Thyroid adenoma pathophysiology: Difference between revisions

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# the cellularity of the adenoma
# the cellularity of the adenoma
# the colloid content.
# the colloid content.
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Image:Follicular adenoma.png|ADRENAL GLAND: BILATERAL PHEOCHROMOCYTOMA Cross section of bilateral pheochromocytomas from a 30-year-old man with MEN syndrome type IIa. The right adrenal tumor weighed 168 g and the left 220 g. Note the distinct multinodular, multicentric pattern of growth on both sides
==Microscopic Pathology==
==Microscopic Pathology==
Areas of hemorrhage, fibrosis, calcification, and cystic change, similar to what is found in multinodular goiters, are common in thyroid (follicular) adenoma, particularly in larger lesions.
Areas of hemorrhage, fibrosis, calcification, and cystic change, similar to what is found in multinodular goiters, are common in thyroid (follicular) adenoma, particularly in larger lesions.
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Image:Follicular adenoma.png|ADRENAL GLAND: BILATERAL PHEOCHROMOCYTOMA Cross section of bilateral pheochromocytomas from a 30-year-old man with MEN syndrome type IIa. The right adrenal tumor weighed 168 g and the left 220 g. Note the distinct multinodular, multicentric pattern of growth on both sides
Image:Follicular Adenoma of the Thyroid Gland.jpg|Follicular Adenoma of the Thyroid Gland
Image:Micropathology.jpg|Histology of the encapsulated tumor. (a) Photomicrograph showing an encapsulated tumor composed of cells arranged in microfollicular, glandular and trabecular patterns (hematoxylin and eosin; 100×). (b) High power photomicrograph showing the microfollicles containing inspissated colloid resembling hyaline globules and separated by eosinophilic extracellular hyaline material. (hematoxylin and eosin; 100×).<ref name=radio02>Image courtesy of Dr Frank Gaillard. [http://www.jmedicalcasereports.com/content/8/1/270] (original file[http://www.jmedicalcasereports.com/content/8/1/270‘’here’’]).[http://www.jmedicalcasereports.com/content/8/1/270/licence Creative Commons BY-SA-NC]</ref>
<ref name=radio02>Image courtesy of Dr Frank Gaillard. [http://www.jmedicalcasereports.com/content/8/1/270] (original file[http://www.jmedicalcasereports.com/content/8/1/270‘’here’’]).[http://www.jmedicalcasereports.com/content/8/1/270/licence Creative Commons BY-SA-NC]</ref>
Image:Microfollicular stain.jpg|(a) Cytoplasmic and membrane positivity for cytokeratin 7 immunostain (400×); (b)negativity for cytokeratin 20 immunostain (400×); (c) nuclear positivity for retinoblastoma immunostain (400×); and (d) extracellular positivity for collagen type IV immunostain (400×).<ref name=radio02>Image courtesy of Dr Frank Gaillard. [http://www.jmedicalcasereports.com/content/8/1/270] (original file[http://www.jmedicalcasereports.com/content/8/1/270‘’here’’]).[http://www.jmedicalcasereports.com/content/8/1/270/licence Creative Commons BY-SA-NC]</ref>
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Revision as of 18:46, 7 October 2015

Thyroid adenoma Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Overview

Pathogenesis

A thyroid adenoma may be clinically silent, or it may be a "functional" tumor, producing excessive thyroid hormone. In this case, it may result in symptomatic hyperthyroidism, and may be referred to as a toxic thyroid adenoma. Careful pathological examination may be necessary to distinguish a thyroid adenoma from a minimally invasive follicular thyroid carcinoma.

Colloid Nodules

Colloid nodules (CN) are non-neoplastic benign nodules occurring within the thyroid gland. They form the vast majority of nodular thyroid disease. Colloid nodules are composed of irregularly enlarged follicles containing abundant colloid. Some colloid nodules can be cystic (cystic colloid nodule), and may contain areas of necrosis, haemorrhage and/or calcification. Colloid nodule may be single or multiple and can vary considerably in size.[1]

Genetics

Associated Conditions

Gross Pathology

Thyroid follicular adenoma ranges in diameter from 3 cm on an average, but sometimes is larger (up to 10 cm) or smaller. The typical thyroid adenoma is solitary, spherical and encapsulated lesion that is well demarcated from the surrounding parenchyma. The color ranges from gray-white to red-brown, depending upon

  1. the cellularity of the adenoma
  2. the colloid content.

Histopathological Video

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Reference

  1. Colloid nodule (thyroid). Radiopedia 2015. http://radiopaedia.org/articles/colloid-nodule-thyroid-1 Accessed on October,7, 2015