Vitamin K antagonist

File:Menaquinone.svg

Vitamin K₂ (menaquinone). In menaquinone the side chain is composed of a varying number of isoprenoid residues.

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List of terms related to Vitamin K antagonist

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Vitamin K antagonists (VKA) are a class of anticoagulants which, as their name indicates, act by inhibiting the action of vitamin K.

They can be teratogens.

Coumarins

Coumarins are the most commonly used VKA, and sometimes the terms are used synonymously.

In medicine, the most commonly used VKA is warfarin. The primary mechanism of warfarin is the inhibition of vitamin K epoxide reductase.

VKAs are also used as rodenticides.

• Warfarin or coumadin

  Warfarin or coumadin

• Coumatetralyl

  Coumatetralyl

• Phenprocoumon

  Phenprocoumon

• Dicoumarol

  Dicoumarol

Other VKAs

Not all VKAs are coumarins. For example, fluindione is a VKA, but not a coumarin.

Another example is phenindione.

Many of the non-coumarin VKAs are 1,3-indandione derivatives.

• Phenindione

  Phenindione

• Clorindione

  Clorindione

• 

  Diphenadione

Tioclomarol is another VKA, but it is neither a coumarin nor a diketone.

• 

  Tioclomarol

Related chapters

• Vitamin K deficiency

References

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