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| __NOTOC__
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| {{Tenecteplase}} | | |valign=top| |
| {{CMG}}; {{AE}} {{SS}}
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| {{SB}} TNKASE<sup>®</sup>
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| ==Overview==
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| '''Tenecteplase (TNK)''' is an [[enzyme]] used as a [[thrombolytic drug]].
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| Tenecteplase is a [[tissue plasminogen activator]] (tPA) produced by recombinant DNA technology using an established mammalian cell line (Chinese hamster ovary cells). Tenecteplase is a 527 amino acid glycoprotein developed by introducing the following modifications to the complementary DNA (cDNA) for natural human tPA: a substitution of threonine 103 with asparagine, and a substitution of asparagine 117 with glutamine, both within the kringle 1 domain, and a tetra-alanine substitution at amino acids 296–299 in the protease domain.
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| Tenecteplase is a recombinant fibrin-specific plasminogen activator that is derived from native t-PA by modifications at three sites of the protein structure. It binds to the fibrin component of the thrombus (blood clot) and selectively converts thrombus-bound plasminogen to plasmin, which degrades the fibrin matrix of the thrombus. Tenecteplase has a higher fibrin specificity and greater resistance to inactivation by its endogenous inhibitor (PAI-1) compared to native t-PA.
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| ==Category==
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| Cardiovascular Drugs:Thrombolytic drugs
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| ==FDA Package Insert==
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| '''| [[Tenecteplase indications and usage|Indications and Usage]]'''
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| '''| [[Tenecteplase dosage and administration|Dosage and Administration]]'''
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| '''| [[Tenecteplase contraindications|Contraindications]]'''
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| '''| [[Tenecteplase warnings and precautions|Warnings and Precautions]]'''
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| '''| [[Tenecteplase adverse reactions|Adverse Reactions]]'''
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| '''| [[Tenecteplase drug interactions|Drug Interactions]]'''
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| '''| [[Tenecteplase use in specific populations|Use in Specific Populations]]'''
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| '''| [[Tenecteplase description|Description]]'''
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| '''| [[Tenecteplase clinical pharmacology|Clinical Pharmacology]]'''
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| '''| [[Tenecteplase nonclinical toxicology|Nonclinical Toxicology]]'''
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| '''| [[Tenecteplase clinical studies|Clinical Studies]]'''
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| '''| [[Tenecteplase how supplied storage and handling|How Supplied/Storage and Handling]]'''
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| '''| [[Tenecteplase labels and packages|Labels and Packages]]'''
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| ==Mechanism of Action==
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| ==References==
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| {{Reflist|2}}
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| {{Antithrombotics}}
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| [[Category:Thrombolytic drugs]]
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| [[Category:Cardiovascular Drugs]]
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| [[Category:Drugs]]
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| {{WikiDoc Help Menu}}
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| {{WikiDoc Sources}}
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