TLX1

T-cell leukemia homeobox 1
Identifiers
Symbols	TLX1 ; HOX11; MGC163402; TCL3
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4031
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE TLX1 207179 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

T-cell leukemia homeobox 1, also known as TLX1, is a human gene.

Further reading

• Allen TD, Zhu YX, Hawley TS, Hawley RG (2001). "TALE homeoproteins as HOX11-interacting partners in T-cell leukemia". Leuk. Lymphoma. 39 (3–4): 241–56. PMID 11342305.CS1 maint: Multiple names: authors list (link)
• Lu M, Zhang N, Ho AD (1992). "Genomic organization of the putative human homeobox proto-oncogene HOX-11 (TCL-3) and its endogenous expression in T cells". Oncogene. 7 (7): 1325–30. PMID 1352396.CS1 maint: Multiple names: authors list (link)
• Hatano M, Roberts CW, Minden M; et al. (1991). "Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia". Science. 253 (5015): 79–82. PMID 1676542.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kennedy MA, Gonzalez-Sarmiento R, Kees UR; et al. (1991). "HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24". Proc. Natl. Acad. Sci. U.S.A. 88 (20): 8900–4. PMID 1681546.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lu M, Gong ZY, Shen WF, Ho AD (1991). "The tcl-3 proto-oncogene altered by chromosomal translocation in T-cell leukemia codes for a homeobox protein". EMBO J. 10 (10): 2905–10. PMID 1717256.CS1 maint: Multiple names: authors list (link)
• McAlpine PJ, Shows TB (1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. PMID 1973146.
• Dear TN, Colledge WH, Carlton MB; et al. (1995). "The Hox11 gene is essential for cell survival during spleen development". Development. 121 (9): 2909–15. PMID 7555717.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dear TN, Sanchez-Garcia I, Rabbitts TH (1993). "The HOX11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes". Proc. Natl. Acad. Sci. U.S.A. 90 (10): 4431–5. PMID 8099440.CS1 maint: Multiple names: authors list (link)
• Kawabe T, Muslin AJ, Korsmeyer SJ (1997). "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint". Nature. 385 (6615): 454–8. doi:10.1038/385454a0. PMID 9009195.CS1 maint: Multiple names: authors list (link)
• Brake RL, Kees UR, Watt PM (1998). "Multiple negative elements contribute to repression of the HOX11 proto-oncogene". Oncogene. 17 (14): 1787–95. doi:10.1038/sj.onc.1202078. PMID 9778044.CS1 maint: Multiple names: authors list (link)
• Zhang N, Shen W, Hawley RG, Lu M (1999). "HOX11 interacts with CTF1 and mediates hematopoietic precursor cell immortalization". Oncogene. 18 (13): 2273–9. doi:10.1038/sj.onc.1202545. PMID 10327073.CS1 maint: Multiple names: authors list (link)
• Watt PM, Ranford PR, Kees UR (1999). "Sequence of 10q24 locus surrounding the HOX11 oncogene reveals a new gene HUG1 expressed in a T-ALL cell line". Gene. 234 (1): 169–76. PMID 10393251.CS1 maint: Multiple names: authors list (link)
• Brake RL, Kees UR, Watt PM (2002). "A complex containing PBX2 contributes to activation of the proto-oncogene HOX11". Biochem. Biophys. Res. Commun. 294 (1): 23–34. doi:10.1016/S0006-291X(02)00426-6. PMID 12054735.CS1 maint: Multiple names: authors list (link)
• Bodenmiller DM, Baxter CS, Hansen DV, Potter SS (2003). "Phylogenetic analysis of Hoxa 11 sequences reveals absence of transposable elements, conservation of transcription factor binding sites, and suggests antisense coding function". DNA Seq. 13 (2): 77–83. PMID 12180349.CS1 maint: Multiple names: authors list (link)
• Cavé H, Suciu S, Preudhomme C; et al. (2004). "Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951". Blood. 103 (2): 442–50. doi:10.1182/blood-2003-05-1495. PMID 14504110.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hoffmann K, Dixon DN, Greene WK; et al. (2005). "A microarray model system identifies potential new target genes of the proto-oncogene HOX11". Genes Chromosomes Cancer. 41 (4): 309–20. doi:10.1002/gcc.20104. PMID 15384172.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Riz I, Hawley RG (2005). "G1/S transcriptional networks modulated by the HOX11/TLX1 oncogene of T-cell acute lymphoblastic leukemia". Oncogene. 24 (36): 5561–75. doi:10.1038/sj.onc.1208727. PMID 15897879.
• Heidari M, Rice KL, Phillips JK; et al. (2006). "The nuclear oncoprotein TLX1/HOX11 associates with pericentromeric satellite 2 DNA in leukemic T-cells". Leukemia. 20 (2): 304–12. doi:10.1038/sj.leu.2404071. PMID 16357834.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen E, Lim MS, Rosic-Kablar S; et al. (2006). "Dysregulated expression of mitotic regulators is associated with B-cell lymphomagenesis in HOX11-transgenic mice". Oncogene. 25 (18): 2575–87. doi:10.1038/sj.onc.1209285. PMID 16407851.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)