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==Echocardiography/Ultrasound==
==Echocardiography/Ultrasound==
'''Focused Ultrasound Therapy:'''
'''Focused Ultrasound Therapy:''' <ref name="pmid28159329">{{cite journal| author=Miller DB, O'Callaghan JP| title=New horizons for focused ultrasound (FUS) - therapeutic applications in neurodegenerative diseases. | journal=Metabolism | year= 2017 | volume= 69S | issue=  | pages= S3-S7 | pmid=28159329 | doi=10.1016/j.metabol.2017.01.012 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28159329  }} </ref> <ref name="pmid27331236">{{cite journal| author=Galkin MV| title=[The use of transcranial focused ultrasound in CNS diseases]. | journal=Zh Vopr Neirokhir Im N N Burdenko | year= 2016 | volume= 80 | issue= 2 | pages= 108-118 | pmid=27331236 | doi=10.17116/neiro2016802108-118 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27331236  }} </ref> <ref name="pmid25420161">{{cite journal| author=Jolesz FA| title=Science to practice: opening the blood-brain barrier with focused ultrasound-a potential treatment for Alzheimer disease? | journal=Radiology | year= 2014 | volume= 273 | issue= 3 | pages= 631-3 | pmid=25420161 | doi=10.1148/radiol.14142033 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25420161  }} </ref> <ref name="pmid25107692">{{cite journal| author=Burgess A, Nhan T, Moffatt C, Klibanov AL, Hynynen K| title=Analysis of focused ultrasound-induced blood-brain barrier permeability in a mouse model of Alzheimer's disease using two-photon microscopy. | journal=J Control Release | year= 2014 | volume= 192 | issue=  | pages= 243-8 | pmid=25107692 | doi=10.1016/j.jconrel.2014.07.051 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25107692  }} </ref> <ref name="pmid25107692">{{cite journal| author=Burgess A, Nhan T, Moffatt C, Klibanov AL, Hynynen K| title=Analysis of focused ultrasound-induced blood-brain barrier permeability in a mouse model of Alzheimer's disease using two-photon microscopy. | journal=J Control Release | year= 2014 | volume= 192 | issue=  | pages= 243-8 | pmid=25107692 | doi=10.1016/j.jconrel.2014.07.051 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25107692  }} </ref>
*Non-invasive, therapeutic technology aiming to improve the quality of life with lower costs for patients with Alzheimer’s disease.
*Non-invasive, therapeutic technology aiming to improve the quality of life with lower costs for patients with Alzheimer’s disease.
*Beams of ultrasonic energy focus precisely and accurately on targets deep in the brain without damaging surrounding normal tissue.
*Beams of ultrasonic energy focus precisely and accurately on targets deep in the brain without damaging surrounding normal tissue.

Revision as of 06:27, 21 September 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

Focused ultrasound is a non-invasive, therapeutic technology aiming to improve the quality of life at lower costs for patients with Alzheimer’s disease.

Echocardiography/Ultrasound

Focused Ultrasound Therapy: [1] [2] [3] [4] [4]

  • Non-invasive, therapeutic technology aiming to improve the quality of life with lower costs for patients with Alzheimer’s disease.
  • Beams of ultrasonic energy focus precisely and accurately on targets deep in the brain without damaging surrounding normal tissue.
  • Ultrasound produces a variety of therapeutic effects eliminating the need for incisions or radiation at the focus where beams converge.
  • Preclinical studies have have shown promising results with the potential of focused ultrasound in enhancing the delivery of therapeutic drugs or antibodies to the brain.
  • Focused ultrasound in combination with microbubbles can safely open the blood-brain barrier (BBB) thereby enabling enhanced delivery of anti-amyloid antibodies to the brain. This method may reduce the number of plaques and improve cognition in Alzheimer’s disease subjects.

References

  1. Miller DB, O'Callaghan JP (2017). "New horizons for focused ultrasound (FUS) - therapeutic applications in neurodegenerative diseases". Metabolism. 69S: S3–S7. doi:10.1016/j.metabol.2017.01.012. PMID 28159329.
  2. Galkin MV (2016). "[The use of transcranial focused ultrasound in CNS diseases]". Zh Vopr Neirokhir Im N N Burdenko. 80 (2): 108–118. doi:10.17116/neiro2016802108-118. PMID 27331236.
  3. Jolesz FA (2014). "Science to practice: opening the blood-brain barrier with focused ultrasound-a potential treatment for Alzheimer disease?". Radiology. 273 (3): 631–3. doi:10.1148/radiol.14142033. PMID 25420161.
  4. 4.0 4.1 Burgess A, Nhan T, Moffatt C, Klibanov AL, Hynynen K (2014). "Analysis of focused ultrasound-induced blood-brain barrier permeability in a mouse model of Alzheimer's disease using two-photon microscopy". J Control Release. 192: 243–8. doi:10.1016/j.jconrel.2014.07.051. PMID 25107692.

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