Von Willebrand disease risk factors: Difference between revisions

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Revision as of 19:57, 29 August 2018

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Prince Tano Djan, BSc, MBChB [2]

Overview

There are no established risk factors for Von Willebrand disease however, individual's ABO blood group can influence presentation and pathology of vWD. Those individuals with blood group O have a lower mean level than individuals with other blood groups. Interestingly the risks of cardiovascular disease and ischemic stroke are reduced among patients with von Willebrand’s disease.

Risk factors

Common Risk Factors

Common risk factors in the development of Von Willebrand disease include:
- Positive family history
- Consanguineous relationships

Less Common Risk Factors

Less common risk factors in the development of Von Willebrand disease include:
Lymphoproliferative disorders
Aortic stenosis
Myeloproliferative disorders
Hypothyroidism

References

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 ==Overview==
-There are no established risk factors for Von Willebrand disease however, individual's [[ABO blood group system|ABO blood group]] can influence presentation and pathology of vWD. Those individuals with blood group O have a lower mean level than individuals with other blood groups.<ref>{{cite journal | last = Gill | first = JC | coauthors = Endres-Brooks J, Bauer PJ, Marks WJ, Montgomery RR | title = The effect of ABO blood group on the diagnosis of von Willebrand disease | journal = Blood | volume = 69 | issue = 6 | pages = 1691–5 | publisher = | date = 1987 | url = http://www.bloodjournal.org/cgi/content/abstract/69/6/1691 | doi = | pmid = 3495304 | accessdate =  }}</ref>
+There are no established risk factors for Von Willebrand disease however, individual's [[ABO blood group system|ABO blood group]] can influence presentation and pathology of vWD. Those individuals with blood group O have a lower mean level than individuals with other blood groups. Interestingly the risks of cardiovascular disease and ischemic stroke are reduced among patients with von Willebrand’s disease.
-Interestingly the risks of cardiovascular disease and ischemic stroke are reduced among patients with von Willebrand’s disease.<ref name="pmid23506463">{{cite journal| author=Sanders YV, Eikenboom J, de Wee EM, van der Bom JG, Cnossen MH, Degenaar-Dujardin ME et al.| title=Reduced prevalence of arterial thrombosis in von Willebrand disease. | journal=J Thromb Haemost | year= 2013 | volume= 11 | issue= 5 | pages= 845-54 | pmid=23506463 | doi=10.1111/jth.12194 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23506463  }} </ref><ref name="pmid26368360">{{cite journal| author=Seaman CD, Yabes J, Comer DM, Ragni MV| title=Does deficiency of von Willebrand factor protect against cardiovascular disease? Analysis of a national discharge register. | journal=J Thromb Haemost | year= 2015 | volume= 13 | issue= 11 | pages= 1999-2003 | pmid=26368360 | doi=10.1111/jth.13142 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26368360  }} </ref>
 ==Risk factors==
-There are no established risk factors for Von Willebrand disease however, individual's [[ABO blood group system|ABO blood group]] can influence presentation and pathology of vWD. Those individuals with blood group O have a lower mean level than individuals with other blood groups.<ref>{{cite journal | last = Gill | first = JC | coauthors = Endres-Brooks J, Bauer PJ, Marks WJ, Montgomery RR | title = The effect of ABO blood group on the diagnosis of von Willebrand disease | journal = Blood | volume = 69 | issue = 6 | pages = 1691–5 | publisher = | date = 1987 | url = http://www.bloodjournal.org/cgi/content/abstract/69/6/1691 | doi = | pmid = 3495304 | accessdate =  }}</ref>
+=== Common Risk Factors ===
-Interestingly the risks of cardiovascular disease and ischemic stroke are reduced among patients with von Willebrand’s disease.<ref name="pmid23506463">{{cite journal| author=Sanders YV, Eikenboom J, de Wee EM, van der Bom JG, Cnossen MH, Degenaar-Dujardin ME et al.| title=Reduced prevalence of arterial thrombosis in von Willebrand disease. | journal=J Thromb Haemost | year= 2013 | volume= 11 | issue= 5 | pages= 845-54 | pmid=23506463 | doi=10.1111/jth.12194 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23506463  }} </ref><ref name="pmid26368360">{{cite journal| author=Seaman CD, Yabes J, Comer DM, Ragni MV| title=Does deficiency of von Willebrand factor protect against cardiovascular disease? Analysis of a national discharge register. | journal=J Thromb Haemost | year= 2015 | volume= 13 | issue= 11 | pages= 1999-2003 | pmid=26368360 | doi=10.1111/jth.13142 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26368360  }} </ref>
+* Common risk factors in the development of Von Willebrand disease include:
+** Positive family history
+** Consanguineous relationships
+=== Less Common Risk Factors ===
+* Less common risk factors in the development of Von Willebrand disease include:
+* Lymphoproliferative disorders
+* Aortic stenosis
+* Myeloproliferative disorders
+* Hypothyroidism
 ==References==