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| __NOTOC__
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| {{Thyroid adenoma}}
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| {{CMG}}; {{AE}} {{Ammu}}
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| ==Overview==
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| [[Needle aspiration biopsy|Fine needle aspiration biopsy]] may be helpful in [[diagnosis]] of thyroid adenoma. Findings on fine needle aspiration biopsy suggestive of thyroid adenoma include cystic changes, [[fibrosis]], and areas of [[hemorrhage]].
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| ==Biopsy==
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| * One approach used to determine type of adenoma is fine needle biopsy (FNB), which some have described as the most cost-effective, sensitive, and accurate test.<ref>
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| {{cite journal
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| | last = Hamberger
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| | first = B
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| | year = 1982
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| | title = Fine-needle aspiration biopsy of thyroid nodules. Impact on thyroid practice and cost of care
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| | journal = Am J Med
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| | volume = 73
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| | pages = 381–384
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| | pmid = 7124765
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| | doi=10.1016/0002-9343(82)90731-8
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| | issue=3
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| }}
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| </ref><ref>
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| {{cite journal
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| | last = Mazzaferri
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| | year = 1993
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| | title = Management of a Solitary Thyroid Nodule
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| | journal = N Engl J Med
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| | volume = 328
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| | pages = 553–9
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| | pmid = 8426623
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| | doi=10.1056/NEJM199302253280807
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| | issue=8
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| }}
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| </ref>
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| * [[Needle aspiration biopsy|Fine needle aspiration biopsy]] or ultrasound-guided [[Needle aspiration biopsy|Fine needle aspiration biopsy]] usually yields sufficient thyroid cells to assess the [[pathology]], although in some cases, the suspected nodule may need to be removed surgically for pathological examination.
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| ===Key Biopsy Findings in Thyroid adenoma===
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| * Areas of [[hemorrhage]], [[fibrosis]], [[calcification]], and cystic change are common in thyroid (follicular) adenoma, particularly in larger lesions.
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| * Encapsulated [[tumor]]s do not have any evidence of infiltration.
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| * Colloid nodules are distinguished by an apparently gelatinous mass of [[colloid]] both surrounding and contained within [[follicular cell]]s. Colloid nodules are not surrounded by a [[fibrous capsule]] of compressed tissue. However, they are surrounded by flattened [[epithelium|epithelial]] cells.<ref>{{cite web |url=http://rcpa.tv/parts/educational/anatomical/Dr_Alpha_Tsui/Thyroid_cytology.pdf |title=Thyroid cytology |author=Dr. Alpha Tsui |date=10 October 2010 |publisher=thyroidmanager.org |accessdate=26 September 2011}}</ref> Both the number of cells and the type of colloid may vary considerably.<ref>{{cite web |url=http://www.thyroidmanager.org/chapter%206d/fnabiopsy-frame.htm |title=Fine-Needle Aspiration Biopsy of the Thyroid Gland, Chapter 6d. |author=Diana S. Dean, M.D. Hossein Gharib, M.D. |date=10 October 2010 |publisher=thyroidmanager.org |accessdate=26 September 2011}}</ref>
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| ===Biopsy Exams of Thyroid adenoma===
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| <gallery>
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| Image:Follicular adenoma.png|Follicular adenoma of the thyroid gland
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| Image:Micropathology.jpg|Histology of the encapsulated tumor. (a) Photomicrograph showing an encapsulated tumor composed of cells arranged in microfollicular, glandular and trabecular patterns (hematoxylin and eosin; 100×). (b) High power photomicrograph showing the microfollicles containing inspissated colloid resembling hyaline globules and separated by eosinophilic extracellular hyaline material. (hematoxylin and eosin; 100×).<ref name=radio02>Image courtesy of Dr Frank Gaillard. [http://www.jmedicalcasereports.com/content/8/1/270] (original file[http://www.jmedicalcasereports.com/content/8/1/270‘’here’’]).[http://www.jmedicalcasereports.com/content/8/1/270/licence Creative Commons BY-SA-NC]</ref>
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| </gallery>
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| ==References==
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| {{reflist|2}}
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| {{WH}}
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| {{WS}}
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| [[Category:Disease]]
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| [[Category:Endocrinology]]
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