Urticaria laboratory findings: Difference between revisions
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==Laboratory Findings== | ==Laboratory Findings== | ||
*Autologous [[serum]] [[skin]] test (ASST) and [[Basophil granulocyte|basophil]] activation test (BAT) are two tests that are capable of detecting any [[Autoantibody|autoantibodies]] against [[Immunoglobulin E|IgE]] for FcεRI.<ref name="pmid31571935">{{cite journal| author=Puxeddu I, Petrelli F, Angelotti F, Croia C, Migliorini P| title=Biomarkers In Chronic Spontaneous Urticaria: Current Targets And Clinical Implications. | journal=J Asthma Allergy | year= 2019 | volume= 12 | issue= | pages= 285-295 | pmid=31571935 | doi=10.2147/JAA.S184986 | pmc=6759208 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=31571935 }} </ref><ref name="pmid26739404">{{cite journal| author=Ye YM, Park JW, Kim SH, Ban GY, Kim JH, Shin YS | display-authors=etal| title=Prognostic Factors for Chronic Spontaneous Urticaria: A 6-Month Prospective Observational Study. | journal=Allergy Asthma Immunol Res | year= 2016 | volume= 8 | issue= 2 | pages= 115-23 | pmid=26739404 | doi=10.4168/aair.2016.8.2.115 | pmc=4713874 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26739404 }} </ref> | |||
**Although ASST is not a [[Specificity (tests)|specific test]], positive results can determine active [[disease]], [[mast cells]] and [[Basophil granulocyte|basophils]] activation and possible reduction in [[Basophil granulocyte|basophils]]. | |||
**Interestingly positive autologous [[serum]] [[skin]] test (ASST) could be related to better [[prognosis]]. | |||
**Moreover positive autologous [[serum]] [[skin]] test (ASST) seems to be related to slower response to [[omalizumab]]. | |||
*[[C-reactive protein]] ([[C-reactive protein|CRP]]) is also related to [[disease]] activity and response to [[treatment]] in [[urticaria]].<ref name="pmid29130488">{{cite journal| author=Kolkhir P, Altrichter S, Hawro T, Maurer M| title=C-reactive protein is linked to disease activity, impact, and response to treatment in patients with chronic spontaneous urticaria. | journal=Allergy | year= 2018 | volume= 73 | issue= 4 | pages= 940-948 | pmid=29130488 | doi=10.1111/all.13352 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29130488 }} </ref> It's elevated level is associated with positive autologous [[serum]] [[skin]] test (ASST) and elevated levels of [[erythrocyte sedimentation rate]] ([[erythrocyte sedimentation rate|ESR]]), [[White blood cells|leukocytes]], [[neutrophils]] and [[Interleukin 6|IL-6]].<ref name="pmid21645137">{{cite journal| author=Kasperska-Zajac A, Sztylc J, Machura E, Jop G| title=Plasma IL-6 concentration correlates with clinical disease activity and serum C-reactive protein concentration in chronic urticaria patients. | journal=Clin Exp Allergy | year= 2011 | volume= 41 | issue= 10 | pages= 1386-91 | pmid=21645137 | doi=10.1111/j.1365-2222.2011.03789.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21645137 }} </ref> | |||
*Elevated level of [[Interleukin 6|IL-6]] is related to [[disease]] activity in [[urticaria]].<ref name="pmid21645137">{{cite journal| author=Kasperska-Zajac A, Sztylc J, Machura E, Jop G| title=Plasma IL-6 concentration correlates with clinical disease activity and serum C-reactive protein concentration in chronic urticaria patients. | journal=Clin Exp Allergy | year= 2011 | volume= 41 | issue= 10 | pages= 1386-91 | pmid=21645137 | doi=10.1111/j.1365-2222.2011.03789.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21645137 }} </ref> | |||
==References== | ==References== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Laboratory Findings
- Autologous serum skin test (ASST) and basophil activation test (BAT) are two tests that are capable of detecting any autoantibodies against IgE for FcεRI.[1][2]
- Although ASST is not a specific test, positive results can determine active disease, mast cells and basophils activation and possible reduction in basophils.
- Interestingly positive autologous serum skin test (ASST) could be related to better prognosis.
- Moreover positive autologous serum skin test (ASST) seems to be related to slower response to omalizumab.
- C-reactive protein (CRP) is also related to disease activity and response to treatment in urticaria.[3] It's elevated level is associated with positive autologous serum skin test (ASST) and elevated levels of erythrocyte sedimentation rate (ESR), leukocytes, neutrophils and IL-6.[4]
- Elevated level of IL-6 is related to disease activity in urticaria.[4]
References
- ↑ Puxeddu I, Petrelli F, Angelotti F, Croia C, Migliorini P (2019). "Biomarkers In Chronic Spontaneous Urticaria: Current Targets And Clinical Implications". J Asthma Allergy. 12: 285–295. doi:10.2147/JAA.S184986. PMC 6759208 Check
|pmc=value (help). PMID 31571935. - ↑ Ye YM, Park JW, Kim SH, Ban GY, Kim JH, Shin YS; et al. (2016). "Prognostic Factors for Chronic Spontaneous Urticaria: A 6-Month Prospective Observational Study". Allergy Asthma Immunol Res. 8 (2): 115–23. doi:10.4168/aair.2016.8.2.115. PMC 4713874. PMID 26739404.
- ↑ Kolkhir P, Altrichter S, Hawro T, Maurer M (2018). "C-reactive protein is linked to disease activity, impact, and response to treatment in patients with chronic spontaneous urticaria". Allergy. 73 (4): 940–948. doi:10.1111/all.13352. PMID 29130488.
- ↑ 4.0 4.1 Kasperska-Zajac A, Sztylc J, Machura E, Jop G (2011). "Plasma IL-6 concentration correlates with clinical disease activity and serum C-reactive protein concentration in chronic urticaria patients". Clin Exp Allergy. 41 (10): 1386–91. doi:10.1111/j.1365-2222.2011.03789.x. PMID 21645137.