HIV associated nephropathy causes: Difference between revisions

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==Overview==
==Overview==
Currently there are no known established causes of HIV-associated nephropathy. However, the genetic component, a key to the pathogenesis of the disease in blacks but not in other races is a factor that is seen in HIV-associated nephropathy.<ref name="pmid104693892">{{cite journal| author=Klotman PE| title=HIV-associated nephropathy. | journal=Kidney Int | year= 1999 | volume= 56 | issue= 3 | pages= 1161-76 | pmid=10469389 | doi=10.1046/j.1523-1755.1999.00748.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10469389  }}</ref>
==Causes==
==Causes==
Currently there are no known established causes of HIV-associated nephropathy. However, the genetic component, a key to the pathogenesis of the disease in blacks but not in other races is a factor that is seen in HIV-associated nephropathy. Another cause for HIV-associated nephropathy is the lack of a deletion mutation of CCR5 or CCR2, which is protective form HIV-1 infection.<ref name="pmid8756719">{{cite journal| author=Liu R, Paxton WA, Choe S, Ceradini D, Martin SR, Horuk R et al.| title=Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. | journal=Cell | year= 1996 | volume= 86 | issue= 3 | pages= 367-77 | pmid=8756719 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8756719  }}</ref>  
Currently there are no known established causes of HIV-associated nephropathy. However, the genetic component, a key to the pathogenesis of the disease in blacks but not in other races is a factor that is seen in HIV-associated nephropathy.<ref name="pmid104693893">{{cite journal| author=Klotman PE| title=HIV-associated nephropathy. | journal=Kidney Int | year= 1999 | volume= 56 | issue= 3 | pages= 1161-76 | pmid=10469389 | doi=10.1046/j.1523-1755.1999.00748.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10469389  }}</ref> Another cause for HIV-associated nephropathy is the lack of a deletion mutation of CCR5 or CCR2, which is protective form HIV-1 infection.<ref name="pmid8756719">{{cite journal| author=Liu R, Paxton WA, Choe S, Ceradini D, Martin SR, Horuk R et al.| title=Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. | journal=Cell | year= 1996 | volume= 86 | issue= 3 | pages= 367-77 | pmid=8756719 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8756719  }}</ref>  


Other factors that are attributed to the development of HIV-associated nephropathy is the use of intravenous drugs, however, this is inconclusive as patients with HIV-associated nephropathy are not all intravenous drug users.
Other factors that are attributed to the development of HIV-associated nephropathy is the use of intravenous drugs, however, this is inconclusive as patients with HIV-associated nephropathy are not all intravenous drug users.<ref name="pmid10469389">{{cite journal| author=Klotman PE| title=HIV-associated nephropathy. | journal=Kidney Int | year= 1999 | volume= 56 | issue= 3 | pages= 1161-76 | pmid=10469389 | doi=10.1046/j.1523-1755.1999.00748.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10469389  }}</ref>


==References==
==References==

Revision as of 16:22, 13 January 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2];Associate Editor(s)-in-Chief: Krzysztof Wierzbicki M.D. [3]

Overview

Currently there are no known established causes of HIV-associated nephropathy. However, the genetic component, a key to the pathogenesis of the disease in blacks but not in other races is a factor that is seen in HIV-associated nephropathy.[1]

Causes

Currently there are no known established causes of HIV-associated nephropathy. However, the genetic component, a key to the pathogenesis of the disease in blacks but not in other races is a factor that is seen in HIV-associated nephropathy.[2] Another cause for HIV-associated nephropathy is the lack of a deletion mutation of CCR5 or CCR2, which is protective form HIV-1 infection.[3]

Other factors that are attributed to the development of HIV-associated nephropathy is the use of intravenous drugs, however, this is inconclusive as patients with HIV-associated nephropathy are not all intravenous drug users.[4]

References

  1. Klotman PE (1999). "HIV-associated nephropathy". Kidney Int. 56 (3): 1161–76. doi:10.1046/j.1523-1755.1999.00748.x. PMID 10469389.
  2. Klotman PE (1999). "HIV-associated nephropathy". Kidney Int. 56 (3): 1161–76. doi:10.1046/j.1523-1755.1999.00748.x. PMID 10469389.
  3. Liu R, Paxton WA, Choe S, Ceradini D, Martin SR, Horuk R; et al. (1996). "Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection". Cell. 86 (3): 367–77. PMID 8756719.
  4. Klotman PE (1999). "HIV-associated nephropathy". Kidney Int. 56 (3): 1161–76. doi:10.1046/j.1523-1755.1999.00748.x. PMID 10469389.

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