Von Willebrand disease history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
The symptoms of von Willebrand’s disease vary among patients, depending on the level of residual von Willebrand factor activity, the disease subtype, and to some extent, age and sex.[1] Children with von Willebrand’s disease most frequently present with symptoms of bruising and epistaxis.[2]
Adults patients with vWD mainly present with bleeding after surgery (example bleeding after dental extraction/surgery), mucosa-associated bleeding, Heavy menstrual periods and postpartum hemorrhage. Severe internal or joint bleeding is rare (which only occurs in type 3 vWD). [3]
Symptoms
The symptoms of von Willebrand’s disease vary among patients, depending on the level of residual von Willebrand factor activity, the disease subtype, and to some extent, age and sex.[1]
Children
Children with von Willebrand’s disease most frequently present with symptoms of bruising and epistaxis.[2]
Adults
Adults patients with vWD mainly present with the following:[3]
- bleeding after surgery and trauma (The majority of patients (60 to 80%)
- Mucosa-associated bleeding
This usually may manifest in the form of the following:
- Easy bruising
- Nosebleeds
- Oral cavity bleeding
- Bleeding after dental extraction/surgery
- Heavy menstrual periods
- Postpartum hemorrhage.
- Severe internal or joint bleeding is rare (which only occurs in type 3 vWD).
To make a diagnosis, there is usually personal or family history of bleeding and laboratory evidence of defective von Willebrand factor, factor VIII, or both.
References
- ↑ 1.0 1.1 Nichols WL, Hultin MB, James AH, Manco-Johnson MJ, Montgomery RR, Ortel TL; et al. (2008). "von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA)". Haemophilia. 14 (2): 171–232. doi:10.1111/j.1365-2516.2007.01643.x. PMID 18315614.
- ↑ 2.0 2.1 Sanders YV, Fijnvandraat K, Boender J, Mauser-Bunschoten EP, van der Bom JG, de Meris J; et al. (2015). "Bleeding spectrum in children with moderate or severe von Willebrand disease: Relevance of pediatric-specific bleeding". Am J Hematol. 90 (12): 1142–8. doi:10.1002/ajh.24195. PMID 26375306.
- ↑ 3.0 3.1 de Wee EM, Sanders YV, Mauser-Bunschoten EP, van der Bom JG, Degenaar-Dujardin ME, Eikenboom J; et al. (2012). "Determinants of bleeding phenotype in adult patients with moderate or severe von Willebrand disease". Thromb Haemost. 108 (4): 683–92. doi:10.1160/TH12-04-0244. PMID 22918553.