TNNI2

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Troponin I type 2 (skeletal, fast)
File:PBB Protein TNNI2 image.jpg
PDB rendering based on 1a2x.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Identifiers
Symbols TNNI2 ; AMCD2B; DA2B; FSSV
External IDs Template:OMIM5 Template:MGI HomoloGene37752
RNA expression pattern
File:PBB GE TNNI2 206393 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Troponin I type 2 (skeletal, fast), also known as TNNI2, is a human gene.[1]


References

  1. "Entrez Gene: TNNI2 troponin I type 2 (skeletal, fast)".

Further reading

  • Kinoshita S, Adachi W, Sotozono C; et al. (2001). "Characteristics of the human ocular surface epithelium". Progress in retinal and eye research. 20 (5): 639–73. PMID 11470454.
  • Wade R, Eddy R, Shows TB, Kedes L (1990). "cDNA sequence, tissue-specific expression, and chromosomal mapping of the human slow-twitch skeletal muscle isoform of troponin I.". Genomics. 7 (3): 346–57. PMID 2365354.
  • Huang TS, Bylund DB, Stull JT, Krebs EG (1974). "The amino acid sequences of the phosphorylated sites in troponin-I from rabbit skeletal muscle". FEBS Lett. 42 (3): 249–52. PMID 4369265.
  • Moir AJ, Ordidge M, Grand RJ; et al. (1983). "Studies of the interaction of troponin I with proteins of the I-filament and calmodulin". Biochem. J. 209 (2): 417–26. PMID 6847627.
  • Grand RJ, Levine BA, Perry SV (1982). "Proton-magnetic-resonance studies on the interaction of rabbit skeletal-muscle troponin I with troponin C and actin". Biochem. J. 203 (1): 61–8. PMID 7103951.
  • Chong PC, Hodges RS (1982). "Photochemical cross-linking between rabbit skeletal troponin subunits. Troponin I-troponin T interactions". J. Biol. Chem. 257 (19): 11667–72. PMID 7118902.
  • Zhu L, Perez-Alvarado G, Wade R (1994). "Sequencing of a cDNA encoding the human fast-twitch skeletal muscle isoform of troponin I.". Biochim. Biophys. Acta. 1217 (3): 338–40. PMID 8148383.
  • Lanfranchi G, Muraro T, Caldara F; et al. (1996). "Identification of 4370 expressed sequence tags from a 3'-end-specific cDNA library of human skeletal muscle by DNA sequencing and filter hybridization". Genome Res. 6 (1): 35–42. PMID 8681137.
  • Jha PK, Leavis PC, Sarkar S (1997). "Interaction of deletion mutants of troponins I and T: COOH-terminal truncation of troponin T abolishes troponin I binding and reduces Ca2+ sensitivity of the reconstituted regulatory system". Biochemistry. 35 (51): 16573–80. doi:10.1021/bi9622433. PMID 8987992.
  • Tiso N, Rampoldi L, Pallavicini A; et al. (1997). "Fine mapping of five human skeletal muscle genes: alpha-tropomyosin, beta-tropomyosin, troponin-I slow-twitch, troponin-I fast-twitch, and troponin-C fast". Biochem. Biophys. Res. Commun. 230 (2): 347–50. doi:10.1006/bbrc.1996.5958. PMID 9016781.
  • Stefancsik R, Jha PK, Sarkar S (1998). "Identification and mutagenesis of a highly conserved domain in troponin T responsible for troponin I binding: potential role for coiled coil interaction". Proc. Natl. Acad. Sci. U.S.A. 95 (3): 957–62. PMID 9448267.
  • Vassylyev DG, Takeda S, Wakatsuki S; et al. (1998). "Crystal structure of troponin C in complex with troponin I fragment at 2.3-A resolution". Proc. Natl. Acad. Sci. U.S.A. 95 (9): 4847–52. PMID 9560191.
  • Jha PK, Sarkar S (1998). "A recombinant monocysteine mutant (Ser to Cys-155) of fast skeletal troponin T: identification by cross-linking of a domain involved in a physiologically relevant interaction with troponins C and I.". Biochemistry. 37 (35): 12253–60. doi:10.1021/bi980025z. PMID 9724539.
  • Moses MA, Wiederschain D, Wu I; et al. (1999). "Troponin I is present in human cartilage and inhibits angiogenesis". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 2645–50. PMID 10077564.
  • Mullen AJ, Barton PJ (2000). "Structural characterization of the human fast skeletal muscle troponin I gene (TNNI2)". Gene. 242 (1–2): 313–20. PMID 10721725.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Sung SS, Brassington AM, Grannatt K; et al. (2003). "Mutations in genes encoding fast-twitch contractile proteins cause distal arthrogryposis syndromes". Am. J. Hum. Genet. 72 (3): 681–90. PMID 12592607.
  • Li Q, Liu Y, Shen PY; et al. (2003). "Troponin I binds polycystin-L and inhibits its calcium-induced channel activation". Biochemistry. 42 (24): 7618–25. doi:10.1021/bi034210a. PMID 12809519.
  • Thijssen VL, Ausma J, Gorza L; et al. (2005). "Troponin I isoform expression in human and experimental atrial fibrillation". Circulation. 110 (7): 770–5. doi:10.1161/01.CIR.0000138849.03311.C6. PMID 15289369.

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