FUS

Fusion (involved in t(12;16) in malignant liposarcoma)
Identifiers
Symbols	FUS ; CHOP; FUS-CHOP; FUS1; TLS; TLS/CHOP
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3639
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Fusion (involved in t(12;16) in malignant liposarcoma), also known as FUS, is a human gene.

Further reading

• Kaplowitz N, Ji C (2007). "Unfolding new mechanisms of alcoholic liver disease in the endoplasmic reticulum". J. Gastroenterol. Hepatol. 21 Suppl 3: S7–9. doi:10.1111/j.1440-1746.2006.04581.x. PMID 16958678.
• Eneroth M, Mandahl N, Heim S; et al. (1990). "Localization of the chromosomal breakpoints of the t(12;16) in liposarcoma to subbands 12q13.3 and 16p11.2". Cancer Genet. Cytogenet. 48 (1): 101–7. PMID 2372777.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rabbitts TH, Forster A, Larson R, Nathan P (1993). "Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma". Nat. Genet. 4 (2): 175–80. doi:10.1038/ng0693-175. PMID 7503811.CS1 maint: Multiple names: authors list (link)
• Panagopoulos I, Mandahl N, Ron D; et al. (1995). "Characterization of the CHOP breakpoints and fusion transcripts in myxoid liposarcomas with the 12;16 translocation". Cancer Res. 54 (24): 6500–3. PMID 7987849.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ichikawa H, Shimizu K, Hayashi Y, Ohki M (1994). "An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation". Cancer Res. 54 (11): 2865–8. PMID 8187069.CS1 maint: Multiple names: authors list (link)
• Crozat A, Aman P, Mandahl N, Ron D (1993). "Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma". Nature. 363 (6430): 640–4. doi:10.1038/363640a0. PMID 8510758.CS1 maint: Multiple names: authors list (link)
• Aman P, Panagopoulos I, Lassen C; et al. (1997). "Expression patterns of the human sarcoma-associated genes FUS and EWS and the genomic structure of FUS". Genomics. 37 (1): 1–8. doi:10.1006/geno.1996.0513. PMID 8921363.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zinszner H, Sok J, Immanuel D; et al. (1997). "TLS (FUS) binds RNA in vivo and engages in nucleo-cytoplasmic shuttling". J. Cell. Sci. 110 ( Pt 15): 1741–50. PMID 9264461.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Powers CA, Mathur M, Raaka BM; et al. (1998). "TLS (translocated-in-liposarcoma) is a high-affinity interactor for steroid, thyroid hormone, and retinoid receptors". Mol. Endocrinol. 12 (1): 4–18. PMID 9440806.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hallier M, Lerga A, Barnache S; et al. (1998). "The transcription factor Spi-1/PU.1 interacts with the potential splicing factor TLS". J. Biol. Chem. 273 (9): 4838–42. PMID 9478924.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang D, Paley AJ, Childs G (1998). "The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription". J. Biol. Chem. 273 (29): 18086–91. PMID 9660765.CS1 maint: Multiple names: authors list (link)
• Yang L, Embree LJ, Tsai S, Hickstein DD (1998). "Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing". J. Biol. Chem. 273 (43): 27761–4. PMID 9774382.CS1 maint: Multiple names: authors list (link)
• Morohoshi F, Ootsuka Y, Arai K; et al. (1998). "Genomic structure of the human RBP56/hTAFII68 and FUS/TLS genes". Gene. 221 (2): 191–8. PMID 9795213.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bertrand P, Akhmedov AT, Delacote F; et al. (1999). "Human POMp75 is identified as the pro-oncoprotein TLS/FUS: both POMp75 and POMp100 DNA homologous pairing activities are associated to cell proliferation". Oncogene. 18 (31): 4515–21. doi:10.1038/sj.onc.1203048. PMID 10442642.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Baechtold H, Kuroda M, Sok J; et al. (1999). "Human 75-kDa DNA-pairing protein is identical to the pro-oncoprotein TLS/FUS and is able to promote D-loop formation". J. Biol. Chem. 274 (48): 34337–42. PMID 10567410.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang L, Embree LJ, Hickstein DD (2000). "TLS-ERG leukemia fusion protein inhibits RNA splicing mediated by serine-arginine proteins". Mol. Cell. Biol. 20 (10): 3345–54. PMID 10779324.CS1 maint: Multiple names: authors list (link)
• Husi H, Ward MA, Choudhary JS; et al. (2000). "Proteomic analysis of NMDA receptor-adhesion protein signaling complexes". Nat. Neurosci. 3 (7): 661–9. doi:10.1038/76615. PMID 10862698.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Uranishi H, Tetsuka T, Yamashita M; et al. (2001). "Involvement of the pro-oncoprotein TLS (translocated in liposarcoma) in nuclear factor-kappa B p65-mediated transcription as a coactivator". J. Biol. Chem. 276 (16): 13395–401. doi:10.1074/jbc.M011176200. PMID 11278855.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Saunders LR, Perkins DJ, Balachandran S; et al. (2001). "Characterization of two evolutionarily conserved, alternatively spliced nuclear phosphoproteins, NFAR-1 and -2, that function in mRNA processing and interact with the double-stranded RNA-dependent protein kinase, PKR". J. Biol. Chem. 276 (34): 32300–12. doi:10.1074/jbc.M104207200. PMID 11438536.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lee J, Bedford MT (2002). "PABP1 identified as an arginine methyltransferase substrate using high-density protein arrays". EMBO Rep. 3 (3): 268–73. doi:10.1093/embo-reports/kvf052. PMID 11850402.