Thrombotic thrombocytopenic purpura natural history, complications and prognosis: Difference between revisions
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===Natural History=== | ===Natural History=== | ||
*The symptoms of (disease name) usually develop in the first/ second/ third decade of life, and start with symptoms such as | *The symptoms of (disease name) usually develop in the first/ second/ third decade of life, and start with no specificity of the signs, symptoms and laboratory findings; symptoms such as fever, renal dysfunction, neurological disorders (mild headache, onset of behavioural anomalies, transient sensory and motor deficits, coma), ischaemic gastrointestinal complications (abdominal pain) and retinal detachment.<ref name="pmid227902582">{{cite journal |vauthors=Rizzo C, Rizzo S, Scirè E, Di Bona D, Ingrassia C, Franco G, Bono R, Quintini G, Caruso C |title=Thrombotic thrombocytopenic purpura: a review of the literature in the light of our experience with plasma exchange |journal=Blood Transfus |volume=10 |issue=4 |pages=521–32 |date=October 2012 |pmid=22790258 |pmc=3496241 |doi=10.2450/2012.0122-11 |url=}}</ref> | ||
*The symptoms of | *Neurological symptoms at onset do not occur approximately more than 35% of patients. | ||
*Fever and renal dysfunction are present among only a small minority of patients. | |||
*The symptoms of TTP typically develop ___ years after exposure to ___. | |||
*If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3]. | *If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3]. | ||
===Complications=== | ===Complications=== | ||
*Common complications of TTP include:<ref name="pmid226245963">{{cite journal |vauthors=Scully M, Hunt BJ, Benjamin S, Liesner R, Rose P, Peyvandi F, Cheung B, Machin SJ |title=Guidelines on the diagnosis and management of thrombotic thrombocytopenic purpura and other thrombotic microangiopathies |journal=Br. J. Haematol. |volume=158 |issue=3 |pages=323–35 |date=August 2012 |pmid=22624596 |doi=10.1111/j.1365-2141.2012.09167.x |url=}}</ref> | *Common complications of TTP(restrict blood flow to organs such as the brain, kidneys, and heart) include:<ref name="pmid227902582" /><ref name="pmid226245963">{{cite journal |vauthors=Scully M, Hunt BJ, Benjamin S, Liesner R, Rose P, Peyvandi F, Cheung B, Machin SJ |title=Guidelines on the diagnosis and management of thrombotic thrombocytopenic purpura and other thrombotic microangiopathies |journal=Br. J. Haematol. |volume=158 |issue=3 |pages=323–35 |date=August 2012 |pmid=22624596 |doi=10.1111/j.1365-2141.2012.09167.x |url=}}</ref> | ||
**Early death in approximilaty of | **Early death in approximilaty of patients are not diagnosed | ||
** | **Neurological problems( personality changes,mild headaches, confusion and slurred speech, coma) | ||
** | **Abnormal kidney function | ||
**Heart problems | |||
===Prognosis=== | ===Prognosis=== | ||
The mortality rate is approximately 90% for untreated cases, but the prognosis is reasonably favorable (80-90%) for patients with idiopathic TTP diagnosed and treated early with [[plasmapheresis]].<ref name=" | The mortality rate is approximately 90% for untreated cases, but the prognosis is reasonably favorable (80-90%) for patients with idiopathic TTP diagnosed and treated early with [[plasmapheresis]].<ref name="pmid226245963" /> | ||
Approximately one-third of patients experiencing a TTP episode have a relapse within 10 years following their first attack | Approximately one-third of patients experiencing a TTP episode have a relapse within 10 years following their first attack. | ||
Secondary TTP still has a dismal prognosis, with mortality rates despite treatment being reported as 59% to 100%. | Secondary TTP still has a dismal prognosis, with mortality rates despite treatment being reported as 59% to 100%. | ||
Revision as of 15:56, 17 September 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [2]
Overview
If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
OR
Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].
OR
Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.
Natural History, Complications, and Prognosis
Natural History
- The symptoms of (disease name) usually develop in the first/ second/ third decade of life, and start with no specificity of the signs, symptoms and laboratory findings; symptoms such as fever, renal dysfunction, neurological disorders (mild headache, onset of behavioural anomalies, transient sensory and motor deficits, coma), ischaemic gastrointestinal complications (abdominal pain) and retinal detachment.[1]
- Neurological symptoms at onset do not occur approximately more than 35% of patients.
- Fever and renal dysfunction are present among only a small minority of patients.
- The symptoms of TTP typically develop ___ years after exposure to ___.
- If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
Complications
- Common complications of TTP(restrict blood flow to organs such as the brain, kidneys, and heart) include:[1][2]
- Early death in approximilaty of patients are not diagnosed
- Neurological problems( personality changes,mild headaches, confusion and slurred speech, coma)
- Abnormal kidney function
- Heart problems
Prognosis
The mortality rate is approximately 90% for untreated cases, but the prognosis is reasonably favorable (80-90%) for patients with idiopathic TTP diagnosed and treated early with plasmapheresis.[2]
Approximately one-third of patients experiencing a TTP episode have a relapse within 10 years following their first attack.
Secondary TTP still has a dismal prognosis, with mortality rates despite treatment being reported as 59% to 100%.
References
- ↑ 1.0 1.1 Rizzo C, Rizzo S, Scirè E, Di Bona D, Ingrassia C, Franco G, Bono R, Quintini G, Caruso C (October 2012). "Thrombotic thrombocytopenic purpura: a review of the literature in the light of our experience with plasma exchange". Blood Transfus. 10 (4): 521–32. doi:10.2450/2012.0122-11. PMC 3496241. PMID 22790258.
- ↑ 2.0 2.1 Scully M, Hunt BJ, Benjamin S, Liesner R, Rose P, Peyvandi F, Cheung B, Machin SJ (August 2012). "Guidelines on the diagnosis and management of thrombotic thrombocytopenic purpura and other thrombotic microangiopathies". Br. J. Haematol. 158 (3): 323–35. doi:10.1111/j.1365-2141.2012.09167.x. PMID 22624596.