = 11980706 | pmc = 125981 | doi = 10.1093/emboj/21.9.2095 }}
* {{cite journal | vauthors = Wistow G, Bernstein SL, Wyatt MK, Ray S, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K | title = Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts | journal = Mol. Vis. | volume = 8 | issue =  | pages = 196–204 | year = 2002 | pmid = 12107411 | doi =  }}
* {{cite journal | vauthors = Grayson C, Bartolini F, Chapple JP, Willison KR, Bhamidipati A, Lewis SA, Luthert PJ, Hardcastle AJ, Cowan NJ, Cheetham ME | title = Localization in the human retina of the X-linked retinitis pigmentosa protein RP2, its homologue cofactor C and the RP2 interacting protein Arl3 | journal = Hum. Mol. Genet. | volume = 11 | issue = 24 | pages = 3065–74 | year = 2002 | pmid = 12417528 | doi = 10.1093/hmg/11.24.3065 }}
* {{cite journal | vauthors = Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE | title = A human protein-protein interaction network: a resource for annotating the proteome | journal = Cell | volume = 122 | issue = 6 | pages = 957–68 | year = 2005 | pmid = 16169070 | doi = 10.1016/j.cell.2005.08.029 }}
* {{cite journal | vauthors = Kühnel K, Veltel S, Schlichting I, Wittinghofer A | title = Crystal structure of the human retinitis pigmentosa 2 protein and its interaction with Arl3 | journal = Structure | volume = 14 | issue = 2 | pages = 367–78 | year = 2006 | pmid = 16472755 | doi = 10.1016/j.str.2005.11.008 }}
* {{cite journal | vauthors = Zhou C, Cunningham L, Marcus AI, Li Y, Kahn RA | title = Arl2 and Arl3 regulate different microtubule-dependent processes | journal = Mol. Biol. Cell | volume = 17 | issue = 5 | pages = 2476–87 | year = 2006 | pmid = 16525022 | pmc = 1446103 | doi = 10.1091/mbc.E05-10-0929 }}
{{Refend}}
 
{{PDB Gallery|geneid=403}}
 
 
{{Gene-10-stub}}

Revision as of 18:15, 29 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

ADP-ribosylation factor-like protein 3 is a protein that in humans is encoded by the ARL3 gene.[1][2][3]

Function

ADP-ribosylation factor-like 3 is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL3 binds guanine nucleotides but lacks ADP-ribosylation factor activity.[3]

Interactions

ARL3 has been shown to interact with Protein unc-119 homolog.[4][5]

References

  1. ↑ Cavenagh MM, Breiner M, Schurmann A, Rosenwald AG, Terui T, Zhang C, Randazzo PA, Adams M, Joost HG, Kahn RA (August 1994). "ADP-ribosylation factor (ARF)-like 3, a new member of the ARF family of GTP-binding proteins cloned from human and rat tissues". J. Biol. Chem. 269 (29): 18937–42. PMID 8034651.
  2. ↑ Kim HS (March 1999). "Assignment of the human ADP-ribosylation factor-like 3 (ARL3) gene to chromosome 10 band q23.3 by radiation hybrid mapping". Cytogenet. Cell Genet. 83 (3–4): 246. doi:10.1159/000015194. PMID 10072593. Check date values in: |year= / |date= mismatch (help)
  3. ↑ 3.0 3.1 "Entrez Gene: ARL3 ADP-ribosylation factor-like 3".
  4. ↑ Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
  5. ↑ Van Valkenburgh H, Shern JF, Sharer JD, Zhu X, Kahn RA (June 2001). "ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins". J. Biol. Chem. 276 (25): 22826–37. doi:10.1074/jbc.M102359200. PMID 11303027.

External links

Further reading


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