Uremia: Difference between revisions

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Revision as of 05:17, 21 March 2009

Uremia
Urea
ICD-10 R39.2
ICD-9 585-586, 788.9
DiseasesDB 26060
eMedicine med/2341 
MeSH D014511

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [2] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.

Uremia is a term used to loosely describe the illness accompanying kidney failure. In kidney failure, urea and other waste products, which are normally excreted into the urine, are retained in the blood. Early symptoms include anorexia and lethargy, and late symptoms can include decreased mental acuity and coma. It is usually diagnosed in kidney dialysis patients when the glomerular filtration rate, a measure of kidney function, is below 50% of normal.[1]

Azotemia is another word that refers to high levels of urea, but is used primarily when the abnormality can be measured chemically but is not yet so severe as to produce symptoms. Uremia can also result in fibrinous pericarditis. There are many dysfunctions caused by uremia affecting many systems of the body, such as blood (lower levels of erythropoietin), Sex (lower levels of testosterone/oestrogen) and bones (osteoperosis and metastatic calcifications).

Causes

Besides renal failure, the level of urea in the blood can also be increased by:

  • increased production of urea in the liver, due to:
    • high protein diet
    • increased protein breakdown (surgery, infection, trauma, cancer)
    • gastrointestinal bleeding
    • drugs (e.g. tetracyclines and corticosteroids)
  • decreased elimination of urea, due to:
    • decreased blood flow through kidney (e.g. hypotension, cardiac failure)
    • urinary outflow obstruction
  • dehydration

See also


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Template:WikiDoc Sources

  1. Meyer TW and Hostetter, TH (2007). "Uremia". N Engl J Med. 357 (13): 1316. PMID 17898101. Full text.