TADA2L

Transcriptional adaptor 2 (ADA2 homolog, yeast)-like
File:PBB Protein TADA2L image.jpg PDB rendering based on 1x41.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1x41​, 2aqe​, 2aqf​, 2cuj​
Identifiers
Symbols	TADA2L ; ADA2; FLJ12705; KL04P; hADA2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 38834
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE TADA2L 209938 at tn.png
File:PBB GE TADA2L 210537 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Transcriptional adaptor 2 (ADA2 homolog, yeast)-like, also known as TADA2L, is a human gene.

Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Two transcript variants encoding different isoforms have been identified for this gene.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Candau R, Moore PA, Wang L; et al. (1996). "Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5". Mol. Cell. Biol. 16 (2): 593–602. PMID 8552087.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang L, Mizzen C, Ying C; et al. (1997). "Histone acetyltransferase activity is conserved between yeast and human GCN5 and is required for complementation of growth and transcriptional activation". Mol. Cell. Biol. 17 (1): 519–27. PMID 8972232.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Carter KC, Wang L, Shell BK; et al. (1997). "The human transcriptional adaptor genes TADA2L and GCN5L2 colocalize to chromosome 17q12-q21 and display a similar tissue expression pattern". Genomics. 40 (3): 497–500. doi:10.1006/geno.1996.4605. PMID 9073520.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Henriksson A, Almlöf T, Ford J; et al. (1997). "Role of the Ada adaptor complex in gene activation by the glucocorticoid receptor". Mol. Cell. Biol. 17 (6): 3065–73. PMID 9154805.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ogryzko VV, Kotani T, Zhang X; et al. (1998). "Histone-like TAFs within the PCAF histone acetylase complex". Cell. 94 (1): 35–44. PMID 9674425.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vassilev A, Yamauchi J, Kotani T; et al. (1999). "The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily". Mol. Cell. 2 (6): 869–75. PMID 9885574.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang T, Kobayashi T, Takimoto R; et al. (2002). "hADA3 is required for p53 activity". EMBO J. 20 (22): 6404–13. doi:10.1093/emboj/20.22.6404. PMID 11707411.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Barlev NA, Emelyanov AV, Castagnino P; et al. (2003). "A novel human Ada2 homologue functions with Gcn5 or Brg1 to coactivate transcription". Mol. Cell. Biol. 23 (19): 6944–57. PMID 12972612.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Qian C, Zhang Q, Li S; et al. (2006). "Structure and chromosomal DNA binding of the SWIRM domain". Nat. Struct. Mol. Biol. 12 (12): 1078–85. doi:10.1038/nsmb1022. PMID 16299514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)