WNT5A

Wingless-type MMTV integration site family, member 5A
Identifiers
Symbols	WNT5A ; hWNT5A
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20720
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Wingless-type MMTV integration site family, member 5A, also known as WNT5A, is a human gene.

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98%, 98% and 87% amino acid identity to the mouse, rat and the xenopus Wnt5A protein, respectively. The experiments performed in Xenopus laevis embryos identified that human frizzled-5 (hFz5) is the receptor for the Wnt5A ligand and the Wnt5A/hFz5 signaling mediates axis induction.

Further reading

• Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface". Mol. Biol. Cell. 4 (12): 1267–75. PMID 8167409.CS1 maint: Multiple names: authors list (link)
• Clark CC, Cohen I, Eichstetter I; et al. (1994). "Molecular cloning of the human proto-oncogene Wnt-5A and mapping of the gene (WNT5A) to chromosome 3p14-p21". Genomics. 18 (2): 249–60. doi:10.1006/geno.1993.1463. PMID 8288227.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Danielson KG, Pillarisetti J, Cohen IR; et al. (1996). "Characterization of the complete genomic structure of the human WNT-5A gene, functional analysis of its promoter, chromosomal mapping, and expression in early human embryogenesis". J. Biol. Chem. 270 (52): 31225–34. PMID 8537388.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• He X, Saint-Jeannet JP, Wang Y; et al. (1997). "A member of the Frizzled protein family mediating axis induction by Wnt-5A". Science. 275 (5306): 1652–4. PMID 9054360.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wright M, Aikawa M, Szeto W, Papkoff J (1999). "Identification of a Wnt-responsive signal transduction pathway in primary endothelial cells". Biochem. Biophys. Res. Commun. 263 (2): 384–8. doi:10.1006/bbrc.1999.1344. PMID 10491302.CS1 maint: Multiple names: authors list (link)
• Gazit A, Yaniv A, Bafico A; et al. (1999). "Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response". Oncogene. 18 (44): 5959–66. doi:10.1038/sj.onc.1202985. PMID 10557084.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Saitoh T, Mine T, Katoh M (2002). "Frequent up-regulation of WNT5A mRNA in primary gastric cancer". Int. J. Mol. Med. 9 (5): 515–9. PMID 11956659.CS1 maint: Multiple names: authors list (link)
• Weeraratna AT, Jiang Y, Hostetter G; et al. (2002). "Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma". Cancer Cell. 1 (3): 279–88. PMID 12086864.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Saitoh T, Katoh M (2003). "Expression and regulation of WNT5A and WNT5B in human cancer: up-regulation of WNT5A by TNFalpha in MKN45 cells and up-regulation of WNT5B by beta-estradiol in MCF-7 cells". Int. J. Mol. Med. 10 (3): 345–9. PMID 12165812.
• Murphy LL, Hughes CC (2002). "Endothelial cells stimulate T cell NFAT nuclear translocation in the presence of cyclosporin A: involvement of the wnt/glycogen synthase kinase-3 beta pathway". J. Immunol. 169 (7): 3717–25. PMID 12244165.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ishitani T, Kishida S, Hyodo-Miura J; et al. (2003). "The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling". Mol. Cell. Biol. 23 (1): 131–9. PMID 12482967.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hocevar BA, Mou F, Rennolds JL; et al. (2003). "Regulation of the Wnt signaling pathway by disabled-2 (Dab2)". EMBO J. 22 (12): 3084–94. doi:10.1093/emboj/cdg286. PMID 12805222.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Taki M, Kamata N, Yokoyama K; et al. (2004). "Down-regulation of Wnt-4 and up-regulation of Wnt-5a expression by epithelial-mesenchymal transition in human squamous carcinoma cells". Cancer Sci. 94 (7): 593–7. PMID 12841867.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Glinsky GV, Glinskii AB, Stephenson AJ; et al. (2004). "Gene expression profiling predicts clinical outcome of prostate cancer". J. Clin. Invest. 113 (6): 913–23. doi:10.1172/JCI200420032. PMID 15067324.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nishioka K, Dennis JE, Gao J; et al. (2005). "Sustained Wnt protein expression in chondral constructs from mesenchymal stem cells". J. Cell. Physiol. 203 (1): 6–14. doi:10.1002/jcp.20196. PMID 15389636.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Blanc E, Roux GL, Bénard J, Raguénez G (2005). "Low expression of Wnt-5a gene is associated with high-risk neuroblastoma". Oncogene. 24 (7): 1277–83. doi:10.1038/sj.onc.1208255. PMID 15592517.CS1 maint: Multiple names: authors list (link)
• Kremenevskaja N, von Wasielewski R, Rao AS; et al. (2005). "Wnt-5a has tumor suppressor activity in thyroid carcinoma". Oncogene. 24 (13): 2144–54. doi:10.1038/sj.onc.1208370. PMID 15735754.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)