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{{Infobox_gene}}
{{PBB_Controls
'''T-complex protein 1 subunit gamma''' is a [[protein]] that in humans is encoded by the ''CCT3'' [[gene]].<ref name="pmid8110840">{{cite journal | vauthors = Joly EC, Sévigny G, Todorov IT, Bibor-Hardy V | title = cDNA encoding a novel TCP1-related protein | journal = Biochimica et Biophysica Acta | volume = 1217 | issue = 2 | pages = 224–6 | date = Mar 1994 | pmid = 8110840 | pmc =  | doi = 10.1016/0167-4781(94)90041-8 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CCT3 chaperonin containing TCP1, subunit 3 (gamma)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7203| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_CCT3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1gml.
| PDB = {{PDB2|1gml}}, {{PDB2|1gn1}}
| Name = Chaperonin containing TCP1, subunit 3 (gamma)
| HGNCid = 1616
| Symbol = CCT3
| AltSymbols =; CCT-gamma; CCTG; PIG48; TCP-1-gamma; TRIC5
| OMIM = 600114
| ECnumber = 
| Homologene = 4373
| MGIid = 104708
| GeneAtlas_image1 = PBB_GE_CCT3_200910_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0051082 |text = unfolded protein binding}}
| Component = {{GNF_GO|id=GO:0005832 |text = chaperonin-containing T-complex}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}}
| Process = {{GNF_GO|id=GO:0006457 |text = protein folding}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7203
    | Hs_Ensembl = ENSG00000163468
    | Hs_RefseqProtein = NP_001008800
    | Hs_RefseqmRNA = NM_001008800
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 154545376
    | Hs_GenLoc_end = 154604261
    | Hs_Uniprot = P49368
    | Mm_EntrezGene = 12462
    | Mm_Ensembl = ENSMUSG00000001416
    | Mm_RefseqmRNA = NM_009836
    | Mm_RefseqProtein = NP_033966
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 88383062
    | Mm_GenLoc_end = 88407693
    | Mm_Uniprot = Q3TBM6
  }}
}}
'''Chaperonin containing TCP1, subunit 3 (gamma)''', also known as '''CCT3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CCT3 chaperonin containing TCP1, subunit 3 (gamma)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7203| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a molecular chaperone that is member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a molecular chaperone that is member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.<ref name="entrez">{{cite web | title = Entrez Gene: CCT3 chaperonin containing TCP1, subunit 3 (gamma)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7203| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
CCT3 has been shown to [[Protein-protein interaction|interact]] with [[PPP4C]].<ref name=pmid18715871>{{cite journal | vauthors = Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC | title = PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4 | journal = The Journal of Biological Chemistry | volume = 283 | issue = 43 | pages = 29273–84 | date = Oct 2008 | pmid = 18715871 | pmc = 2662017 | doi = 10.1074/jbc.M803443200 }}</ref><ref name=pmid16085932>{{cite journal | vauthors = Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R | title = A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity | journal = Molecular & Cellular Proteomics | volume = 4 | issue = 11 | pages = 1725–40 | date = Nov 2005 | pmid = 16085932 | doi = 10.1074/mcp.M500231-MCP200 }}</ref>
 
== References ==
{{reflist}}
 
==External links==
* {{UCSC gene info|CCT3}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Kubota H, Hynes G, Carne A, Ashworth A, Willison K | title = Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin | journal = Current Biology | volume = 4 | issue = 2 | pages = 89–99 | date = Feb 1994 | pmid = 7953530 | doi = 10.1016/S0960-9822(94)00024-2 }}
| citations =
* {{cite journal | vauthors = Sévigny G, Joly EC, Bibor-Hardy V, Lemieux N | title = Assignment of the human homologue of the mTRiC-P5 gene (TRIC5) to band 1q23 by fluorescence in situ hybridization | journal = Genomics | volume = 22 | issue = 3 | pages = 634–6 | date = Aug 1994 | pmid = 8001976 | doi = 10.1006/geno.1994.1438 }}
*{{cite journal | author=Kubota H, Hynes G, Carne A, ''et al.'' |title=Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin. |journal=Curr. Biol. |volume=4 |issue= 2 |pages= 89-99 |year= 1994 |pmid= 7953530 |doi= }}
* {{cite journal | vauthors = Walkley NA, Demaine AG, Malik AN | title = Cloning, structure and mRNA expression of human Cctg, which encodes the chaperonin subunit CCT gamma | journal = The Biochemical Journal | volume = 313 | issue = Pt 2 | pages = 381–9 | date = Jan 1996 | pmid = 8573069 | pmc = 1216920 | doi =  10.1042/bj3130381}}
*{{cite journal | author=Sévigny G, Joly EC, Bibor-Hardy V, Lemieux N |title=Assignment of the human homologue of the mTRiC-P5 gene (TRIC5) to band 1q23 by fluorescence in situ hybridization. |journal=Genomics |volume=22 |issue= 3 |pages= 634-6 |year= 1995 |pmid= 8001976 |doi= }}
* {{cite journal | vauthors = Feldman DE, Thulasiraman V, Ferreyra RG, Frydman J | title = Formation of the VHL-elongin BC tumor suppressor complex is mediated by the chaperonin TRiC | journal = Molecular Cell | volume = 4 | issue = 6 | pages = 1051–61 | date = Dec 1999 | pmid = 10635329 | doi = 10.1016/S1097-2765(00)80233-6 }}
*{{cite journal  | author=Joly EC, Sévigny G, Todorov IT, Bibor-Hardy V |title=cDNA encoding a novel TCP1-related protein. |journal=Biochim. Biophys. Acta |volume=1217 |issue= 2 |pages= 224-6 |year= 1994 |pmid= 8110840 |doi=  }}
* {{cite journal | vauthors = Wong N, Chan A, Lee SW, Lam E, To KF, Lai PB, Li XN, Liew CT, Johnson PJ | title = Positional mapping for amplified DNA sequences on 1q21-q22 in hepatocellular carcinoma indicates candidate genes over-expression | journal = Journal of Hepatology | volume = 38 | issue = 3 | pages = 298–306 | date = Mar 2003 | pmid = 12586295 | doi = 10.1016/S0168-8278(02)00412-9 }}
*{{cite journal | author=Walkley NA, Demaine AG, Malik AN |title=Cloning, structure and mRNA expression of human Cctg, which encodes the chaperonin subunit CCT gamma. |journal=Biochem. J. |volume=313 ( Pt 2) |issue= |pages= 381-9 |year= 1996 |pmid= 8573069 |doi=  }}
* {{cite journal | vauthors = Yuryev A, Wennogle LP | title = Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis | journal = Genomics | volume = 81 | issue = 2 | pages = 112–25 | date = Feb 2003 | pmid = 12620389 | doi = 10.1016/S0888-7543(02)00008-3 }}
*{{cite journal | author=Feldman DE, Thulasiraman V, Ferreyra RG, Frydman J |title=Formation of the VHL-elongin BC tumor suppressor complex is mediated by the chaperonin TRiC. |journal=Mol. Cell |volume=4 |issue= 6 |pages= 1051-61 |year= 2000 |pmid= 10635329 |doi= }}
* {{cite journal | vauthors = Reuter TY, Medhurst AL, Waisfisz Q, Zhi Y, Herterich S, Hoehn H, Gross HJ, Joenje H, Hoatlin ME, Mathew CG, Huber PA | title = Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport | journal = Experimental Cell Research | volume = 289 | issue = 2 | pages = 211–21 | date = Oct 2003 | pmid = 14499622 | doi = 10.1016/S0014-4827(03)00261-1 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Imai Y, Soda M, Murakami T, Shoji M, Abe K, Takahashi R | title = A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death | journal = The Journal of Biological Chemistry | volume = 278 | issue = 51 | pages = 51901–10 | date = Dec 2003 | pmid = 14532270 | doi = 10.1074/jbc.M309655200 }}
*{{cite journal | author=Wong N, Chan A, Lee SW, ''et al.'' |title=Positional mapping for amplified DNA sequences on 1q21-q22 in hepatocellular carcinoma indicates candidate genes over-expression. |journal=J. Hepatol. |volume=38 |issue= 3 |pages= 298-306 |year= 2003 |pmid= 12586295 |doi= }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Yuryev A, Wennogle LP |title=Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis. |journal=Genomics |volume=81 |issue= 2 |pages= 112-25 |year= 2003 |pmid= 12620389 |doi= }}
*{{cite journal | author=Reuter TY, Medhurst AL, Waisfisz Q, ''et al.'' |title=Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport. |journal=Exp. Cell Res. |volume=289 |issue= 2 |pages= 211-21 |year= 2003 |pmid= 14499622 |doi= }}
*{{cite journal | author=Imai Y, Soda M, Murakami T, ''et al.'' |title=A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. |journal=J. Biol. Chem. |volume=278 |issue= 51 |pages= 51901-10 |year= 2004 |pmid= 14532270 |doi= 10.1074/jbc.M309655200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=7203}}
{{WikiDoc Sources}}
 
 
{{gene-1-stub}}

Latest revision as of 09:19, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

T-complex protein 1 subunit gamma is a protein that in humans is encoded by the CCT3 gene.[1][2]

Function

This gene encodes a molecular chaperone that is member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[2]

Interactions

CCT3 has been shown to interact with PPP4C.[3][4]

References

  1. ↑ Joly EC, Sévigny G, Todorov IT, Bibor-Hardy V (Mar 1994). "cDNA encoding a novel TCP1-related protein". Biochimica et Biophysica Acta. 1217 (2): 224–6. doi:10.1016/0167-4781(94)90041-8. PMID 8110840.
  2. ↑ 2.0 2.1 "Entrez Gene: CCT3 chaperonin containing TCP1, subunit 3 (gamma)".
  3. ↑ Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (Oct 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry. 283 (43): 29273–84. doi:10.1074/jbc.M803443200. PMC 2662017. PMID 18715871.
  4. ↑ Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (Nov 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Molecular & Cellular Proteomics. 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932.

External links

Further reading

  • Kubota H, Hynes G, Carne A, Ashworth A, Willison K (Feb 1994). "Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin". Current Biology. 4 (2): 89–99. doi:10.1016/S0960-9822(94)00024-2. PMID 7953530.
  • Sévigny G, Joly EC, Bibor-Hardy V, Lemieux N (Aug 1994). "Assignment of the human homologue of the mTRiC-P5 gene (TRIC5) to band 1q23 by fluorescence in situ hybridization". Genomics. 22 (3): 634–6. doi:10.1006/geno.1994.1438. PMID 8001976.
  • Walkley NA, Demaine AG, Malik AN (Jan 1996). "Cloning, structure and mRNA expression of human Cctg, which encodes the chaperonin subunit CCT gamma". The Biochemical Journal. 313 (Pt 2): 381–9. doi:10.1042/bj3130381. PMC 1216920. PMID 8573069.
  • Feldman DE, Thulasiraman V, Ferreyra RG, Frydman J (Dec 1999). "Formation of the VHL-elongin BC tumor suppressor complex is mediated by the chaperonin TRiC". Molecular Cell. 4 (6): 1051–61. doi:10.1016/S1097-2765(00)80233-6. PMID 10635329.
  • Wong N, Chan A, Lee SW, Lam E, To KF, Lai PB, Li XN, Liew CT, Johnson PJ (Mar 2003). "Positional mapping for amplified DNA sequences on 1q21-q22 in hepatocellular carcinoma indicates candidate genes over-expression". Journal of Hepatology. 38 (3): 298–306. doi:10.1016/S0168-8278(02)00412-9. PMID 12586295.
  • Yuryev A, Wennogle LP (Feb 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics. 81 (2): 112–25. doi:10.1016/S0888-7543(02)00008-3. PMID 12620389.
  • Reuter TY, Medhurst AL, Waisfisz Q, Zhi Y, Herterich S, Hoehn H, Gross HJ, Joenje H, Hoatlin ME, Mathew CG, Huber PA (Oct 2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Experimental Cell Research. 289 (2): 211–21. doi:10.1016/S0014-4827(03)00261-1. PMID 14499622.
  • Imai Y, Soda M, Murakami T, Shoji M, Abe K, Takahashi R (Dec 2003). "A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death". The Journal of Biological Chemistry. 278 (51): 51901–10. doi:10.1074/jbc.M309655200. PMID 14532270.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.


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