Mesuximide

Mesuximide

Clinical data
AHFS/Drugs.com	Consumer Drug Information
MedlinePlus	a682028
Pregnancy category	US: C (Risk not ruled out)
Routes of administration	Oral
ATC code	N03AD03 (WHO)
Legal status
Legal status	US: ℞-only
Pharmacokinetic data
Metabolism	Hepatic (demethylation and glucuronidation)
Elimination half-life	1.4–2.6 hours (mesuximide) 28–38 hours (active metabolite)
Excretion	Renal
Identifiers
IUPAC name (RS)-1,3-dimethyl-3-phenyl-pyrrolidine-2,5-dione
CAS Number	77-41-8 Y
PubChem CID	6476
DrugBank	DB05246 N
ChemSpider	6231 Y
UNII	0G76K8X6C0
KEGG	D00404 Y
ChEMBL	ChEMBL697 Y
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C12H13NO2
Molar mass	203.237 g/mol
3D model (JSmol)	Interactive image
SMILES O=C2N(C(=O)CC2(c1ccccc1)C)C
InChI InChI=1S/C12H13NO2/c1-12(9-6-4-3-5-7-9)8-10(14)13(2)11(12)15/h3-7H,8H2,1-2H3 Y Key:AJXPJJZHWIXJCJ-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

WikiDoc Resources for Mesuximide
Articles
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Evidence Based Medicine
Cochrane Collaboration on Mesuximide Bandolier on Mesuximide TRIP on Mesuximide
Clinical Trials
Ongoing Trials on Mesuximide at Clinical Trials.gov Trial results on Mesuximide Clinical Trials on Mesuximide at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Mesuximide NICE Guidance on Mesuximide NHS PRODIGY Guidance FDA on Mesuximide CDC on Mesuximide
Books
Books on Mesuximide
News
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Commentary
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Definitions
Definitions of Mesuximide
Patient Resources / Community
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Healthcare Provider Resources
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Continuing Medical Education (CME)
CME Programs on Mesuximide
International
Mesuximide en Espanol Mesuximide en Francais
Business
Mesuximide in the Marketplace Patents on Mesuximide
Experimental / Informatics
List of terms related to Mesuximide

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Mesuximide (or methsuximide, methosuximide) is a succinimide anticonvulsant medication. It is sold as a racemate by Pfizer under the tradenames Petinutin (Switzerland) and Celontin (United States). The therapeutic efficacy of methosuximide is largely due to its pharmacologically active metabolite, N-desmethylmethosuximide, which has a longer half-life and attains much higher plasma levels than its parent.