Teratoma pathophysiology: Difference between revisions
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==Pathophysiology== | ==Pathophysiology== | ||
{{familytree/start |summary=Sample 1}} | |||
{{familytree | | | | | | | | A01 |A01=[[Germ cell]]}} | |||
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{{familytree | | | B01 | | | | | | | | B02 | | |B01=[[Pathogenesis]]|B02=[[Malignant transformation]]}} | |||
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{{familytree | | | C01 | | | | | | | | |!| |C01=[[Mature teratoma]]}} | |||
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{{familytree | | | | | | | | | | E02 | | |E02=[[Tumors]] with primitive [[embryonic]] [[ectoderm]], [[mesoderm]], and/or [[endoderm]] differentiation| }} | |||
{{familytree | | | | | | | | | |!| | | |!| | | |!| | }} | |||
{{familytree | | | | | | | | | | | F02 | | | |=|F02=Immature [[teratoma]]}} | |||
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===Pathogenesis=== | ===Pathogenesis=== | ||
*Mature teratoma arises from a pathological transformation of primordial germ cell during the develompment.<ref name="VuralVural2015">{{cite journal|last1=Vural|first1=F.|last2=Vural|first2=B.|last3=Paksoy|first3=N.|title=Vaginal teratoma: A case report and review of the literature|journal=Journal of Obstetrics and Gynaecology|volume=35|issue=7|year=2015|pages=757–758|issn=0144-3615|doi=10.3109/01443615.2015.1004525}}</ref><ref name="El-MaarriRijlaarsdam2015">{{cite journal|last1=El-Maarri|first1=Osman|last2=Rijlaarsdam|first2=Martin A.|last3=Tax|first3=David M. J.|last4=Gillis|first4=Ad J. M.|last5=Dorssers|first5=Lambert C. J.|last6=Koestler|first6=Devin C.|last7=de Ridder|first7=Jeroen|last8=Looijenga|first8=Leendert H. J.|title=Genome Wide DNA Methylation Profiles Provide Clues to the Origin and Pathogenesis of Germ Cell Tumors|journal=PLOS ONE|volume=10|issue=4|year=2015|pages=e0122146|issn=1932-6203|doi=10.1371/journal.pone.0122146}}</ref> | *Mature teratoma arises from a pathological transformation of primordial germ cell during the develompment.<ref name="VuralVural2015">{{cite journal|last1=Vural|first1=F.|last2=Vural|first2=B.|last3=Paksoy|first3=N.|title=Vaginal teratoma: A case report and review of the literature|journal=Journal of Obstetrics and Gynaecology|volume=35|issue=7|year=2015|pages=757–758|issn=0144-3615|doi=10.3109/01443615.2015.1004525}}</ref><ref name="El-MaarriRijlaarsdam2015">{{cite journal|last1=El-Maarri|first1=Osman|last2=Rijlaarsdam|first2=Martin A.|last3=Tax|first3=David M. J.|last4=Gillis|first4=Ad J. M.|last5=Dorssers|first5=Lambert C. J.|last6=Koestler|first6=Devin C.|last7=de Ridder|first7=Jeroen|last8=Looijenga|first8=Leendert H. J.|title=Genome Wide DNA Methylation Profiles Provide Clues to the Origin and Pathogenesis of Germ Cell Tumors|journal=PLOS ONE|volume=10|issue=4|year=2015|pages=e0122146|issn=1932-6203|doi=10.1371/journal.pone.0122146}}</ref> | ||
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*Mature teratoma contains a well differentiated tumor with all three germ layers (ectoderm, mesoderm and endoderm).<ref name="El-MaarriRijlaarsdam2015">{{cite journal|last1=El-Maarri|first1=Osman|last2=Rijlaarsdam|first2=Martin A.|last3=Tax|first3=David M. J.|last4=Gillis|first4=Ad J. M.|last5=Dorssers|first5=Lambert C. J.|last6=Koestler|first6=Devin C.|last7=de Ridder|first7=Jeroen|last8=Looijenga|first8=Leendert H. J.|title=Genome Wide DNA Methylation Profiles Provide Clues to the Origin and Pathogenesis of Germ Cell Tumors|journal=PLOS ONE|volume=10|issue=4|year=2015|pages=e0122146|issn=1932-6203|doi=10.1371/journal.pone.0122146}}</ref> | *Mature teratoma contains a well differentiated tumor with all three germ layers (ectoderm, mesoderm and endoderm).<ref name="El-MaarriRijlaarsdam2015">{{cite journal|last1=El-Maarri|first1=Osman|last2=Rijlaarsdam|first2=Martin A.|last3=Tax|first3=David M. J.|last4=Gillis|first4=Ad J. M.|last5=Dorssers|first5=Lambert C. J.|last6=Koestler|first6=Devin C.|last7=de Ridder|first7=Jeroen|last8=Looijenga|first8=Leendert H. J.|title=Genome Wide DNA Methylation Profiles Provide Clues to the Origin and Pathogenesis of Germ Cell Tumors|journal=PLOS ONE|volume=10|issue=4|year=2015|pages=e0122146|issn=1932-6203|doi=10.1371/journal.pone.0122146}}</ref> | ||
*Mature teratoma may be located in the embryonic fusion midline or paraxial, mediastinum, ovary, retroperitoneum, and sacrococcygeal.<ref name="pmid8008317">{{cite journal| author=Comerci JT, Licciardi F, Bergh PA, Gregori C, Breen JL| title=Mature cystic teratoma: a clinicopathologic evaluation of 517 cases and review of the literature. | journal=Obstet Gynecol | year= 1994 | volume= 84 | issue= 1 | pages= 22-8 | pmid=8008317 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8008317 }} </ref> | *Mature teratoma may be located in the embryonic fusion midline or paraxial, mediastinum, ovary, retroperitoneum, and sacrococcygeal.<ref name="pmid8008317">{{cite journal| author=Comerci JT, Licciardi F, Bergh PA, Gregori C, Breen JL| title=Mature cystic teratoma: a clinicopathologic evaluation of 517 cases and review of the literature. | journal=Obstet Gynecol | year= 1994 | volume= 84 | issue= 1 | pages= 22-8 | pmid=8008317 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8008317 }} </ref> | ||
*Immature teratoma my be due to the malignant tranformation of germ cell with primitive | |||
Revision as of 20:41, 28 October 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Gertrude Djouka, M.D.[2]
Overview
The histopathology of teratoma depends on the histological subtype.Teratoma is a germ cell tumor due to abnormal development of pluripotent cells.
Pathophysiology
Germ cell | |||||||||||||||||||||||||||||||||||||||
Pathogenesis | Malignant transformation | ||||||||||||||||||||||||||||||||||||||
Mature teratoma | |||||||||||||||||||||||||||||||||||||||
{{{ }}} | Tumors with primitive embryonic ectoderm, mesoderm, and/or endoderm differentiation | {{{ }}} | |||||||||||||||||||||||||||||||||||||
Immature teratoma | |||||||||||||||||||||||||||||||||||||||
Pathogenesis
- Mature teratoma arises from a pathological transformation of primordial germ cell during the develompment.[1][2]
- Mature teratoma comes from a single germ cell tumor after first phase of meiosis.[3]
- Mature teratoma contains a well differentiated tumor with all three germ layers (ectoderm, mesoderm and endoderm).[2]
- Mature teratoma may be located in the embryonic fusion midline or paraxial, mediastinum, ovary, retroperitoneum, and sacrococcygeal.[4]
- Immature teratoma my be due to the malignant tranformation of germ cell with primitive
References
- ↑ Vural, F.; Vural, B.; Paksoy, N. (2015). "Vaginal teratoma: A case report and review of the literature". Journal of Obstetrics and Gynaecology. 35 (7): 757–758. doi:10.3109/01443615.2015.1004525. ISSN 0144-3615.
- ↑ 2.0 2.1 El-Maarri, Osman; Rijlaarsdam, Martin A.; Tax, David M. J.; Gillis, Ad J. M.; Dorssers, Lambert C. J.; Koestler, Devin C.; de Ridder, Jeroen; Looijenga, Leendert H. J. (2015). "Genome Wide DNA Methylation Profiles Provide Clues to the Origin and Pathogenesis of Germ Cell Tumors". PLOS ONE. 10 (4): e0122146. doi:10.1371/journal.pone.0122146. ISSN 1932-6203.
- ↑ Linder, David; McCaw, Barbara Kaiser; Hecht, Frederick (1975). "Parthenogenic Origin of Benign Ovarian Teratomas". New England Journal of Medicine. 292 (2): 63–66. doi:10.1056/NEJM197501092920202. ISSN 0028-4793.
- ↑ Comerci JT, Licciardi F, Bergh PA, Gregori C, Breen JL (1994). "Mature cystic teratoma: a clinicopathologic evaluation of 517 cases and review of the literature". Obstet Gynecol. 84 (1): 22–8. PMID 8008317.