Transcription Factor II D
|TATA box binding protein|
|Alt. symbols||TFIID, GTF2D1, SCA17|
|Locus||Chr. 6 q27|
Transcription Factor II D (TFIID) is one of several basal transcription factors, all which are involved in the assembly of the basal apparatus of RNA polymerase II. TFIID is itself composed of several subunits called TAFs (of which there are 14) and the TATA Binding Protein (TBP) of which only the TBP is necessary for a basal-level of transcription.
The TAFs of TFIID are necessary to increase the rate of transcription but can only do so when bound by activators. Some TAFs may provide sites that interact with different activators whilst some activators may interact with more than one TAF.
It is believed that activators assist in the binding of TFIID to the TATA box and/or binding of other transcriptional activators around the TFIID-TATA box complex, thereby increasing the rate of initiation
- Lewin, Benjamin (2004). Genes VIII. Upper Saddle River, NJ: Pearson Prentice Hall. pp. p636–637. ISBN 0-13-144946-X.
- Kao CC, Lieberman PM, Schmidt MC, Zhou Q, Pei R, Berk AJ (1990). "Cloning of a transcriptionally active human TATA binding factor". Science. 248 (4963): 1646–50. doi:10.1126/science.2194289. PMID 2194289.
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