Cylindromatosis

Cylindromatosis (turban tumor syndrome)
PDB rendering based on 1ixd.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1ixd​, 1whl​, 1whm​
Identifiers
Symbols	CYLD ; CDMT; CYLD1; CYLDI; EAC; FLJ20180; FLJ31664; HSPC057; KIAA0849; USPL2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 9069
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Cylindromatosis (turban tumor syndrome), also known as CYLD, is a human gene.

This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Further reading

• Nakajima D, Okazaki N, Yamakawa H; et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. PMID 12168954.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lian F, Cockerell CJ (2006). "Cutaneous appendage tumors: familial cylindromatosis and associated tumors update". Advances in dermatology. 21: 217–34. PMID 16350444.
• Biggs PJ, Wooster R, Ford D; et al. (1996). "Familial cylindromatosis (turban tumour syndrome) gene localised to chromosome 16q12-q13: evidence for its role as a tumour suppressor gene". Nat. Genet. 11 (4): 441–3. doi:10.1038/ng1295-441. PMID 7493027.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Biggs PJ, Chapman P, Lakhani SR; et al. (1996). "The cylindromatosis gene (cyld1) on chromosome 16q may be the only tumour suppressor gene involved in the development of cylindromas". Oncogene. 12 (6): 1375–7. PMID 8649842.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagase T, Ishikawa K, Suyama M; et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. PMID 10048485.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Thomson SA, Rasmussen SA, Zhang J, Wallace MR (1999). "A new hereditary cylindromatosis family associated with CYLD1 on chromosome 16". Hum. Genet. 105 (1–2): 171–3. PMID 10480375.CS1 maint: Multiple names: authors list (link)
• Bignell GR, Warren W, Seal S; et al. (2000). "Identification of the familial cylindromatosis tumour-suppressor gene". Nat. Genet. 25 (2): 160–5. doi:10.1038/76006. PMID 10835629.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang QH, Ye M, Wu XY; et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. PMID 11042152.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Trompouki E, Hatzivassiliou E, Tsichritzis T; et al. (2003). "CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members". Nature. 424 (6950): 793–6. doi:10.1038/nature01803. PMID 12917689.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brummelkamp TR, Nijman SM, Dirac AM, Bernards R (2003). "Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB". Nature. 424 (6950): 797–801. doi:10.1038/nature01811. PMID 12917690.CS1 maint: Multiple names: authors list (link)
• Kovalenko A, Chable-Bessia C, Cantarella G; et al. (2003). "The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination". Nature. 424 (6950): 801–5. doi:10.1038/nature01802. PMID 12917691.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hu G, Onder M, Gill M; et al. (2003). "A novel missense mutation in CYLD in a family with Brooke-Spiegler syndrome". J. Invest. Dermatol. 121 (4): 732–4. doi:10.1046/j.1523-1747.2003.12514.x. PMID 14632188.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Regamey A, Hohl D, Liu JW; et al. (2004). "The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor kappaB activation by tumor necrosis factor". J. Exp. Med. 198 (12): 1959–64. doi:10.1084/jem.20031187. PMID 14676304.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang XJ, Liang YH, He PP; et al. (2004). "Identification of the cylindromatosis tumor-suppressor gene responsible for multiple familial trichoepithelioma". J. Invest. Dermatol. 122 (3): 658–64. doi:10.1111/j.0022-202X.2004.22321.x. PMID 15086550.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jono H, Lim JH, Chen LF; et al. (2004). "NF-kappaB is essential for induction of CYLD, the negative regulator of NF-kappaB: evidence for a novel inducible autoregulatory feedback pathway". J. Biol. Chem. 279 (35): 36171–4. doi:10.1074/jbc.M406638200. PMID 15226292.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)