Pyruvate, phosphate dikinase

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In enzymology, a pyruvate, phosphate dikinase (EC is an enzyme that catalyzes the chemical reaction

ATP + pyruvate + phosphate AMP + phosphoenolpyruvate + diphosphate

The 3 substrates of this enzyme are ATP, pyruvate, and phosphate, whereas its 3 products are AMP, phosphoenolpyruvate, and diphosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with paired acceptors. The systematic name of this enzyme class is ATP:pyruvate, phosphate phosphotransferase. Other names in common use include pyruvate, orthophosphate dikinase, pyruvate-phosphate dikinase (phosphorylating), pyruvate, phosphate dikinase, pyruvate-inorganic phosphate dikinase, pyruvate-phosphate dikinase, pyruvate-phosphate ligase, pyruvic-phosphate dikinase, pyruvic-phosphate ligase, pyruvate, Pi dikinase, and PPDK. This enzyme participates in pyruvate metabolism and carbon fixation.

Structural studies

As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes 1DIK, 1GGO, 1H6Z, 1JDE, 1KBL, 1KC7, 1VBG, 1VBH, 2DIK, and 2FM4.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Hatch MD, Slack CR (1968). "A new enzyme for the interconversion of pyruvate and phosphopyruvate and its role in the C4 dicarboxylic acid pathway of photosynthesis". Biochem. J. 106: 141&ndash, 6. PMID 4305612.
  • Reeves RE (1968). "A new enzyme with the glycolytic function of pyruvate kinase". J. Biol. Chem. 243: 3202&ndash, 4. PMID 4297474.
  • Reeves RE (1971). "Pyruvate,phosphate dikinase from Bacteroides symbiosus". Biochem. J. 125: 531&ndash, 9. PMID 5144757.
  • Reeves RE, Menzies RA, Hsu DS (1968). "The pyruvate-phosphate dikinase reaction. The fate of phosphate and the equilibrium". J. Biol. Chem. 243: 5486&ndash, 91. PMID 4302788.

External links

The CAS registry number for this enzyme class is 9027-40-1.

Gene Ontology (GO) codes