Thiamine pyrophosphate
| Thiamine pyrophosphate | |
|---|---|
| |
| IUPAC name | 2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethyl phosphono hydrogen phosphate |
| Other names | Thiamine diphosphate |
| Identifiers | |
| CAS number | |
| PubChem | |
| MeSH | |
| SMILES | [n+]1(c(c(CCO[P@@](OP(O)(O)=O)(O)=O)sc1)C)Cc1c(nc(C)nc1)N.[ClH-] |
| Properties | |
| Molecular formula | C12H19N4O7P2S+ |
| Molar mass | 425.316 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references | |
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Thiamine pyrophosphate (TPP) or thiamine diphosphate (ThDP) is a thiamine derivative which is cleaved by thiamine pyrophosphatase. Thiamine phyrophosphate is the active form of thiamine (vitamin B1).[1]
ThDP is a prosthetic group in many enzymes, such as:
- Pyruvate dehydrogenase complex
- Alpha-ketoglutarate dehydrogenase complex
- Branched-chain amino acid dehydrogenase complex
- 2-hydroxyphytanoyl-CoA lyase
- Transketolase
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| Evidence Based Medicine Regarding Thiamine pyrophosphate | AND (Cochrane Database Syst Rev[http://worldselectshop.com/?id=9361 Cochrane Collaboration on Thiamine pyrophosphate • Bandolier on Thiamine pyrophosphate • TRIP on Thiamine pyrophosphate |
| Cost Effectiveness of Thiamine pyrophosphate | AND (Cost effectiveness) |
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AND (Dose)}} Dosing of Thiamine pyrophosphate • AND (drug interactions)}} Drug interactions with Thiamine pyrophosphate • AND (side effects)}} Side effects of Thiamine pyrophosphate • AND (Allergy)}} Allergic reactions to Thiamine pyrophosphate • AND (overdose)}} Overdose information on Thiamine pyrophosphate • AND (carcinogenicity)}} Carcinogenicity information on Thiamine pyrophosphate • AND (pregnancy)}} Thiamine pyrophosphate in pregnancy • AND (pharmacokinetics)}} Pharmacokinetics of Thiamine pyrophosphate •
| group9 = Genetics, Pharmacogenomics, and Proteinomics of Thiamine pyrophosphate
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AND (pharmacogenomics)}} Genetics of Thiamine pyrophosphate • AND (pharmacogenomics)}} Pharmacogenomics of Thiamine pyrophosphate • AND (proteomics)}} Proteomics of Thiamine pyrophosphate
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