View source for Twinrix

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==Overview==

'''Twinrix''' is a [[vaccine]] against [[hepatitis A]] and [[hepatitis B]].  Twinrix is administered over three doses.

The name was created because it is a mixture of two earlier vaccines - Havrix, an inactivated-virus [[Hepatitis A vaccine]], and [[ENGERIX-B]], a recombinant [[Hepatitis B vaccine]].

The [[Centers_for_Disease_Control_and_Prevention|CDC]] reports that clinical trials found the following levels of protection against Hep A and Hep B one month after each dose<ref>http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5037a4.htm</ref>:<br>
A: 93.8% 98.8% 99.9%<br>
B: 30.8% 78.2% 98.5%<br>

GlaxoSmithKline claims that its studies found 70% of subjects had antibodies against hepatitis B a month after just the first dose, however.<ref>http://emc.medicines.org.uk/emc/assets/c/html/displaydoc.asp?documentid=2061#PHARMACOLOGICAL_PROPS</ref> 

TWINRIX, HAVRIX and ENGERIX-B are registered [[trademark]]s of
[[GlaxoSmithKline]]; if the same vaccine is available from others, it will have another name.

==References==
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[[Category:Vaccines]]


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