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{{WBRQuestion
{{WBRQuestion
|QuestionAuthor={{Ochuko}}
|QuestionAuthor={{Ochuko}} (Reviewed by {{YD}})
|ExamType=USMLE Step 1
|ExamType=USMLE Step 1
|MainCategory=Microbiology, Pathophysiology
|MainCategory=Microbiology, Pathophysiology
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|MainCategory=Microbiology, Pathophysiology
|MainCategory=Microbiology, Pathophysiology
|SubCategory=General Principles, Infectious Disease
|SubCategory=General Principles, Infectious Disease
|MainCategory=Microbiology, Pathophysiology
|MainCategory=Microbiology, Pathophysiology
|MainCategory=Microbiology, Pathophysiology
|MainCategory=Microbiology, Pathophysiology
|MainCategory=Microbiology, Pathophysiology
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|MainCategory=Microbiology, Pathophysiology
|MainCategory=Microbiology, Pathophysiology
|SubCategory=General Principles, Infectious Disease
|SubCategory=General Principles, Infectious Disease
|Prompt=A 28-year old female presents to the physicians office with complaints of fever, sore throat and swelling on the axilla. Physical examination revealed axillary lymphadenopathy with a temperature of 100F. A throat swab was taken and sent to the laboratory for culture. The organism cultured was a gram-positive rod that grew on tellurite agar, club shaped with metachromatic granules. The causative organism acts by which of the following mechanisms?
|Prompt=A 28-year-old woman presents to the physician's office with complaints of fever, sore throat, and swelling in her axilla. Her temperature is 38.3 °C (101 °F), her blood pressure is 136/86 mmHg, and her heart rate is 100/min. Physical examination is remarkable for axillary lymphadenopathy. A throat swab is performed and sent for culture. Two days later, a gram-positive club-shaped rod that contains metachromatic granules forms black colonies on tellurite agar. What is the mechanism of virulence that characterizes the organism responsible for this patient's condition?
|AnswerA=It binds to MHC II and T-cell receptor, resulting in polyclonal T-cell activation
|AnswerA=It binds to MHC II and T-cell receptor, resulting in polyclonal T-cell activation
|AnswerB=It acts via antibodies to M proteins to enhance the host defenses
|AnswerB=It acts via antibodies to M proteins to enhance the host defenses
|AnswerC=It inhibits protein synthesis via ADP ribosylation of EF-2
|AnswerC=It inhibits protein synthesis via ADP ribosylation of EF-2

Revision as of 21:35, 2 January 2015

 
Author [[PageAuthor::Ogheneochuko Ajari, MB.BS, MS [1] (Reviewed by Yazan Daaboul, M.D.)]]
Exam Type ExamType::USMLE Step 1
Main Category MainCategory::Microbiology, MainCategory::Pathophysiology
Sub Category SubCategory::General Principles, SubCategory::Infectious Disease
Prompt [[Prompt::A 28-year-old woman presents to the physician's office with complaints of fever, sore throat, and swelling in her axilla. Her temperature is 38.3 °C (101 °F), her blood pressure is 136/86 mmHg, and her heart rate is 100/min. Physical examination is remarkable for axillary lymphadenopathy. A throat swab is performed and sent for culture. Two days later, a gram-positive club-shaped rod that contains metachromatic granules forms black colonies on tellurite agar. What is the mechanism of virulence that characterizes the organism responsible for this patient's condition?]]
Answer A AnswerA::It binds to MHC II and T-cell receptor, resulting in polyclonal T-cell activation
Answer A Explanation AnswerAExp::
Answer B AnswerB::It acts via antibodies to M proteins to enhance the host defenses
Answer B Explanation AnswerBExp::
Answer C AnswerC::It inhibits protein synthesis via ADP ribosylation of EF-2
Answer C Explanation AnswerCExp::
Answer D AnswerD::It blocks GABA and glycine release from cells in the spinal cord
Answer D Explanation AnswerDExp::
Answer E AnswerE::It produces catalase to degrade hydrogen peroxide
Answer E Explanation AnswerEExp::
Right Answer RightAnswer::C
Explanation [[Explanation::

Educational Objective:
References: ]]

Approved Approved::Yes
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