AFAP1: Difference between revisions

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{{Infobox_gene}}
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'''Actin filament-associated protein 1''' is a [[protein]] that in humans is encoded by the ''AFAP1'' [[gene]].<ref name="pmid14755689">{{cite journal | vauthors = Qian Y, Gatesman AS, Baisden JM, Zot HG, Cherezova L, Qazi I, Mazloum N, Lee MY, Guappone-Koay A, Flynn DC | title = Analysis of the role of the leucine zipper motif in regulating the ability of AFAP-110 to alter actin filament integrity | journal = J Cell Biochem | volume = 91 | issue = 3 | pages = 602–20 |date=Feb 2004 | pmid = 14755689 | pmc =  | doi = 10.1002/jcb.10725 }}</ref><ref name="pmid11641786">{{cite journal | vauthors = Baisden JM, Gatesman AS, Cherezova L, Jiang BH, Flynn DC | title = The intrinsic ability of AFAP-110 to alter actin filament integrity is linked with its ability to also activate cellular tyrosine kinases | journal = Oncogene | volume = 20 | issue = 45 | pages = 6607–16 |date=Oct 2001 | pmid = 11641786 | pmc =  | doi = 10.1038/sj.onc.1204802 }}</ref><ref name="pmid11607843">{{cite journal | vauthors = Baisden JM, Qian Y, Zot HM, Flynn DC | title = The actin filament-associated protein AFAP-110 is an adaptor protein that modulates changes in actin filament integrity | journal = Oncogene | volume = 20 | issue = 44 | pages = 6435–47 |date=Oct 2001 | pmid = 11607843 | pmc =  | doi = 10.1038/sj.onc.1204784 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: AFAP1 actin filament associated protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=60312| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Actin filament associated protein 1
| HGNCid = 24017
| Symbol = AFAP1
| AltSymbols =; AFAP; AFAP-110
| OMIM = 608252
| ECnumber =
| Homologene = 11009
| MGIid = 1917542
| GeneAtlas_image1 = PBB_GE_AFAP1_203563_at_tn.png
| Function =  
| Component =  
  | Process =  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 60312
    | Hs_Ensembl = ENSG00000196526
    | Hs_RefseqProtein = NP_067651
    | Hs_RefseqmRNA = NM_021638
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 7811341
    | Hs_GenLoc_end = 7992486
    | Hs_Uniprot =   
    | Mm_EntrezGene = 70292
    | Mm_Ensembl = ENSMUSG00000029094
    | Mm_RefseqmRNA = NM_027373
    | Mm_RefseqProtein = NP_081649
    | Mm_GenLoc_db =
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 36210180
    | Mm_GenLoc_end = 36320783
    | Mm_Uniprot =   
  }}
}}
'''Actin filament associated protein 1''', also known as '''AFAP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: AFAP1 actin filament associated protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=60312| accessdate = }}</ref>


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| summary_text = The protein encoded by this gene is a Src binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or other signaling proteins to actin filaments. Two alternative transcripts encoding the same protein have been identified.<ref name="entrez">{{cite web | title = Entrez Gene: AFAP1 actin filament associated protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=60312| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a [[Proto-oncogene tyrosine-protein kinase Src|Src]] binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or other signaling proteins to actin filaments. Two alternative transcripts encoding the same protein have been identified.<ref name="entrez"/>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|AFAP1}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Baisden JM, Qian Y, Zot HM, Flynn DC |title=The actin filament-associated protein AFAP-110 is an adaptor protein that modulates changes in actin filament integrity. |journal=Oncogene |volume=20 |issue= 44 |pages= 6435-47 |year= 2001 |pmid= 11607843 |doi= 10.1038/sj.onc.1204784 }}
*{{cite journal  | vauthors=Ishida Y, Hadano S, Nagayama T |title=Isolation and characterization of 21 novel expressed DNA sequences from the distal region of human chromosome 4p. |journal=Genomics |volume=22 |issue= 2 |pages= 302–12 |year= 1995 |pmid= 7545969 |doi=10.1006/geno.1994.1388 |display-authors=etal}}
*{{cite journal  | author=Ishida Y, Hadano S, Nagayama T, ''et al.'' |title=Isolation and characterization of 21 novel expressed DNA sequences from the distal region of human chromosome 4p. |journal=Genomics |volume=22 |issue= 2 |pages= 302-12 |year= 1995 |pmid= 7545969 |doi=  }}
*{{cite journal  | vauthors=Qian Y, Baisden JM, Westin EH |title=Src can regulate carboxy terminal interactions with AFAP-110, which influence self-association, cell localization and actin filament integrity. |journal=Oncogene |volume=16 |issue= 17 |pages= 2185–95 |year= 1998 |pmid= 9619827 |doi= 10.1038/sj.onc.1201753 |display-authors=etal}}
*{{cite journal  | author=Qian Y, Baisden JM, Westin EH, ''et al.'' |title=Src can regulate carboxy terminal interactions with AFAP-110, which influence self-association, cell localization and actin filament integrity. |journal=Oncogene |volume=16 |issue= 17 |pages= 2185-95 |year= 1998 |pmid= 9619827 |doi= 10.1038/sj.onc.1201753 }}
*{{cite journal  | vauthors=Guappone AC, Weimer T, Flynn DC |title=Formation of a stable src-AFAP-110 complex through either an amino-terminal or a carboxy-terminal SH2-binding motif. |journal=Mol. Carcinog. |volume=22 |issue= 2 |pages= 110–9 |year= 1998 |pmid= 9655255 |doi=10.1002/(SICI)1098-2744(199806)22:2<110::AID-MC6>3.0.CO;2-Q }}
*{{cite journal  | author=Guappone AC, Weimer T, Flynn DC |title=Formation of a stable src-AFAP-110 complex through either an amino-terminal or a carboxy-terminal SH2-binding motif. |journal=Mol. Carcinog. |volume=22 |issue= 2 |pages= 110-9 |year= 1998 |pmid= 9655255 |doi=  }}
*{{cite journal  | vauthors=Qian Y, Baisden JM, Zot HG |title=The carboxy terminus of AFAP-110 modulates direct interactions with actin filaments and regulates its ability to alter actin filament integrity and induce lamellipodia formation. |journal=Exp. Cell Res. |volume=255 |issue= 1 |pages= 102–13 |year= 2000 |pmid= 10666339 |doi= 10.1006/excr.1999.4795 |display-authors=etal}}
*{{cite journal  | author=Qian Y, Baisden JM, Zot HG, ''et al.'' |title=The carboxy terminus of AFAP-110 modulates direct interactions with actin filaments and regulates its ability to alter actin filament integrity and induce lamellipodia formation. |journal=Exp. Cell Res. |volume=255 |issue= 1 |pages= 102-13 |year= 2000 |pmid= 10666339 |doi= 10.1006/excr.1999.4795 }}
*{{cite journal  | vauthors=Qian Y, Baisden JM, Cherezova L |title=PC phosphorylation increases the ability of AFAP-110 to cross-link actin filaments. |journal=Mol. Biol. Cell |volume=13 |issue= 7 |pages= 2311–22 |year= 2003 |pmid= 12134071 |doi= 10.1091/mbc.E01-12-0148 | pmc=117315 |display-authors=etal}}
*{{cite journal  | author=Baisden JM, Gatesman AS, Cherezova L, ''et al.'' |title=The intrinsic ability of AFAP-110 to alter actin filament integrity is linked with its ability to also activate cellular tyrosine kinases. |journal=Oncogene |volume=20 |issue= 45 |pages= 6607-16 |year= 2001 |pmid= 11641786 |doi= 10.1038/sj.onc.1204802 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Qian Y, Baisden JM, Cherezova L, ''et al.'' |title=PC phosphorylation increases the ability of AFAP-110 to cross-link actin filaments. |journal=Mol. Biol. Cell |volume=13 |issue= 7 |pages= 2311-22 |year= 2003 |pmid= 12134071 |doi= 10.1091/mbc.E01-12-0148 }}
*{{cite journal  | vauthors=Brandenberger R, Wei H, Zhang S |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Ballif BA, Villén J, Beausoleil SA |title=Phosphoproteomic analysis of the developing mouse brain. |journal=Mol. Cell. Proteomics |volume=3 |issue= 11 |pages= 1093–101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200 |display-authors=etal}}
*{{cite journal | author=Qian Y, Gatesman AS, Baisden JM, ''et al.'' |title=Analysis of the role of the leucine zipper motif in regulating the ability of AFAP-110 to alter actin filament integrity. |journal=J. Cell. Biochem. |volume=91 |issue= 3 |pages= 602-20 |year= 2004 |pmid= 14755689 |doi= 10.1002/jcb.10725 }}
*{{cite journal  | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
*{{cite journal  | author=Brandenberger R, Wei H, Zhang S, ''et al.'' |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707-16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal  | vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |display-authors=etal}}
*{{cite journal  | author=Ballif BA, Villén J, Beausoleil SA, ''et al.'' |title=Phosphoproteomic analysis of the developing mouse brain. |journal=Mol. Cell Proteomics |volume=3 |issue= 11 |pages= 1093-101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200 }}
*{{cite journal  | vauthors=Dorfleutner A, Stehlik C, Zhang J |title=AFAP-110 is required for actin stress fiber formation and cell adhesion in MDA-MB-231 breast cancer cells. |journal=J. Cell. Physiol. |volume=213 |issue= 3 |pages= 740–9 |year= 2007 |pmid= 17520695 |doi= 10.1002/jcp.21143 |display-authors=etal}}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal  | author=Dorfleutner A, Stehlik C, Zhang J, ''et al.'' |title=AFAP-110 is required for actin stress fiber formation and cell adhesion in MDA-MB-231 breast cancer cells. |journal=J. Cell. Physiol. |volume=213 |issue= 3 |pages= 740-9 |year= 2007 |pmid= 17520695 |doi= 10.1002/jcp.21143 }}
}}
}}
{{refend}}
{{refend}}


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Revision as of 01:50, 28 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Actin filament-associated protein 1 is a protein that in humans is encoded by the AFAP1 gene.[1][2][3][4]

The protein encoded by this gene is a Src binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or other signaling proteins to actin filaments. Two alternative transcripts encoding the same protein have been identified.[4]

References

  1. ↑ Qian Y, Gatesman AS, Baisden JM, Zot HG, Cherezova L, Qazi I, Mazloum N, Lee MY, Guappone-Koay A, Flynn DC (Feb 2004). "Analysis of the role of the leucine zipper motif in regulating the ability of AFAP-110 to alter actin filament integrity". J Cell Biochem. 91 (3): 602–20. doi:10.1002/jcb.10725. PMID 14755689.
  2. ↑ Baisden JM, Gatesman AS, Cherezova L, Jiang BH, Flynn DC (Oct 2001). "The intrinsic ability of AFAP-110 to alter actin filament integrity is linked with its ability to also activate cellular tyrosine kinases". Oncogene. 20 (45): 6607–16. doi:10.1038/sj.onc.1204802. PMID 11641786.
  3. ↑ Baisden JM, Qian Y, Zot HM, Flynn DC (Oct 2001). "The actin filament-associated protein AFAP-110 is an adaptor protein that modulates changes in actin filament integrity". Oncogene. 20 (44): 6435–47. doi:10.1038/sj.onc.1204784. PMID 11607843.
  4. ↑ 4.0 4.1 "Entrez Gene: AFAP1 actin filament associated protein 1".

External links

Further reading



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