Thyroid adenoma biopsy
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [3]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [4]
Overview
Fine needle aspiration biopsy may be helpful in diagnosis of thyroid adenoma. Findings on fine needle aspiration biopsy suggestive of thyroid adenoma include cystic changes, fibrosis, and areas of hemorrhage.
Biopsy
- One approach used to determine the type of adenoma is fine needle biopsy (FNB), which some have described as the most cost-effective, sensitive, and accurate test.[1][2]
- Fine needle aspiration biopsy or ultrasound-guided fine needle aspiration biopsy usually yields sufficient thyroid cells to assess the pathology, although in some cases, the suspected nodule may need to be removed surgically for pathological examination.
Key Biopsy Findings in Thyroid adenoma
- Areas of hemorrhage, fibrosis, calcification, and cystic change are common in thyroid (follicular) adenoma, particularly in larger lesions.
- Encapsulated tumors do not have any evidence of infiltration.
- Colloid nodules are distinguished by an apparently gelatinous mass of colloid both surrounding and contained within follicular cells. Colloid nodules are not surrounded by a fibrous capsule of compressed tissue. However, they are surrounded by flattened epithelial cells.[3] Both the number of cells and the type of colloid may vary considerably.[4]
Biopsy Exams of Thyroid adenoma
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Follicular adenoma of the thyroid gland
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![Histology of the encapsulated tumor. (a) Photomicrograph showing an encapsulated tumor composed of cells arranged in microfollicular, glandular and trabecular patterns (hematoxylin and eosin; 100×). (b) High power photomicrograph showing the microfollicles containing inspissated colloid resembling hyaline globules and separated by eosinophilic extracellular hyaline material. (hematoxylin and eosin; 100×).[5]](/images/d/dc/Micropathology.jpg)
Histology of the encapsulated tumor. (a) Photomicrograph showing an encapsulated tumor composed of cells arranged in microfollicular, glandular and trabecular patterns (hematoxylin and eosin; 100×). (b) High power photomicrograph showing the microfollicles containing inspissated colloid resembling hyaline globules and separated by eosinophilic extracellular hyaline material. (hematoxylin and eosin; 100×).[5]
![Histology of the encapsulated tumor. (a) Photomicrograph showing an encapsulated tumor composed of cells arranged in microfollicular, glandular and trabecular patterns (hematoxylin and eosin; 100×). (b) High power photomicrograph showing the microfollicles containing inspissated colloid resembling hyaline globules and separated by eosinophilic extracellular hyaline material. (hematoxylin and eosin; 100×).[5]](/index.php/File:Micropathology.jpg){kind=small}
References
- ↑ Hamberger, B (1982). "Fine-needle aspiration biopsy of thyroid nodules. Impact on thyroid practice and cost of care". Am J Med. 73 (3): 381–384. doi:10.1016/0002-9343(82)90731-8. PMID 7124765.
- ↑ Mazzaferri (1993). "Management of a Solitary Thyroid Nodule". N Engl J Med. 328 (8): 553–9. doi:10.1056/NEJM199302253280807. PMID 8426623.
- ↑ Dr. Alpha Tsui (10 October 2010). "Thyroid cytology" (PDF). thyroidmanager.org. Retrieved 26 September 2011.
- ↑ Diana S. Dean, M.D. Hossein Gharib, M.D. (10 October 2010). "Fine-Needle Aspiration Biopsy of the Thyroid Gland, Chapter 6d". thyroidmanager.org. Retrieved 26 September 2011.
- ↑ Image courtesy of Dr Frank Gaillard. [1] (original file[2]).Creative Commons BY-SA-NC