View source for APPL1

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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_APPL1_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 2ela.
 | PDB = {{PDB2|2ela}}, {{PDB2|2elb}}
 | Name = Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
 | HGNCid = 24035
 | Symbol = APPL1
 | AltSymbols =; APPL; DIP13alpha
 | OMIM = 604299
 | ECnumber =  
 | Homologene = 32143
 | MGIid = 1920243
 | GeneAtlas_image1 = PBB_GE_APPL1_218158_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} 
 | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0010008 |text = endosome membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016581 |text = NuRD complex}} 
 | Process = {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 26060
    | Hs_Ensembl = ENSG00000157500
    | Hs_RefseqProtein = NP_036228
    | Hs_RefseqmRNA = NM_012096
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 57236894
    | Hs_GenLoc_end = 57282536
    | Hs_Uniprot = Q9UKG1
    | Mm_EntrezGene = 72993
    | Mm_Ensembl = ENSMUSG00000040760
    | Mm_RefseqmRNA = XM_975639
    | Mm_RefseqProtein = XP_980733
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 25745872
    | Mm_GenLoc_end = 25797435
    | Mm_Uniprot = Q8K3H0
  }}
}}
'''Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1''', also known as '''APPL1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26060| accessdate = }}</ref>

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.<ref name="entrez">{{cite web | title = Entrez Gene: APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26060| accessdate = }}</ref>
}}

==References==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi=  }}
*{{cite journal  | author=Mitsuuchi Y, Johnson SW, Sonoda G, ''et al.'' |title=Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2. |journal=Oncogene |volume=18 |issue= 35 |pages= 4891-8 |year= 1999 |pmid= 10490823 |doi= 10.1038/sj.onc.1203080 }}
*{{cite journal  | author=Nagase T, Kikuno R, Ishikawa KI, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 1 |pages= 65-73 |year= 2000 |pmid= 10718198 |doi=  }}
*{{cite journal  | author=Liu J, Yao F, Wu R, ''et al.'' |title=Mediation of the DCC apoptotic signal by DIP13 alpha. |journal=J. Biol. Chem. |volume=277 |issue= 29 |pages= 26281-5 |year= 2002 |pmid= 12011067 |doi= 10.1074/jbc.M204679200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Yang L, Lin HK, Altuwaijri S, ''et al.'' |title=APPL suppresses androgen receptor transactivation via potentiating Akt activity. |journal=J. Biol. Chem. |volume=278 |issue= 19 |pages= 16820-7 |year= 2003 |pmid= 12621049 |doi= 10.1074/jbc.M213163200 }}
*{{cite journal  | author=Miaczynska M, Christoforidis S, Giner A, ''et al.'' |title=APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment. |journal=Cell |volume=116 |issue= 3 |pages= 445-56 |year= 2004 |pmid= 15016378 |doi=  }}
*{{cite journal  | author=Nechamen CA, Thomas RM, Cohen BD, ''et al.'' |title=Human follicle-stimulating hormone (FSH) receptor interacts with the adaptor protein APPL1 in HEK 293 cells: potential involvement of the PI3K pathway in FSH signaling. |journal=Biol. Reprod. |volume=71 |issue= 2 |pages= 629-36 |year= 2005 |pmid= 15070827 |doi= 10.1095/biolreprod.103.025833 }}
*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal  | author=Ballif BA, Villén J, Beausoleil SA, ''et al.'' |title=Phosphoproteomic analysis of the developing mouse brain. |journal=Mol. Cell Proteomics |volume=3 |issue= 11 |pages= 1093-101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Mao X, Kikani CK, Riojas RA, ''et al.'' |title=APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function. |journal=Nat. Cell Biol. |volume=8 |issue= 5 |pages= 516-23 |year= 2006 |pmid= 16622416 |doi= 10.1038/ncb1404 }}
*{{cite journal  | author=Nechamen CA, Thomas RM, Dias JA |title=APPL1, APPL2, Akt2 and FOXO1a interact with FSHR in a potential signaling complex. |journal=Mol. Cell. Endocrinol. |volume=260-262 |issue=  |pages= 93-9 |year= 2007 |pmid= 17030088 |doi= 10.1016/j.mce.2006.08.014 }}
*{{cite journal  | author=Cheng KK, Lam KS, Wang Y, ''et al.'' |title=Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by APPL1 in endothelial cells. |journal=Diabetes |volume=56 |issue= 5 |pages= 1387-94 |year= 2007 |pmid= 17287464 |doi= 10.2337/db06-1580 }}
*{{cite journal  | author=Li J, Mao X, Dong LQ, ''et al.'' |title=Crystal structures of the BAR-PH and PTB domains of human APPL1. |journal=Structure |volume=15 |issue= 5 |pages= 525-33 |year= 2007 |pmid= 17502098 |doi= 10.1016/j.str.2007.03.011 }}
*{{cite journal  | author=Zhu G, Chen J, Liu J, ''et al.'' |title=Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5. |journal=EMBO J. |volume=26 |issue= 14 |pages= 3484-93 |year= 2007 |pmid= 17581628 |doi= 10.1038/sj.emboj.7601771 }}
*{{cite journal  | author=Saito T, Jones CC, Huang S, ''et al.'' |title=The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation. |journal=J. Biol. Chem. |volume=282 |issue= 44 |pages= 32280-7 |year= 2007 |pmid= 17848569 |doi= 10.1074/jbc.M704150200 }}
}}
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