Warrior gene

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A version of the primate monoamine oxidase-A gene has been referred to as the warrior gene, initially in monkeys then in humans. Several different versions of the gene are found in different individuals, although a functional gene is present in most humans (except in a few individuals with Brunner syndrome).[1] There is not an additional warrior gene, rather the genotype associated with behavioural traits is shorter (30 bases) and may produce less MAO-A enzyme.[2] The variation in this case is actually in a regulatory promoter region about 1000 bases from the start of the region that encodes the MAO-A enzyme. However, research studies emphasise that behaviour is dependent on both genes and the environment.[3]

In 2006, a New Zealand researcher, Dr Rod Lea said that this variant (or genotype) of monoamine oxidase-A was over-represented in a small sample of current Māori.[4] This supported earlier studies that there are different proportions of variants in different ethnic groups. This is the case for many genetic variants, with 33% White/Non-Hispanic, 61% Asian/Pacific Islanders having the shorter promoter variant of the MAO-A gene.[2] This was subsequently discussed in a number of articles in the New Zealand Medical Journal.[5]

The reported suggestion that a single 'gene', in this case a variant of the MAO-A gene, is a significant factor in behaviour has been widely repudiated.[6][7][8]

References

  1. MONOAMINE OXIDASE A; MAOA.. Retrieved on 2006-08-14.
  2. 2.0 2.1 A functional polymorphism in the monoamine oxidase A gene promoter.. Retrieved on 2006-08-14.
  3. Role of genotype in the cycle of violence in maltreated children.. Retrieved on 2006-08-14.
  4. Maori 'warrior' gene linked to aggression
  5. The New Zealand Medical Journal, March 2007. Retrieved on 2007-09-27.
  6. Maori 'warrior gene' claims appalling, says geneticist
  7. Hui Report 2006, Keynote presentation by Moana Jackson
  8. Warrior genes and risk-taking science

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