XYLT1: Difference between revisions

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{{Infobox_gene}}
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'''Xylosyltransferase 1''' is an [[enzyme]] that in humans is encoded by the ''XYLT1'' [[gene]].<ref name="pmid11099377">{{cite journal | vauthors = Gotting C, Kuhn J, Zahn R, Brinkmann T, Kleesiek K | title = Molecular cloning and expression of human UDP-d-Xylose:proteoglycan core protein beta-d-xylosyltransferase and its first isoform XT-II | journal = J Mol Biol | volume = 304 | issue = 4 | pages = 517–28 |date=Jan 2001 | pmid = 11099377 | pmc =  | doi = 10.1006/jmbi.2000.4261 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: XYLT1 xylosyltransferase I| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64131| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Xylosyltransferase I
| HGNCid = 15516
| Symbol = XYLT1
| AltSymbols =; XT-I; XT1
| OMIM = 608124
| ECnumber = 
| Homologene = 32534
| MGIid = 2451073
| Function = {{GNF_GO|id=GO:0008375 |text = acetylglucosaminyltransferase activity}} {{GNF_GO|id=GO:0016757 |text = transferase activity, transferring glycosyl groups}} {{GNF_GO|id=GO:0030158 |text = protein xylosyltransferase activity}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
  | Process = {{GNF_GO|id=GO:0006024 |text = glycosaminoglycan biosynthetic process}}  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 64131
    | Hs_Ensembl = 
    | Hs_RefseqProtein = XP_001125986
    | Hs_RefseqmRNA = XM_001125986
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 233781
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_175645
    | Mm_RefseqProtein = NP_783576
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Xylosyltransferase I''', also known as '''XYLT1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: XYLT1 xylosyltransferase I| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64131| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Xylosyltransferase (XT; EC 2.4.2.26) catalyzes the transfer of UDP-xylose to serine residues within XT recognition sequences of target proteins. Addition of this xylose to the core protein is required for the biosynthesis of the glycosaminoglycan chains characteristic of proteoglycans.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: XYLT1 xylosyltransferase I| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64131| accessdate = }}</ref>
| summary_text = Xylosyltransferase (XT; EC 2.4.2.26) [[Catalyst|catalyzes]] the transfer of UDP-xylose to [[serine]] residues within XT recognition sequences of target proteins. Addition of this [[xylose]] to the core protein is required for the biosynthesis of the [[glycosaminoglycan]] chains characteristic of [[proteoglycan]]s.[supplied by OMIM]<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Götting C, Sollberg S, Kuhn J, ''et al.'' |title=Serum xylosyltransferase: a new biochemical marker of the sclerotic process in systemic sclerosis. |journal=J. Invest. Dermatol. |volume=112 |issue= 6 |pages= 919-24 |year= 1999 |pmid= 10383739 |doi= 10.1046/j.1523-1747.1999.00590.x }}
*{{cite journal   |vauthors=Götting C, Sollberg S, Kuhn J, etal |title=Serum xylosyltransferase: a new biochemical marker of the sclerotic process in systemic sclerosis. |journal=J. Invest. Dermatol. |volume=112 |issue= 6 |pages= 919–24 |year= 1999 |pmid= 10383739 |doi= 10.1046/j.1523-1747.1999.00590.x }}
*{{cite journal | author=Kuhn J, Götting C, Schnölzer M, ''et al.'' |title=First isolation of human UDP-D-xylose: proteoglycan core protein beta-D-xylosyltransferase secreted from cultured JAR choriocarcinoma cells. |journal=J. Biol. Chem. |volume=276 |issue= 7 |pages= 4940-7 |year= 2001 |pmid= 11087729 |doi= 10.1074/jbc.M005111200 }}
*{{cite journal   |vauthors=Kuhn J, Götting C, Schnölzer M, etal |title=First isolation of human UDP-D-xylose: proteoglycan core protein beta-D-xylosyltransferase secreted from cultured JAR choriocarcinoma cells. |journal=J. Biol. Chem. |volume=276 |issue= 7 |pages= 4940–7 |year= 2001 |pmid= 11087729 |doi= 10.1074/jbc.M005111200 }}
*{{cite journal  | author=Götting C, Kuhn J, Zahn R, ''et al.'' |title=Molecular cloning and expression of human UDP-d-Xylose:proteoglycan core protein beta-d-xylosyltransferase and its first isoform XT-II. |journal=J. Mol. Biol. |volume=304 |issue= 4 |pages= 517-28 |year= 2001 |pmid= 11099377 |doi= 10.1006/jmbi.2000.4261 }}
*{{cite journal  | vauthors=Götting C, Kuhn J, Brinkmann T, Kleesiek K |title=Xylosyltransferase activity in seminal plasma of infertile men. |journal=Clin. Chim. Acta |volume=317 |issue= 1-2 |pages= 199–202 |year= 2002 |pmid= 11814476 |doi=10.1016/S0009-8981(01)00793-8 }}
*{{cite journal  | author=Götting C, Kuhn J, Brinkmann T, Kleesiek K |title=Xylosyltransferase activity in seminal plasma of infertile men. |journal=Clin. Chim. Acta |volume=317 |issue= 1-2 |pages= 199-202 |year= 2002 |pmid= 11814476 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Götting C, Müller S, Schöttler M, etal |title=Analysis of the DXD motifs in human xylosyltransferase I required for enzyme activity. |journal=J. Biol. Chem. |volume=279 |issue= 41 |pages= 42566–73 |year= 2004 |pmid= 15294915 |doi= 10.1074/jbc.M401340200 }}
*{{cite journal | author=Götting C, Müller S, Schöttler M, ''et al.'' |title=Analysis of the DXD motifs in human xylosyltransferase I required for enzyme activity. |journal=J. Biol. Chem. |volume=279 |issue= 41 |pages= 42566-73 |year= 2004 |pmid= 15294915 |doi= 10.1074/jbc.M401340200 }}
*{{cite journal   |vauthors=Müller S, Schöttler M, Schön S, etal |title=Human xylosyltransferase I: functional and biochemical characterization of cysteine residues required for enzymic activity. |journal=Biochem. J. |volume=386 |issue= Pt 2 |pages= 227–36 |year= 2005 |pmid= 15461586 |doi= 10.1042/BJ20041206 | pmc=1134786 }}
*{{cite journal | author=Müller S, Schöttler M, Schön S, ''et al.'' |title=Human xylosyltransferase I: functional and biochemical characterization of cysteine residues required for enzymic activity. |journal=Biochem. J. |volume=386 |issue= Pt 2 |pages= 227-36 |year= 2005 |pmid= 15461586 |doi= 10.1042/BJ20041206 }}
*{{cite journal   |vauthors=Götting C, Hendig D, Adam A, etal |title=Elevated xylosyltransferase I activities in pseudoxanthoma elasticum (PXE) patients as a marker of stimulated proteoglycan biosynthesis. |journal=J. Mol. Med. |volume=83 |issue= 12 |pages= 984–92 |year= 2006 |pmid= 16133423 |doi= 10.1007/s00109-005-0693-x }}
*{{cite journal | author=Götting C, Hendig D, Adam A, ''et al.'' |title=Elevated xylosyltransferase I activities in pseudoxanthoma elasticum (PXE) patients as a marker of stimulated proteoglycan biosynthesis. |journal=J. Mol. Med. |volume=83 |issue= 12 |pages= 984-92 |year= 2006 |pmid= 16133423 |doi= 10.1007/s00109-005-0693-x }}
*{{cite journal   |vauthors=Schön S, Prante C, Müller S, etal |title=Impact of polymorphisms in the genes encoding xylosyltransferase I and a homologue in type 1 diabetic patients with and without nephropathy. |journal=Kidney Int. |volume=68 |issue= 4 |pages= 1483–90 |year= 2005 |pmid= 16164625 |doi= 10.1111/j.1523-1755.2005.00561.x }}
*{{cite journal | author=Schön S, Prante C, Müller S, ''et al.'' |title=Impact of polymorphisms in the genes encoding xylosyltransferase I and a homologue in type 1 diabetic patients with and without nephropathy. |journal=Kidney Int. |volume=68 |issue= 4 |pages= 1483-90 |year= 2005 |pmid= 16164625 |doi= 10.1111/j.1523-1755.2005.00561.x }}
*{{cite journal   |vauthors=Müller S, Disse J, Schöttler M, etal |title=Human xylosyltransferase I and N-terminal truncated forms: functional characterization of the core enzyme. |journal=Biochem. J. |volume=394 |issue= Pt 1 |pages= 163–71 |year= 2006 |pmid= 16225459 |doi= 10.1042/BJ20051606 | pmc=1386014 }}
*{{cite journal | author=Müller S, Disse J, Schöttler M, ''et al.'' |title=Human xylosyltransferase I and N-terminal truncated forms: functional characterization of the core enzyme. |journal=Biochem. J. |volume=394 |issue= Pt 1 |pages= 163-71 |year= 2006 |pmid= 16225459 |doi= 10.1042/BJ20051606 }}
*{{cite journal   |vauthors=Schön S, Prante C, Bahr C, etal |title=Cloning and recombinant expression of active full-length xylosyltransferase I (XT-I) and characterization of subcellular localization of XT-I and XT-II. |journal=J. Biol. Chem. |volume=281 |issue= 20 |pages= 14224–31 |year= 2006 |pmid= 16569644 |doi= 10.1074/jbc.M510690200 }}
*{{cite journal | author=Schön S, Prante C, Bahr C, ''et al.'' |title=Cloning and recombinant expression of active full-length xylosyltransferase I (XT-I) and characterization of subcellular localization of XT-I and XT-II. |journal=J. Biol. Chem. |volume=281 |issue= 20 |pages= 14224-31 |year= 2006 |pmid= 16569644 |doi= 10.1074/jbc.M510690200 }}
*{{cite journal   |vauthors=Schön S, Schulz V, Prante C, etal |title=Polymorphisms in the xylosyltransferase genes cause higher serum XT-I activity in patients with pseudoxanthoma elasticum (PXE) and are involved in a severe disease course. |journal=J. Med. Genet. |volume=43 |issue= 9 |pages= 745–9 |year= 2007 |pmid= 16571645 |doi= 10.1136/jmg.2006.040972 | pmc=2593031 }}
*{{cite journal | author=Schön S, Schulz V, Prante C, ''et al.'' |title=Polymorphisms in the xylosyltransferase genes cause higher serum XT-I activity in patients with pseudoxanthoma elasticum (PXE) and are involved in a severe disease course. |journal=J. Med. Genet. |volume=43 |issue= 9 |pages= 745-9 |year= 2007 |pmid= 16571645 |doi= 10.1136/jmg.2006.040972 }}
*{{cite journal   |vauthors=Prante C, Bieback K, Funke C, etal |title=The formation of extracellular matrix during chondrogenic differentiation of mesenchymal stem cells correlates with increased levels of xylosyltransferase I. |journal=Stem Cells |volume=24 |issue= 10 |pages= 2252–61 |year= 2006 |pmid= 16778156 |doi= 10.1634/stemcells.2005-0508 }}
*{{cite journal | author=Prante C, Bieback K, Funke C, ''et al.'' |title=The formation of extracellular matrix during chondrogenic differentiation of mesenchymal stem cells correlates with increased levels of xylosyltransferase I. |journal=Stem Cells |volume=24 |issue= 10 |pages= 2252-61 |year= 2006 |pmid= 16778156 |doi= 10.1634/stemcells.2005-0508 }}
*{{cite journal   |vauthors=Schön S, Prante C, Bahr C, etal |title=The xylosyltransferase I gene polymorphism c.343G>T (p.A125S) is a risk factor for diabetic nephropathy in type 1 diabetes. |journal=Diabetes Care |volume=29 |issue= 10 |pages= 2295–9 |year= 2007 |pmid= 17003309 |doi= 10.2337/dc06-0344 }}
*{{cite journal | author=Schön S, Prante C, Bahr C, ''et al.'' |title=The xylosyltransferase I gene polymorphism c.343G>T (p.A125S) is a risk factor for diabetic nephropathy in type 1 diabetes. |journal=Diabetes Care |volume=29 |issue= 10 |pages= 2295-9 |year= 2007 |pmid= 17003309 |doi= 10.2337/dc06-0344 }}
*{{cite journal  | vauthors=Cuellar K, Chuong H, Hubbell SM, Hinsdale ME |title=Biosynthesis of chondroitin and heparan sulfate in chinese hamster ovary cells depends on xylosyltransferase II. |journal=J. Biol. Chem. |volume=282 |issue= 8 |pages= 5195–200 |year= 2007 |pmid= 17189266 |doi= 10.1074/jbc.M611048200 }}
*{{cite journal  | author=Cuellar K, Chuong H, Hubbell SM, Hinsdale ME |title=Biosynthesis of chondroitin and heparan sulfate in chinese hamster ovary cells depends on xylosyltransferase II. |journal=J. Biol. Chem. |volume=282 |issue= 8 |pages= 5195-200 |year= 2007 |pmid= 17189266 |doi= 10.1074/jbc.M611048200 }}
*{{cite journal   |vauthors=Prante C, Milting H, Kassner A, etal |title=Transforming growth factor beta1-regulated xylosyltransferase I activity in human cardiac fibroblasts and its impact for myocardial remodeling. |journal=J. Biol. Chem. |volume=282 |issue= 36 |pages= 26441–9 |year= 2007 |pmid= 17635914 |doi= 10.1074/jbc.M702299200 }}
*{{cite journal | author=Prante C, Milting H, Kassner A, ''et al.'' |title=Transforming growth factor beta1-regulated xylosyltransferase I activity in human cardiac fibroblasts and its impact for myocardial remodeling. |journal=J. Biol. Chem. |volume=282 |issue= 36 |pages= 26441-9 |year= 2007 |pmid= 17635914 |doi= 10.1074/jbc.M702299200 }}
}}
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{{refend}}
{{refend}}
{{Glycosyltransferases}}
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Latest revision as of 21:46, 18 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Xylosyltransferase 1 is an enzyme that in humans is encoded by the XYLT1 gene.[1][2]

Xylosyltransferase (XT; EC 2.4.2.26) catalyzes the transfer of UDP-xylose to serine residues within XT recognition sequences of target proteins. Addition of this xylose to the core protein is required for the biosynthesis of the glycosaminoglycan chains characteristic of proteoglycans.[supplied by OMIM][2]

References

  1. ↑ Gotting C, Kuhn J, Zahn R, Brinkmann T, Kleesiek K (Jan 2001). "Molecular cloning and expression of human UDP-d-Xylose:proteoglycan core protein beta-d-xylosyltransferase and its first isoform XT-II". J Mol Biol. 304 (4): 517–28. doi:10.1006/jmbi.2000.4261. PMID 11099377.
  2. ↑ 2.0 2.1 "Entrez Gene: XYLT1 xylosyltransferase I".

Further reading



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