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| ==Overview== | | ==Overview== |
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| [[Needle aspiration biopsy|Fine needle aspiration biopsy]] may be helpful in the [[diagnosis]] of thyroid adenoma. Findings on fine needle aspiration biopsy suggestive of thyroid adenoma include cystic changes, [[fibrosis]], and areas of [[hemorrhage]].
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| ==Biopsy==
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| * One approach used to determine the type of adenoma is fine needle biopsy (FNB), which some have described as the most cost-effective, sensitive, and accurate test.<ref>
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| {{cite journal
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| | last = Hamberger
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| | first = B
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| | year = 1982
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| | title = Fine-needle aspiration biopsy of thyroid nodules. Impact on thyroid practice and cost of care
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| | journal = Am J Med
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| | volume = 73
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| | pages = 381–384
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| | pmid = 7124765
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| | doi=10.1016/0002-9343(82)90731-8
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| | issue=3
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| }}
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| </ref><ref>
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| {{cite journal
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| | last = Mazzaferri
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| | year = 1993
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| | title = Management of a Solitary Thyroid Nodule
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| | journal = N Engl J Med
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| | volume = 328
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| | pages = 553–9
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| | pmid = 8426623
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| | doi=10.1056/NEJM199302253280807
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| | issue=8
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| }}
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| </ref>
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| * [[Needle aspiration biopsy|Fine needle aspiration biopsy]] or ultrasound-guided [[Needle aspiration biopsy|fine needle aspiration biopsy]] usually yields sufficient thyroid cells to assess the [[pathology]], although in some cases, the suspected nodule may need to be removed surgically for pathological examination.
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| ===Key Biopsy Findings in Thyroid adenoma===
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| * Areas of [[hemorrhage]], [[fibrosis]], [[calcification]], and cystic change are common in thyroid (follicular) adenoma, particularly in larger lesions.
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| * Encapsulated [[tumor]]s do not have any evidence of infiltration.
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| * Colloid nodules are distinguished by an apparently gelatinous mass of [[colloid]] both surrounding and contained within [[follicular cell]]s. Colloid nodules are not surrounded by a [[fibrous capsule]] of compressed tissue. However, they are surrounded by flattened [[epithelium|epithelial]] cells.<ref>{{cite web |url=http://rcpa.tv/parts/educational/anatomical/Dr_Alpha_Tsui/Thyroid_cytology.pdf |title=Thyroid cytology |author=Dr. Alpha Tsui |date=10 October 2010 |publisher=thyroidmanager.org |accessdate=26 September 2011}}</ref> Both the number of cells and the type of colloid may vary considerably.<ref>{{cite web |url=http://www.thyroidmanager.org/chapter%206d/fnabiopsy-frame.htm |title=Fine-Needle Aspiration Biopsy of the Thyroid Gland, Chapter 6d. |author=Diana S. Dean, M.D. Hossein Gharib, M.D. |date=10 October 2010 |publisher=thyroidmanager.org |accessdate=26 September 2011}}</ref>
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| {{Familytree/start}}
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| {{Familytree|boxstyle=background: #E0FFFF;| | | | | | | | | | | | | | A01 | | | | | | | | | | | | | | | | | | |A01= A patient with thyroid nodule}}
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| {{Familytree|boxstyle=background: #E0FFFF;| | | | | | | | | |,|-|-|-|-|^|-|-|-|-|.| | | | | | | | | | | | | | | | | | |}}
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| {{Familytree|boxstyle=background: #E0FFFF;| | | | | | | | | B01 | | | | | | | | B02 | | | | | | | | | | | | | | | |B01= Normal [[thyroid stimulating hormone]]|B02= Low [[thyroid stimulating hormone]]|}}
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| {{Familytree|boxstyle=background: #E0FFFF;| | | | | | |,|-|-|^|-|.| | | | | | | |!| | | | | | | | | | | | | | |}}
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| {{Familytree|boxstyle=background: #E0FFFF;| | | | | | C01 | | | C02 | | | | | | C03 | | | | | | | | | | | | | | | | | |C01= <1cm suspicious nodule|C02= >1cm nodule|C03=Thyroid nuclear scan}}
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| {{Familytree|boxstyle=background: #E0FFFF;| | | | | | |!| | | | |!| | | | |,|-|-|^|-|-|-|.| | | | | | | | | | | | | | | | | | | |}}
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| {{Familytree|boxstyle=background: #E0FFFF;| | | | | | D01 | | | D02 | | | | D03 | | | | D04 | | | | | | | | | | | | | | |D01= Ultrasound guided fine needle aspiration cytology|D02= Fine needle aspiration cytology|D03= Hot nodule|D04= Cold nodule}}{{Familytree|boxstyle=background: #E0FFFF;| | | | | | | | | | | | | | | | | | | | | | | |!| | | | | | | | | | | |}}
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| {{Familytree|boxstyle=background: #E0FFFF;| | | | | | | | | | | | | | | | | | | | | | | E05 | | | | | | | | | | | |E05= Fine needle aspiration cytology}}
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| {{Familytree/end}}
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| ==References== | | ==References== |