Thrombotic thrombocytopenic purpura risk factors: Difference between revisions

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__NOTOC__
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{{Thrombotic thrombocytopenic purpura}}
{{Thrombotic thrombocytopenic purpura}}
{{CMG}}
{{CMG}} {{AE}} {{S.G.}}


==Overview==
==Overview==
The most potent [[risk factor]] in the development of TTP is black ethnicity. Other [[Risk factor|risk factors]] include famale gender, [[pregnancy]], obseity, [[chemotherapy]], [[infection]] and etc.
==Risk Factors==
==Risk Factors==
===Common Risk Factors===
===Common Risk Factors===
Common risk factors in the development of TTP may be occupational, environmental, genetic, and viral.
Common risk factors in the development of TTP include:<ref name="pmid27383202">{{cite journal |vauthors=Martino S, Jamme M, Deligny C, Busson M, Loiseau P, Azoulay E, Galicier L, Pène F, Provôt F, Dossier A, Saheb S, Veyradier A, Coppo P |title=Thrombotic Thrombocytopenic Purpura in Black People: Impact of Ethnicity on Survival and Genetic Risk Factors |journal=PLoS ONE |volume=11 |issue=7 |pages=e0156679 |date=2016 |pmid=27383202 |pmc=4934773 |doi=10.1371/journal.pone.0156679 |url=}}</ref><ref name="NicolShelton2003">{{cite journal|last1=Nicol|first1=Kathleen K.|last2=Shelton|first2=Brent J.|last3=Knovich|first3=Mary Ann|last4=Owen|first4=John|title=Overweight individuals are at increased risk for thrombotic thrombocytopenic purpura|journal=American Journal of Hematology|volume=74|issue=3|year=2003|pages=170–174|issn=0361-8609|doi=10.1002/ajh.10418}}</ref><ref name="pmid24859360">{{cite journal |vauthors=Scully M, Thomas M, Underwood M, Watson H, Langley K, Camilleri RS, Clark A, Creagh D, Rayment R, Mcdonald V, Roy A, Evans G, McGuckin S, Ni Ainle F, Maclean R, Lester W, Nash M, Scott R, O Brien P |title=Thrombotic thrombocytopenic purpura and pregnancy: presentation, management, and subsequent pregnancy outcomes |journal=Blood |volume=124 |issue=2 |pages=211–9 |date=July 2014 |pmid=24859360 |doi=10.1182/blood-2014-02-553131 |url=}}</ref>
Common risk factors in the development of TTP include:<ref name="pmid27383202">{{cite journal |vauthors=Martino S, Jamme M, Deligny C, Busson M, Loiseau P, Azoulay E, Galicier L, Pène F, Provôt F, Dossier A, Saheb S, Veyradier A, Coppo P |title=Thrombotic Thrombocytopenic Purpura in Black People: Impact of Ethnicity on Survival and Genetic Risk Factors |journal=PLoS ONE |volume=11 |issue=7 |pages=e0156679 |date=2016 |pmid=27383202 |pmc=4934773 |doi=10.1371/journal.pone.0156679 |url=}}</ref><ref name="NicolShelton2003">{{cite journal|last1=Nicol|first1=Kathleen K.|last2=Shelton|first2=Brent J.|last3=Knovich|first3=Mary Ann|last4=Owen|first4=John|title=Overweight individuals are at increased risk for thrombotic thrombocytopenic purpura|journal=American Journal of Hematology|volume=74|issue=3|year=2003|pages=170–174|issn=0361-8609|doi=10.1002/ajh.10418}}</ref><ref name="pmid24859360">{{cite journal |vauthors=Scully M, Thomas M, Underwood M, Watson H, Langley K, Camilleri RS, Clark A, Creagh D, Rayment R, Mcdonald V, Roy A, Evans G, McGuckin S, Ni Ainle F, Maclean R, Lester W, Nash M, Scott R, O Brien P |title=Thrombotic thrombocytopenic purpura and pregnancy: presentation, management, and subsequent pregnancy outcomes |journal=Blood |volume=124 |issue=2 |pages=211–9 |date=July 2014 |pmid=24859360 |doi=10.1182/blood-2014-02-553131 |url=}}</ref>


*Black ethnicity
*Black ethnicity
*Female gender
*Female gender
*SLE
*[[SLE]]
*Obesity
*[[Obesity]]
*Pregnancy (third trimester)
*[[Pregnancy]] (third [[trimester]])
*Cancer therapies
*[[Cancer]] therapies
*[[Infection]] ([[Human Immunodeficiency Virus (HIV)|HIV]])
*[[Surgery]] ([[bone marrow]] [[stem cell transplant]])
*[[Patent medicine|Medicines]] :[[chemotherapy]], [[hormone replacement therapy]]([[Estrogen|estrogens]])


===Less Common Risk Factors===
===Less Common Risk Factors===


Less common risk factors in the development of TTP include:<ref name="pmid27383202" /><ref name="pmid20409074">{{cite journal |vauthors=Visagie GJ, Louw VJ |title=Myocardial injury in HIV-associated thrombotic thrombocytopenic purpura (TTP) |journal=Transfus Med |volume=20 |issue=4 |pages=258–64 |date=August 2010 |pmid=20409074 |doi=10.1111/j.1365-3148.2010.01006.x |url=}}</ref><ref name="pmid25483393">{{cite journal |vauthors=Jodele S, Laskin BL, Dandoy CE, Myers KC, El-Bietar J, Davies SM, Goebel J, Dixon BP |title=A new paradigm: Diagnosis and management of HSCT-associated thrombotic microangiopathy as multi-system endothelial injury |journal=Blood Rev. |volume=29 |issue=3 |pages=191–204 |date=May 2015 |pmid=25483393 |pmc=4659438 |doi=10.1016/j.blre.2014.11.001 |url=}}</ref><ref name="pmid11100281">{{cite journal |vauthors=Uderzo C, Fumagalli M, De Lorenzo P, Busca A, Vassallo E, Bonanomi S, Lanino E, Dini G, Varotto S, Messina C, Miniero R, Valsecchi MG, Balduzzi A |title=Impact of thrombotic thrombocytopenic purpura on leukemic children undergoing bone marrow transplantation |journal=Bone Marrow Transplant. |volume=26 |issue=9 |pages=1005–9 |date=November 2000 |pmid=11100281 |doi=10.1038/sj.bmt.1702648 |url=}}</ref>
Less common [[Risk factor|risk factors]] in the development of TTP include:<ref name="pmid27383202" /><ref name="pmid20409074">{{cite journal |vauthors=Visagie GJ, Louw VJ |title=Myocardial injury in HIV-associated thrombotic thrombocytopenic purpura (TTP) |journal=Transfus Med |volume=20 |issue=4 |pages=258–64 |date=August 2010 |pmid=20409074 |doi=10.1111/j.1365-3148.2010.01006.x |url=}}</ref><ref name="pmid25483393">{{cite journal |vauthors=Jodele S, Laskin BL, Dandoy CE, Myers KC, El-Bietar J, Davies SM, Goebel J, Dixon BP |title=A new paradigm: Diagnosis and management of HSCT-associated thrombotic microangiopathy as multi-system endothelial injury |journal=Blood Rev. |volume=29 |issue=3 |pages=191–204 |date=May 2015 |pmid=25483393 |pmc=4659438 |doi=10.1016/j.blre.2014.11.001 |url=}}</ref><ref name="pmid11100281">{{cite journal |vauthors=Uderzo C, Fumagalli M, De Lorenzo P, Busca A, Vassallo E, Bonanomi S, Lanino E, Dini G, Varotto S, Messina C, Miniero R, Valsecchi MG, Balduzzi A |title=Impact of thrombotic thrombocytopenic purpura on leukemic children undergoing bone marrow transplantation |journal=Bone Marrow Transplant. |volume=26 |issue=9 |pages=1005–9 |date=November 2000 |pmid=11100281 |doi=10.1038/sj.bmt.1702648 |url=}}</ref>


*HIV infection  
*[[Human Immunodeficiency Virus (HIV)|HIV infection]]
*Bone marrow transplantation
*[[Bone marrow]] [[transplantation]]
*Antiplatelet agents
*[[Antiplatelet agent|Antiplatelet agents]]
*Quinine
*[[Quinine]]


==References==
==References==

Latest revision as of 19:06, 3 October 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [2]

Overview

The most potent risk factor in the development of TTP is black ethnicity. Other risk factors include famale gender, pregnancy, obseity, chemotherapy, infection and etc.

Risk Factors

Common Risk Factors

Common risk factors in the development of TTP include:[1][2][3]

Less Common Risk Factors

Less common risk factors in the development of TTP include:[1][4][5][6]

References

  1. 1.0 1.1 Martino S, Jamme M, Deligny C, Busson M, Loiseau P, Azoulay E, Galicier L, Pène F, Provôt F, Dossier A, Saheb S, Veyradier A, Coppo P (2016). "Thrombotic Thrombocytopenic Purpura in Black People: Impact of Ethnicity on Survival and Genetic Risk Factors". PLoS ONE. 11 (7): e0156679. doi:10.1371/journal.pone.0156679. PMC 4934773. PMID 27383202.
  2. Nicol, Kathleen K.; Shelton, Brent J.; Knovich, Mary Ann; Owen, John (2003). "Overweight individuals are at increased risk for thrombotic thrombocytopenic purpura". American Journal of Hematology. 74 (3): 170–174. doi:10.1002/ajh.10418. ISSN 0361-8609.
  3. Scully M, Thomas M, Underwood M, Watson H, Langley K, Camilleri RS, Clark A, Creagh D, Rayment R, Mcdonald V, Roy A, Evans G, McGuckin S, Ni Ainle F, Maclean R, Lester W, Nash M, Scott R, O Brien P (July 2014). "Thrombotic thrombocytopenic purpura and pregnancy: presentation, management, and subsequent pregnancy outcomes". Blood. 124 (2): 211–9. doi:10.1182/blood-2014-02-553131. PMID 24859360.
  4. Visagie GJ, Louw VJ (August 2010). "Myocardial injury in HIV-associated thrombotic thrombocytopenic purpura (TTP)". Transfus Med. 20 (4): 258–64. doi:10.1111/j.1365-3148.2010.01006.x. PMID 20409074.
  5. Jodele S, Laskin BL, Dandoy CE, Myers KC, El-Bietar J, Davies SM, Goebel J, Dixon BP (May 2015). "A new paradigm: Diagnosis and management of HSCT-associated thrombotic microangiopathy as multi-system endothelial injury". Blood Rev. 29 (3): 191–204. doi:10.1016/j.blre.2014.11.001. PMC 4659438. PMID 25483393.
  6. Uderzo C, Fumagalli M, De Lorenzo P, Busca A, Vassallo E, Bonanomi S, Lanino E, Dini G, Varotto S, Messina C, Miniero R, Valsecchi MG, Balduzzi A (November 2000). "Impact of thrombotic thrombocytopenic purpura on leukemic children undergoing bone marrow transplantation". Bone Marrow Transplant. 26 (9): 1005–9. doi:10.1038/sj.bmt.1702648. PMID 11100281.

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