View source for SH2D3A

{{Infobox_gene}}
'''SH2 domain-containing protein 3A''' is a [[protein]] that in humans is encoded by the ''SH2D3A'' [[gene]].<ref name="pmid10187783">{{cite journal | vauthors = Lu Y, Brush J, Stewart TA | title = NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway | journal = The Journal of Biological Chemistry | volume = 274 | issue = 15 | pages = 10047–52 | date = Apr 1999 | pmid = 10187783 | pmc =  | doi = 10.1074/jbc.274.15.10047 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SH2D3A SH2 domain containing 3A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10045| accessdate = }}</ref> The protein may be useful in [[Western Blot|Western Blots]] and [[ELISA|ELISAs]].<ref>{{cite web|title=Recombinant Human SH2D3A Protein|url=https://potassiun-channel.com/index.php/2017/08/01/Recombinant_Human_SH2D3A_Protein/|date=1 August 2017|website=potassium-channel|publisher=Potassium Channel|access-date=18 September 2017}}</ref>

== Interactions ==

SH2D3A has been shown to [[Protein-protein interaction|interact]] with the [[epidermal growth factor receptor]].<ref name=pmid10187783 /> The gene may play a role in [[c-Jun N-terminal kinases|JNK activation]].<ref>{{cite web|url=https://www.genecards.org/cgi-bin/carddisp.pl?gene=SH2D3A|title=SH2D3A Gene|publisher=Gene Cards|website=genecards.org|access-date=18 September 2017}}</ref>

== References ==
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== Further reading ==
{{refbegin | 2}}
* {{cite journal | vauthors = Near RI, Zhang Y, Makkinje A, Vanden Borre P, Lerner A | title = AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology | journal = Journal of Cellular Physiology | volume = 212 | issue = 3 | pages = 655–65 | date = Sep 2007 | pmid = 17427198 | pmc = 2640322 | doi = 10.1002/jcp.21059 }}
* {{cite journal | vauthors = Vervoort VS, Roselli S, Oshima RG, Pasquale EB | title = Splice variants and expression patterns of SHEP1, BCAR3 and NSP1, a gene family involved in integrin and receptor tyrosine kinase signaling | journal = Gene | volume = 391 | issue = 1-2 | pages = 161–70 | date = Apr 2007 | pmid = 17270363 | pmc = 1876674 | doi = 10.1016/j.gene.2006.12.016 }}
* {{cite journal | vauthors = Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H | title = Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer | journal = Molecular & Cellular Proteomics | volume = 4 | issue = 6 | pages = 785–95 | date = Jun 2005 | pmid = 15778465 | doi = 10.1074/mcp.M500021-MCP200 }}
* {{cite journal | vauthors = Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A | title = The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment | journal = Genome Research | volume = 13 | issue = 10 | pages = 2265–70 | date = Oct 2003 | pmid = 12975309 | pmc = 403697 | doi = 10.1101/gr.1293003 }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
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== External links ==
* {{UCSC genome browser|SH2D3A}}
* {{UCSC gene details|SH2D3A}}


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