Wilson's disease physical examination

Jump to navigation Jump to search

Wilson's disease Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Wilson's disease from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Wilson's disease physical examination On the Web

Most recent articles

cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Wilson's disease physical examination

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Wilson's disease physical examination

CDC on Wilson's disease physical examination

Wilson's disease physical examination in the news

Blogs on Wilson's disease physical examination

Directions to Hospitals Treating Wilson's disease

Risk calculators and risk factors for Wilson's disease physical examination

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]

Overview

Patients with Wilson's disease usually appear tired. Physical examination of patients with Wilson's disease is usually remarkable for jaundice and easy bruising in the skin. Physical examination also is remarkable for Kayser Fleischer ring in the eyes as a result of the copper accumulation in the cornea. Common physical examination findings in the abdomen include abdominal tenderness , ascites, and spider angiomata. Common neurolopsychiatric signs include seizures, parkinsonism like signs, depression, and anxiety.

Physical examination

Appearance of the patient

  • Patients with Wilson's disease mostly appear tired due to the hepatic involvement.

Vitals

Skin

  • Jaundice
  • Easy bruising (bleeding tendency)

HEENT

  • Icteric sclera
  • Kayser Fleischer ring in the eyes

Abdomen

  • Abdominal tenderness
  • Hepatosplenomegaly
  • Ascites
  • Spider angiomata (in cases with cirrhosis)
  • Esophageal varices

Heart

  • Cardiomyopathy
  • Cardiac arrhythmia

Neuromuscular

  • Neurologic manifestations of Wilson's disease include the following:[1]
    • Parkinsonism like signs such as:
      • Bradykinesia
      • Cogwheel rigidity
      • Lack of balance
    • Seizures
    • Migrane
    • Frontal lobe disorder with the following signs:
      • Impaired judgement
      • Apathy
      • Poor planning
    • Psychiatric features such as:
      • Depression
      • Psychosis
      • Anxiety

References

  1. Lorincz MT (2010). "Neurologic Wilson's disease". Ann N Y Acad Sci. 1184: 173–87. doi:10.1111/j.1749-6632.2009.05109.x. PMID 20146697.