RIT1: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''GTP-binding protein Rit1''' is a [[protein]] that in humans is encoded by the ''RIT1'' [[gene]].<ref name="pmid8824319">{{cite journal | vauthors = Lee CH, Della NG, Chew CE, Zack DJ | title = Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins | journal = The Journal of Neuroscience | volume = 16 | issue = 21 | pages = 6784–94 | date = November 1996 | pmid = 8824319 | pmc =  | doi =  }}</ref><ref name="pmid8918462">{{cite journal | vauthors = Wes PD, Yu M, Montell C | title = RIC, a calmodulin-binding Ras-like GTPase | journal = The EMBO Journal | volume = 15 | issue = 21 | pages = 5839–48 | date = November 1996 | pmid = 8918462 | pmc = 452332 | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RIT1 Ras-like without CAAX 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6016| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Ras-like without CAAX 1
| HGNCid = 10023
| Symbol = RIT1
| AltSymbols =; MGC125864; MGC125865; RIBB; RIT; ROC1
| OMIM = 609591
| ECnumber = 
| Homologene = 56003
| MGIid = 108053
| GeneAtlas_image1 = PBB_GE_RIT1_209882_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005516 |text = calmodulin binding}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6016
    | Hs_Ensembl = ENSG00000143622
    | Hs_RefseqProtein = NP_008843
    | Hs_RefseqmRNA = NM_006912
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 154134223
    | Hs_GenLoc_end = 154147819
    | Hs_Uniprot = Q92963
    | Mm_EntrezGene = 19769
    | Mm_Ensembl = ENSMUSG00000028057
    | Mm_RefseqmRNA = NM_009069
    | Mm_RefseqProtein = NP_033095
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 88802834
    | Mm_GenLoc_end = 88816976
    | Mm_Uniprot = P70426
  }}
}}
'''Ras-like without CAAX 1''', also known as '''RIT1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RIT1 Ras-like without CAAX 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6016| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
RIT belongs to the RAS (HRAS; MIM 190020) subfamily of small GTPases (Hynds et al., 2003).[supplied by OMIM]<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = RIT belongs to the RAS (HRAS; MIM 190020) subfamily of small GTPases (Hynds et al., 2003).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: RIT1 Ras-like without CAAX 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6016| accessdate = }}</ref>
}}


==References==
== Clinical significance ==
{{reflist|2}}
 
==Further reading==
Mutations in RIT1 are associated to {{SWL|type=mutations_associated_to|target=Noonan syndrome|label=Noonan syndrome}}.<ref>{{cite journal | vauthors = Gos M, Fahiminiya S, Poznański J, Klapecki J, Obersztyn E, Piotrowicz M, Wierzba J, Posmyk R, Bal J, Majewski J | title = Contribution of RIT1 mutations to the pathogenesis of Noonan syndrome: four new cases and further evidence of heterogeneity | journal = American Journal of Medical Genetics. Part A | volume = 164A | issue = 9 | pages = 2310–6 | date = September 2014 | pmid = 24939608 | doi = 10.1002/ajmg.a.36646 }}</ref>
 
== Interactions ==
 
RIT1 has been shown to [[Protein-protein interaction|interact]] with [[KLHL12]]<ref name=pmid18303015>{{cite journal | vauthors = Rondou P, Haegeman G, Vanhoenacker P, Van Craenenbroeck K | title = BTB Protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase | journal = The Journal of Biological Chemistry | volume = 283 | issue = 17 | pages = 11083–96 | date = April 2008 | pmid = 18303015 | pmc = 2431063 | doi = 10.1074/jbc.M708473200 }}</ref> and [[Merlin (protein)|Merlin]].<ref name=pmid18332868>{{cite journal | vauthors = Huang J, Chen J | title = VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation | journal = Oncogene | volume = 27 | issue = 29 | pages = 4056–64 | date = July 2008 | pmid = 18332868 | doi = 10.1038/onc.2008.44 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Shao H, Kadono-Okuda K, Finlin BS, Andres DA | title = Biochemical characterization of the Ras-related GTPases Rit and Rin | journal = Archives of Biochemistry and Biophysics | volume = 371 | issue = 2 | pages = 207–19 | date = November 1999 | pmid = 10545207 | doi = 10.1006/abbi.1999.1448 }}
| citations =
* {{cite journal | vauthors = Shao H, Andres DA | title = A novel RalGEF-like protein, RGL3, as a candidate effector for rit and Ras | journal = The Journal of Biological Chemistry | volume = 275 | issue = 35 | pages = 26914–24 | date = September 2000 | pmid = 10869344 | doi = 10.1074/jbc.M002241200 }}
*{{cite journal  | author=Lee CH, Della NG, Chew CE, Zack DJ |title=Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins. |journal=J. Neurosci. |volume=16 |issue= 21 |pages= 6784-94 |year= 1996 |pmid= 8824319 |doi=  }}
* {{cite journal | vauthors = Hynds DL, Spencer ML, Andres DA, Snow DM | title = Rit promotes MEK-independent neurite branching in human neuroblastoma cells | journal = Journal of Cell Science | volume = 116 | issue = Pt 10 | pages = 1925–35 | date = May 2003 | pmid = 12668729 | doi = 10.1242/jcs.00401 }}
*{{cite journal | author=Wes PD, Yu M, Montell C |title=RIC, a calmodulin-binding Ras-like GTPase. |journal=EMBO J. |volume=15 |issue= 21 |pages= 5839-48 |year= 1997 |pmid= 8918462 |doi=  }}
* {{cite journal | vauthors = Li JT, Liu W, Kuang ZH, Zhang RH, Chen HK, Feng QS | title = [Mutation and amplification of RIT1 gene in hepatocellular carcinoma] | journal = Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics | volume = 21 | issue = 1 | pages = 43–6 | date = February 2004 | pmid = 14767908 | doi =  }}
*{{cite journal  | author=Shao H, Kadono-Okuda K, Finlin BS, Andres DA |title=Biochemical characterization of the Ras-related GTPases Rit and Rin. |journal=Arch. Biochem. Biophys. |volume=371 |issue= 2 |pages= 207-19 |year= 1999 |pmid= 10545207 |doi= 10.1006/abbi.1999.1448 }}
* {{cite journal | vauthors = Shi GX, Andres DA | title = Rit contributes to nerve growth factor-induced neuronal differentiation via activation of B-Raf-extracellular signal-regulated kinase and p38 mitogen-activated protein kinase cascades | journal = Molecular and Cellular Biology | volume = 25 | issue = 2 | pages = 830–46 | date = January 2005 | pmid = 15632082 | pmc = 543422 | doi = 10.1128/MCB.25.2.830-846.2005 }}
*{{cite journal | author=Shao H, Andres DA |title=A novel RalGEF-like protein, RGL3, as a candidate effector for rit and Ras. |journal=J. Biol. Chem. |volume=275 |issue= 35 |pages= 26914-24 |year= 2000 |pmid= 10869344 |doi= 10.1074/jbc.M002241200 }}
* {{cite journal | vauthors = Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL | title = High-throughput mapping of a dynamic signaling network in mammalian cells | journal = Science | volume = 307 | issue = 5715 | pages = 1621–5 | date = March 2005 | pmid = 15761153 | doi = 10.1126/science.1105776 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Benmaamar R, Pagano M | title = Involvement of the SCF complex in the control of Cdh1 degradation in S-phase | journal = Cell Cycle | volume = 4 | issue = 9 | pages = 1230–2 | date = September 2005 | pmid = 16123585 | doi = 10.4161/cc.4.9.2048 }}
*{{cite journal  | author=Hynds DL, Spencer ML, Andres DA, Snow DM |title=Rit promotes MEK-independent neurite branching in human neuroblastoma cells. |journal=J. Cell. Sci. |volume=116 |issue= Pt 10 |pages= 1925-35 |year= 2004 |pmid= 12668729 |doi= 10.1242/jcs.00401 }}
*{{cite journal | author=Li JT, Liu W, Kuang ZH, ''et al.'' |title=[Mutation and amplification of RIT1 gene in hepatocellular carcinoma] |journal=Zhonghua Yi Xue Yi Chuan Xue Za Zhi |volume=21 |issue= 1 |pages= 43-6 |year= 2004 |pmid= 14767908 |doi=  }}
*{{cite journal | author=Shi GX, Andres DA |title=Rit contributes to nerve growth factor-induced neuronal differentiation via activation of B-Raf-extracellular signal-regulated kinase and p38 mitogen-activated protein kinase cascades. |journal=Mol. Cell. Biol. |volume=25 |issue= 2 |pages= 830-46 |year= 2005 |pmid= 15632082 |doi= 10.1128/MCB.25.2.830-846.2005 }}
*{{cite journal | author=Barrios-Rodiles M, Brown KR, Ozdamar B, ''et al.'' |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621-5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 }}
*{{cite journal | author=Benmaamar R, Pagano M |title=Involvement of the SCF complex in the control of Cdh1 degradation in S-phase. |journal=Cell Cycle |volume=4 |issue= 9 |pages= 1230-2 |year= 2006 |pmid= 16123585 |doi= }}
}}
{{refend}}
{{refend}}


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{{gene-1-stub}}
{{WikiDoc Sources}}

Latest revision as of 03:59, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

GTP-binding protein Rit1 is a protein that in humans is encoded by the RIT1 gene.[1][2][3]

Function

RIT belongs to the RAS (HRAS; MIM 190020) subfamily of small GTPases (Hynds et al., 2003).[supplied by OMIM][3]

Clinical significance

Mutations in RIT1 are associated to Noonan syndrome .[4]

Interactions

RIT1 has been shown to interact with KLHL12[5] and Merlin.[6]

References

  1. ↑ Lee CH, Della NG, Chew CE, Zack DJ (November 1996). "Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins". The Journal of Neuroscience. 16 (21): 6784–94. PMID 8824319.
  2. ↑ Wes PD, Yu M, Montell C (November 1996). "RIC, a calmodulin-binding Ras-like GTPase". The EMBO Journal. 15 (21): 5839–48. PMC 452332. PMID 8918462.
  3. ↑ 3.0 3.1 "Entrez Gene: RIT1 Ras-like without CAAX 1".
  4. ↑ Gos M, Fahiminiya S, Poznański J, Klapecki J, Obersztyn E, Piotrowicz M, Wierzba J, Posmyk R, Bal J, Majewski J (September 2014). "Contribution of RIT1 mutations to the pathogenesis of Noonan syndrome: four new cases and further evidence of heterogeneity". American Journal of Medical Genetics. Part A. 164A (9): 2310–6. doi:10.1002/ajmg.a.36646. PMID 24939608.
  5. ↑ Rondou P, Haegeman G, Vanhoenacker P, Van Craenenbroeck K (April 2008). "BTB Protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase". The Journal of Biological Chemistry. 283 (17): 11083–96. doi:10.1074/jbc.M708473200. PMC 2431063. PMID 18303015.
  6. ↑ Huang J, Chen J (July 2008). "VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation". Oncogene. 27 (29): 4056–64. doi:10.1038/onc.2008.44. PMID 18332868.

Further reading


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