Spindle apparatus

(Redirected from Spindle fiber)
Jump to: navigation, search
Micrograph showing condensed chromosomes in blue and the mitotic spindle in green during prometaphase of mitosis

WikiDoc Resources for Spindle apparatus

Articles

Most recent articles on Spindle apparatus

Most cited articles on Spindle apparatus

Review articles on Spindle apparatus

Articles on Spindle apparatus in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Spindle apparatus

Images of Spindle apparatus

Photos of Spindle apparatus

Podcasts & MP3s on Spindle apparatus

Videos on Spindle apparatus

Evidence Based Medicine

Cochrane Collaboration on Spindle apparatus

Bandolier on Spindle apparatus

TRIP on Spindle apparatus

Clinical Trials

Ongoing Trials on Spindle apparatus at Clinical Trials.gov

Trial results on Spindle apparatus

Clinical Trials on Spindle apparatus at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Spindle apparatus

NICE Guidance on Spindle apparatus

NHS PRODIGY Guidance

FDA on Spindle apparatus

CDC on Spindle apparatus

Books

Books on Spindle apparatus

News

Spindle apparatus in the news

Be alerted to news on Spindle apparatus

News trends on Spindle apparatus

Commentary

Blogs on Spindle apparatus

Definitions

Definitions of Spindle apparatus

Patient Resources / Community

Patient resources on Spindle apparatus

Discussion groups on Spindle apparatus

Patient Handouts on Spindle apparatus

Directions to Hospitals Treating Spindle apparatus

Risk calculators and risk factors for Spindle apparatus

Healthcare Provider Resources

Symptoms of Spindle apparatus

Causes & Risk Factors for Spindle apparatus

Diagnostic studies for Spindle apparatus

Treatment of Spindle apparatus

Continuing Medical Education (CME)

CME Programs on Spindle apparatus

International

Spindle apparatus en Espanol

Spindle apparatus en Francais

Business

Spindle apparatus in the Marketplace

Patents on Spindle apparatus

Experimental / Informatics

List of terms related to Spindle apparatus


Overview

During cell division, the spindle apparatus pulls together the chromosomes into the two daughter cells.

The spindle apparatus is a structure of the eukaryotic cytoskeleton involved in mitosis and meiosis, often referred to as the mitotic spindle during mitosis and the meiotic spindle during meiosis. Its function is to segregate chromosomes during cell division (either mitosis or meiosis) to the daughter cells. It consists of a bundle of microtubules joined at the ends but spread out in the middle, vaguely ellipsoid in shape. In the wide middle portion, known as the spindle midzone, antiparallel microtubules are bundled by kinesins. At the pointed ends, known as spindle poles, microtubules are nucleated by the centrosomes in the cells of most animals.

During spindle assembly in prometaphase, some of the spindle's microtubules attach to the kinetochores that assemble on the centromere portion of the chromosomes. The chromosomes are pulled into alignment along the spindle midzone to form the metaphase spindle. Once all the chromosomes are aligned with sister chromatids pointing to opposite ends of the spindle, the cell enters anaphase, in which the chromatids separate and move toward their respective poles. Since the center of the spindle specifies the plane along which the cell will divide during cytokinesis, this ensures that each daughter cell will receive one of each chromatid. The mitotic kinase aurora A is required for proper spindle assembly and separation.

According to a recent publication[1], lamin B is a key component of the spindle matrix helping microtubule assembly. The mitotic spindle will not form without it.

References

  1. M. Y. Tsai, S. Wang, J. M. Heidinger, D. K. Shumaker, S. A. Adam, R. D. Goldman & Y. Zheng (2006-03-31). "A mitotic lamin B matrix induced by RanGTP required for spindle assembly". Science. 311 (5769): 1887–1193. doi:10.1126/science.1122771. 




Linked-in.jpg