Tropomyosin 3

Tropomyosin 3
File:PBB Protein TPM3 image.jpg PDB rendering based on 1mv4.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1mv4​, 2g9j​, 2tma​
Identifiers
Symbols	TPM3 ; NEM1; TRK; FLJ41118; MGC14582; MGC3261; MGC72094; OK/SW-cl.5; TM-5; TM3; TM30; TM30nm; TPMsk3; hscp30
External IDs	Template:OMIM5 HomoloGene: 77475
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Tropomyosin 3, also known as TPM3, is a human gene.

This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Further reading

• Lees-Miller JP, Helfman DM (1992). "The molecular basis for tropomyosin isoform diversity". Bioessays. 13 (9): 429–37. doi:10.1002/bies.950130902. PMID 1796905.
• Pittenger MF, Kazzaz JA, Helfman DM (1994). "Functional properties of non-muscle tropomyosin isoforms". Curr. Opin. Cell Biol. 6 (1): 96–104. PMID 8167032.CS1 maint: Multiple names: authors list (link)
• Gunning P, Weinberger R, Jeffrey P (1997). "Actin and tropomyosin isoforms in morphogenesis". Anat. Embryol. 195 (4): 311–5. PMID 9108196.CS1 maint: Multiple names: authors list (link)
• Gunning PW, Schevzov G, Kee AJ, Hardeman EC (2006). "Tropomyosin isoforms: divining rods for actin cytoskeleton function". Trends Cell Biol. 15 (6): 333–41. doi:10.1016/j.tcb.2005.04.007. PMID 15953552.CS1 maint: Multiple names: authors list (link)
• Rasmussen HH, van Damme J, Puype M; et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis. 13 (12): 960–9. PMID 1286667.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Höner B, Shoeman RL, Traub P (1992). "Degradation of cytoskeletal proteins by the human immunodeficiency virus type 1 protease". Cell Biol. Int. Rep. 16 (7): 603–12. PMID 1516138.CS1 maint: Multiple names: authors list (link)
• Morris CM, Hao QL, Heisterkamp N; et al. (1991). "Localization of the TRK proto-oncogene to human chromosome bands 1q23-1q24". Oncogene. 6 (6): 1093–5. PMID 1829807.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Winder SJ, Walsh MP (1990). "Smooth muscle calponin. Inhibition of actomyosin MgATPase and regulation by phosphorylation". J. Biol. Chem. 265 (17): 10148–55. PMID 2161834.
• Takahashi K, Hiwada K, Kokubu T (1988). "Vascular smooth muscle calponin. A novel troponin T-like protein". Hypertension. 11 (6 Pt 2): 620–6. PMID 2455687.CS1 maint: Multiple names: authors list (link)
• Coulier F, Martin-Zanca D, Ernst M, Barbacid M (1989). "Mechanism of activation of the human trk oncogene". Mol. Cell. Biol. 9 (1): 15–23. PMID 2538716.CS1 maint: Multiple names: authors list (link)
• Martin-Zanca D, Hughes SH, Barbacid M (1986). "A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences". Nature. 319 (6056): 743–8. doi:10.1038/319743a0. PMID 2869410.CS1 maint: Multiple names: authors list (link)
• Reinach FC, MacLeod AR (1986). "Tissue-specific expression of the human tropomyosin gene involved in the generation of the trk oncogene". Nature. 322 (6080): 648–50. doi:10.1038/322648a0. PMID 3018581.
• MacLeod AR, Houlker C, Reinach FC, Talbot K (1987). "The mRNA and RNA-copy pseudogenes encoding TM30nm, a human cytoskeletal tropomyosin". Nucleic Acids Res. 14 (21): 8413–26. PMID 3024106.CS1 maint: Multiple names: authors list (link)
• Clayton L, Reinach FC, Chumbley GM, MacLeod AR (1988). "Organization of the hTMnm gene. Implications for the evolution of muscle and non-muscle tropomyosins". J. Mol. Biol. 201 (3): 507–15. PMID 3418707.CS1 maint: Multiple names: authors list (link)
• MacLeod AR, Houlker C, Reinach FC; et al. (1986). "A muscle-type tropomyosin in human fibroblasts: evidence for expression by an alternative RNA splicing mechanism". Proc. Natl. Acad. Sci. U.S.A. 82 (23): 7835–9. PMID 3865200.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Butti MG, Bongarzone I, Ferraresi G; et al. (1995). "A sequence analysis of the genomic regions involved in the rearrangements between TPM3 and NTRK1 genes producing TRK oncogenes in papillary thyroid carcinomas". Genomics. 28 (1): 15–24. doi:10.1006/geno.1995.1100. PMID 7590742.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Laing NG, Wilton SD, Akkari PA; et al. (1995). "A mutation in the alpha tropomyosin gene TPM3 associated with autosomal dominant nemaline myopathy NEM1". Nat. Genet. 10 (2): 249. doi:10.1038/ng0695-249. PMID 7663526.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Laing NG, Wilton SD, Akkari PA; et al. (1995). "A mutation in the alpha tropomyosin gene TPM3 associated with autosomal dominant nemaline myopathy". Nat. Genet. 9 (1): 75–9. doi:10.1038/ng0195-75. PMID 7704029.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wilton SD, Eyre H, Akkari PA; et al. (1994). "Assignment of the human a-tropomyosin gene TPM3 to 1q22-->q23 by fluorescence in situ hybridisation". Cytogenet. Cell Genet. 68 (1–2): 122–4. PMID 7956350.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)