Thrombotic thrombocytopenic purpura differential diagnosis: Difference between revisions

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{{Thrombotic thrombocytopenic purpura}}
[[Image:Home_logo1.png|right|250px|link=http://www.wikidoc.org/index.php/Thrombotic_thrombocytopenic_purpura]]
{{CMG}}
{{CMG}} {{AE}} {{S.G.}}
==Overview==
==Overview==
The main differential [[diagnosis]] of TTP is [[hemolytic-uremic syndrome]]. TTP should be diffrential from the other [[Disease|disaeses]] such as [[TMA]] [[Syndrome|syndromes]], disseminated [[intravascular]] [[coagulation]] [[Hypertension|,hypertension]], [[Idiopathic thrombocytopenic purpura|immune thrombocytopenic purpura]] ([[Idiopathic thrombocytopenic purpura|ITP]])
* [[Malignant hypertension]]
* [[Hematological]] [[abnormalities]]
* [[Ischemic]] manifestations linked to [[Autoimmune disease|autoimmune diseases]]
== Differential Diagnosis ==
== Differential Diagnosis ==
The differential diagnosis of TTP includes [[hemolytic-uremic syndrome]] (HUS; which has neurosymptoms, renal failure, hypertension and fever).  Note that ADAMTS13 activity is normal in HUS.
The main differential [[diagnosis]] of TTP is [[hemolytic-uremic syndrome]] ([[Hemolytic-uremic syndrome|HUS]], which has neurosymptoms, [[renal failure]], [[hypertension]] and [[fever]]).  Note that [[ADAMTS13]] [[Activity (chemistry)|activity]] is [[normal]] in [[Hemolytic-uremic syndrome|HUS]].<ref name="JolyCoppo2017">{{cite journal|last1=Joly|first1=Bérangère S.|last2=Coppo|first2=Paul|last3=Veyradier|first3=Agnès|title=Thrombotic thrombocytopenic purpura|journal=Blood|volume=129|issue=21|year=2017|pages=2836–2846|issn=0006-4971|doi=10.1182/blood-2016-10-709857}}</ref>
[Disease name] must be differentiated from [differential dx1], [differential dx2], and [differential dx3].


OR
TTP must be differentiated from


As [disease name] manifests in a variety of clinical forms, differentiation must be established in accordance with the particular subtype. [Subtype name 1] must be differentiated from other diseases that cause [clinical feature 1], such as [differential dx1] and [differential dx2]. In contrast, [subtype name 2] must be differentiated from other diseases that cause [clinical feature 2], such as [differential dx3] and [differential dx4].
* [[TMA]] [[Syndrome|syndromes]]
* Disseminated [[intravascular]] [[coagulation]]
* [[Hypertension]]
* [[Idiopathic thrombocytopenic purpura|Immune hrombocytopenic purpura]] ([[Idiopathic thrombocytopenic purpura|ITP]])
* [[Malignant hypertension]]
* [[Hematological]] [[abnormalities]]
* [[Ischemic]] manifestations linked to [[Autoimmune disease|autoimmune diseases]]


===Differentiating [disease name] from other diseases on the basis of [symptom 1], [symptom 2], and [symptom 3]===
===Differentiating TTP from other diseases on the basis of Symptoms:===


On the basis [symptom 1], [symptom 2], and [symptom 3], [disease name] must be differentiated from [disease 1], [disease 2], [disease 3], [disease 4], [disease 5], and [disease 6].
*On the basis [[thrombocytopenia]], MAHA, fluctuating [[neurological]] [[Medical sign|signs]], [[renal]] faluer and [[fever]], TTP must be differentiated from<ref name="KarpmanLoos2017">{{cite journal|last1=Karpman|first1=Diana|last2=Loos|first2=Sebastian|last3=Tati|first3=Ramesh|last4=Arvidsson|first4=Ida|title=Haemolytic uraemic syndrome|journal=Journal of Internal Medicine|volume=281|issue=2|year=2017|pages=123–148|issn=09546820|doi=10.1111/joim.12546}}</ref>
**[[Autoimmune]] [[Hemolysis|haemolysis]]
**[[Evans syndrome]] disseminated [[intravascular]] [[coagulation]] [[pregnancy]]-associated such as:
***[[HELLP syndrome|HELLP]] ([[Hemolysis|haemolysis]]
***Elevated [[liver]] [[enzymes]] and low [[platelets]])
***[[eclampsia]]
**[[Hemolytic-uremic syndrome|Haemolytic uraemic syndrome]]
**[[Drugs]]:
***[[Quinine]]
***[[simvastatin]]
***[[interferon]]
***[[Calcineurin]] [[Inhibitor|inhibitors]]
**[[Malignant]] [[hypertension]]
**[[Infection|Infections]] (typically [[viral]] ([[cytomegalovirus]], [[adenovirus]], [[herpes simplex]] [[Virus (biology)|virus]])
**Severe [[bacterial]] ([[meningococcus]], [[pneumococcus]])
**[[Fungal]] [[autoimmune]] [[disease]] ([[lupus nephritis]], [[Acute (medicine)|acute]] [[scleroderma]])
**[[Vasculitis]] [[Hemolytic-uremic syndrome|haemolytic uraemic syndrome]] ([[Diarrhea|diarrhoea]] positive/negative)
**[[Malignancy]] [[catastrophic antiphospholipid syndrome]]
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Latest revision as of 15:09, 6 March 2019


Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [2]

Overview

The main differential diagnosis of TTP is hemolytic-uremic syndrome. TTP should be diffrential from the other disaeses such as TMA syndromes, disseminated intravascular coagulation ,hypertension, immune thrombocytopenic purpura (ITP)

Differential Diagnosis

The main differential diagnosis of TTP is hemolytic-uremic syndrome (HUS, which has neurosymptoms, renal failure, hypertension and fever). Note that ADAMTS13 activity is normal in HUS.[1]

TTP must be differentiated from

Differentiating TTP from other diseases on the basis of Symptoms:

References

  1. ↑ Joly, Bérangère S.; Coppo, Paul; Veyradier, Agnès (2017). "Thrombotic thrombocytopenic purpura". Blood. 129 (21): 2836–2846. doi:10.1182/blood-2016-10-709857. ISSN 0006-4971.
  2. ↑ Karpman, Diana; Loos, Sebastian; Tati, Ramesh; Arvidsson, Ida (2017). "Haemolytic uraemic syndrome". Journal of Internal Medicine. 281 (2): 123–148. doi:10.1111/joim.12546. ISSN 0954-6820.

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