Trypsin 1

Protease, serine, 1 (trypsin 1)
File:PBB Protein PRSS1 image.jpg PDB rendering based on 1trn.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1trn​
Identifiers
Symbols	PRSS1 ; MGC120175; MGC149362; TRP1; TRY1; TRY4; TRYP1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 68276
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PRSS1 205869 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Protease, serine, 1 (trypsin 1), also known as PRSS1, is a human gene.

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7.

See also

• Trypsin

Further reading

• Chen JM, Ferec C (2000). "Molecular basis of hereditary pancreatitis". Eur. J. Hum. Genet. 8 (7): 473–9. doi:10.1038/sj.ejhg.5200492. PMID 10909845.
• Chen JM, Ferec C (2000). "Gene conversion-like missense mutations in the human cationic trypsinogen gene and insights into the molecular evolution of the human trypsinogen family". Mol. Genet. Metab. 71 (3): 463–9. doi:10.1006/mgme.2000.3086. PMID 11073713.
• Chen JM, Montier T, Férec C (2001). "Molecular pathology and evolutionary and physiological implications of pancreatitis-associated cationic trypsinogen mutations". Hum. Genet. 109 (3): 245–52. doi:10.1007/s004390100580. PMID 11702203.CS1 maint: Multiple names: authors list (link)
• Howes N, Greenhalf W, Stocken DD, Neoptolemos JP (2005). "Cationic trypsinogen mutations and pancreatitis". Clin. Lab. Med. 25 (1): 39–59. doi:10.1016/j.cll.2004.12.004. PMID 15749231.CS1 maint: Multiple names: authors list (link)
• Kandula L, Whitcomb DC, Lowe ME (2006). "Genetic issues in pediatric pancreatitis". Current gastroenterology reports. 8 (3): 248–53. PMID 16764792.CS1 maint: Multiple names: authors list (link)
• Yamamoto KK, Pousette A, Chow P; et al. (1992). "Isolation of a cDNA encoding a human serum marker for acute pancreatitis. Identification of pancreas-specific protein as pancreatic procarboxypeptidase B.". J. Biol. Chem. 267 (4): 2575–81. PMID 1370825.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pollard SR, Meier W, Chow P; et al. (1992). "CD4-binding regions of human immunodeficiency virus envelope glycoprotein gp120 defined by proteolytic digestion". Proc. Natl. Acad. Sci. U.S.A. 88 (24): 11320–4. PMID 1763044.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shieh BH, Travis J (1987). "The reactive site of human alpha 2-antiplasmin". J. Biol. Chem. 262 (13): 6055–9. PMID 2437112.
• Kimland M, Russick C, Marks WH, Borgström A (1990). "Immunoreactive anionic and cationic trypsin in human serum". Clin. Chim. Acta. 184 (1): 31–46. PMID 2598466.CS1 maint: Multiple names: authors list (link)
• Emi M, Nakamura Y, Ogawa M; et al. (1986). "Cloning, characterization and nucleotide sequences of two cDNAs encoding human pancreatic trypsinogens". Gene. 41 (2–3): 305–10. PMID 3011602.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Honey NK, Sakaguchi AY, Quinto C; et al. (1984). "Chromosomal assignments of human genes for serine proteases trypsin, chymotrypsin B, and elastase". Somat. Cell Mol. Genet. 10 (4): 369–76. PMID 6589790.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Merrill GA, Butler M, Horowitz PM (1993). "Limited tryptic digestion near the amino terminus of bovine liver rhodanese produces active electrophoretic variants with altered refolding". J. Biol. Chem. 268 (21): 15611–20. PMID 8340386.CS1 maint: Multiple names: authors list (link)
• Rowen L, Koop BF, Hood L (1996). "The complete 685-kilobase DNA sequence of the human beta T cell receptor locus". Science. 272 (5269): 1755–62. PMID 8650574.CS1 maint: Multiple names: authors list (link)
• Gaboriaud C, Serre L, Guy-Crotte O; et al. (1996). "Crystal structure of human trypsin 1: unexpected phosphorylation of Tyr151". J. Mol. Biol. 259 (5): 995–1010. doi:10.1006/jmbi.1996.0376. PMID 8683601.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Whitcomb DC, Gorry MC, Preston RA; et al. (1996). "Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene". Nat. Genet. 14 (2): 141–5. doi:10.1038/ng1096-141. PMID 8841182.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gu M, Majerus PW (1996). "The properties of the protein tyrosine phosphatase PTPMEG". J. Biol. Chem. 271 (44): 27751–9. PMID 8910369.
• Christensen S, Valnickova Z, Thogersen IB; et al. (1997). "Assignment of a single disulphide bridge in human alpha2-antiplasmin: implications for the structural and functional properties". Biochem. J. 323 ( Pt 3): 847–52. PMID 9169621.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gorry MC, Gabbaizedeh D, Furey W; et al. (1997). "Mutations in the cationic trypsinogen gene are associated with recurrent acute and chronic pancreatitis". Gastroenterology. 113 (4): 1063–8. PMID 9322498.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dahlen JR, Foster DC, Kisiel W (1998). "Expression, purification, and inhibitory properties of human proteinase inhibitor". Biochemistry. 36 (48): 14874–82. doi:10.1021/bi970977p. PMID 9402754.CS1 maint: Multiple names: authors list (link)
• Teich N, Mössner J, Keim V (1998). "Mutations of the cationic trypsinogen in hereditary pancreatitis". Hum. Mutat. 12 (1): 39–43. doi:10.1002/(SICI)1098-1004(1998)12:1<39::AID-HUMU6>3.0.CO;2-P. PMID 9633818.CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.