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| __NOTOC__
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| {{Thyroid adenoma}}
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| {{CMG}}; {{AE}} {{Ammu}}
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| ==Overview==
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| ==Biopsy==
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| * One approach used to determine type of adenoma is fine needle biopsy (FNB), which some have described as the most cost-effective, sensitive and accurate test.<ref>
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| {{cite journal
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| | last = Hamberger
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| | first = B
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| | year = 1982
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| | title = Fine-needle aspiration biopsy of thyroid nodules. Impact on thyroid practice and cost of care
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| | journal = Am J Med
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| | volume = 73
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| | pages = 381–384
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| | pmid = 7124765
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| | doi=10.1016/0002-9343(82)90731-8
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| | issue=3
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| }}
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| </ref><ref>
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| {{cite journal
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| | last = Mazzaferri
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| | year = 1993
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| | title = Management of a Solitary Thyroid Nodule
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| | journal = N Engl J Med
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| | volume = 328
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| | pages = 553–9
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| | pmid = 8426623
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| | doi=10.1056/NEJM199302253280807
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| | issue=8
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| }}
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| </ref>
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| * Fine needle biopsy (FNB) or ultrasound-guided fine needle aspiration usually yields sufficient thyroid cells to assess the pathology, although in some cases, the suspected nodule may need to be removed surgically for pathological examination. The report may be done according to the Bethesda System for Reporting Thyroid Cytopathology.
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| ===Key Biopsy Findings in Thyroid adenoma===
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| * Areas of hemorrhage, fibrosis, calcification, and cystic change, similar to what is found in multinodular goiters, are common in thyroid (follicular) adenoma, particularly in larger lesions.
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| * Encapsulated tumors without evidence of infiltration
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| * Colloid nodules are distinguished by an apparently gelatinous mass of [[colloid]] both surrounding and contained within [[follicular cell]]s. Colloid nodules are not surrounded by a fibrous capsule of compressed tissue. However, they are surrounded by flattened [[epithelium|epithelial]] cells.<ref>{{cite web |url=http://rcpa.tv/parts/educational/anatomical/Dr_Alpha_Tsui/Thyroid_cytology.pdf |title=Thyroid cytology |author=Dr. Alpha Tsui |date=10 October 2010 |publisher=thyroidmanager.org |accessdate=26 September 2011}}</ref> Both the number of cells and the type of colloid may vary considerably.<ref>{{cite web |url=http://www.thyroidmanager.org/chapter%206d/fnabiopsy-frame.htm |title=Fine-Needle Aspiration Biopsy of the Thyroid Gland, Chapter 6d. |author=Diana S. Dean, M.D. Hossein Gharib, M.D. |date=10 October 2010 |publisher=thyroidmanager.org |accessdate=26 September 2011}}</ref>
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| ===Biopsy Exams of Thyroid adenoma===
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| <gallery>
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| Image:Follicular adenoma.png|Follicular adenoma of the thyroid gland
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| Image:Micropathology.jpg|Histology of the encapsulated tumor. (a) Photomicrograph showing an encapsulated tumor composed of cells arranged in microfollicular, glandular and trabecular patterns (hematoxylin and eosin; 100×). (b) High power photomicrograph showing the microfollicles containing inspissated colloid resembling hyaline globules and separated by eosinophilic extracellular hyaline material. (hematoxylin and eosin; 100×).<ref name=radio02>Image courtesy of Dr Frank Gaillard. [http://www.jmedicalcasereports.com/content/8/1/270] (original file[http://www.jmedicalcasereports.com/content/8/1/270‘’here’’]).[http://www.jmedicalcasereports.com/content/8/1/270/licence Creative Commons BY-SA-NC]</ref>
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| </gallery>
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| ==References==
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| {{reflist|2}}
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| {{WH}}
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| {{WS}}
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| [[Category:Disease]]
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| [[Category:Endocrinology]]
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