Von Willebrand disease history and symptoms: Difference between revisions
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==Overview== | ==Overview== | ||
Adults patients with vWD mainly present with bleeding after | Patients with von Willebrand’s disease present with history of [[Mucosal bleeding|mucosal bleeding,]] recurrent nose bleeds, [[Oral cavity|oral cavity bleeding]], and positive family history of similer symptoms among other family members. Adults patients with vWD mainly present with bleeding after [[Extraction (dental)|dental extraction]]/ or other surgery. [[menorrhagia|Heavy menstrual periods]] and [[postpartum hemorrhage|postpartum hemorrhage]] are common among affected females with von Willebrand’s disease. Severe [[internal bleeding|internal]] or [[hemarthrosis|joint bleeding]] can occur but is usually rare. | ||
==Symptoms== | ==Symptoms== | ||
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=== History === | === History === | ||
Patients with von Willebrand’s disease may have a positive history of:<ref name="pmid18315614">{{cite journal| author=Nichols WL, Hultin MB, James AH, Manco-Johnson MJ, Montgomery RR, Ortel TL et al.| title=von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA). | journal=Haemophilia | year= 2008 | volume= 14 | issue= 2 | pages= 171-232 | pmid=18315614 | doi=10.1111/j.1365-2516.2007.01643.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18315614 }} </ref> | Patients with von Willebrand’s disease may have a positive history of:<ref name="pmid18315614">{{cite journal| author=Nichols WL, Hultin MB, James AH, Manco-Johnson MJ, Montgomery RR, Ortel TL et al.| title=von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA). | journal=Haemophilia | year= 2008 | volume= 14 | issue= 2 | pages= 171-232 | pmid=18315614 | doi=10.1111/j.1365-2516.2007.01643.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18315614 }} </ref> | ||
* | * Personal bleeding | ||
* Family history of bleeding | * Family history of bleeding | ||
* Bruising without obvious trauma | * [[Bruising]] without obvious [[trauma]] | ||
* Recurrent nose bleeds | * Recurrent nose bleeds | ||
* Oral cavity bleeding | * Oral cavity bleeding | ||
| Line 21: | Line 21: | ||
=== Common Symptoms === | === Common Symptoms === | ||
Common symptoms of von Willebrand’s disease include: | Common symptoms of von Willebrand’s disease include:<ref name="pmid30046704">{{cite journal |vauthors=Keesler DA, Flood VH |title=Current issues in diagnosis and treatment of von Willebrand disease |journal=Res Pract Thromb Haemost |volume=2 |issue=1 |pages=34–41 |date=January 2018 |pmid=30046704 |pmc=5974913 |doi=10.1002/rth2.12064 |url=}}</ref> | ||
* Easy [[bruising]] | * Easy [[bruising]] | ||
*[[Epistaxis|Nosebleeds]] | *[[Epistaxis|Nosebleeds]] | ||
| Line 31: | Line 31: | ||
=== Less Common Symptoms === | === Less Common Symptoms === | ||
Less common symptoms of von Willebrand’s disease include | Less common symptoms of von Willebrand’s disease include<ref name="pmid29878657">{{cite journal |vauthors=Leebeek FWG, Susen S |title=Von Willebrand disease: Clinical conundrums |journal=Haemophilia |volume=24 Suppl 6 |issue= |pages=37–43 |date=May 2018 |pmid=29878657 |doi=10.1111/hae.13508 |url=}}</ref> | ||
* Severe [[internal bleeding|internal]] [[hemarthrosis|bleeding]] | * Severe [[internal bleeding|internal]] [[hemarthrosis|bleeding]] | ||
* [[hemarthrosis|Joint bleeding]] | * [[hemarthrosis|Joint bleeding]] | ||
Revision as of 16:59, 31 August 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Prince Tano Djan, BSc, MBChB [2]
Overview
Patients with von Willebrand’s disease present with history of mucosal bleeding, recurrent nose bleeds, oral cavity bleeding, and positive family history of similer symptoms among other family members. Adults patients with vWD mainly present with bleeding after dental extraction/ or other surgery. Heavy menstrual periods and postpartum hemorrhage are common among affected females with von Willebrand’s disease. Severe internal or joint bleeding can occur but is usually rare.
Symptoms
History
Patients with von Willebrand’s disease may have a positive history of:[1]
- Personal bleeding
- Family history of bleeding
- Bruising without obvious trauma
- Recurrent nose bleeds
- Oral cavity bleeding
- Bleeding from the gums after brushing or flossing teeth
- Prolonged bleeding following dental cleaning or extractions.
Common Symptoms
Common symptoms of von Willebrand’s disease include:[2]
- Easy bruising
- Nosebleeds
- Oral cavity bleeding
- Bleeding after dental extraction/surgery
- Heavy menstrual periods
- Postpartum hemorrhage.
- Epistaxis
Less Common Symptoms
Less common symptoms of von Willebrand’s disease include[3]
- Severe internal bleeding
- Joint bleeding
- Gastrointestinal bleeding
References
- ↑ Nichols WL, Hultin MB, James AH, Manco-Johnson MJ, Montgomery RR, Ortel TL; et al. (2008). "von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA)". Haemophilia. 14 (2): 171–232. doi:10.1111/j.1365-2516.2007.01643.x. PMID 18315614.
- ↑ Keesler DA, Flood VH (January 2018). "Current issues in diagnosis and treatment of von Willebrand disease". Res Pract Thromb Haemost. 2 (1): 34–41. doi:10.1002/rth2.12064. PMC 5974913. PMID 30046704.
- ↑ Leebeek F, Susen S (May 2018). "Von Willebrand disease: Clinical conundrums". Haemophilia. 24 Suppl 6: 37–43. doi:10.1111/hae.13508. PMID 29878657. Vancouver style error: initials (help)