TADA2L: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Transcriptional adapter 2-alpha''' is a [[protein]] that in humans is encoded by the ''TADA2A'' [[gene]].<ref name="pmid8552087">{{cite journal | vauthors = Candau R, Moore PA, Wang L, Barlev N, Ying CY, Rosen CA, Berger SL | title = Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5 | journal = Molecular and Cellular Biology | volume = 16 | issue = 2 | pages = 593–602 | date = Feb 1996 | pmid = 8552087 | pmc = 231038 | doi = 10.1128/mcb.16.2.593}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TADA2L transcriptional adaptor 2 (ADA2 homolog, yeast)-like| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6871| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_TADA2L_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1x41.
| PDB = {{PDB2|1x41}}, {{PDB2|2aqe}}, {{PDB2|2aqf}}, {{PDB2|2cuj}}
| Name = Transcriptional adaptor 2 (ADA2 homolog, yeast)-like
| HGNCid = 11531
| Symbol = TADA2L
| AltSymbols =; ADA2; FLJ12705; KL04P; hADA2
| OMIM = 602276
| ECnumber = 
| Homologene = 38834
| MGIid = 2144471
| GeneAtlas_image1 = PBB_GE_TADA2L_209938_at_tn.png
| GeneAtlas_image2 = PBB_GE_TADA2L_210537_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003712 |text = transcription cofactor activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005681 |text = spliceosome}} {{GNF_GO|id=GO:0005694 |text = chromosome}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006397 |text = mRNA processing}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}} {{GNF_GO|id=GO:0045449 |text = regulation of transcription}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6871
    | Hs_Ensembl = ENSG00000108264
    | Hs_RefseqProtein = NP_001479
    | Hs_RefseqmRNA = NM_001488
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 32841425
    | Hs_GenLoc_end = 32911337
    | Hs_Uniprot = O75478
    | Mm_EntrezGene = 217031
    | Mm_Ensembl = ENSMUSG00000018651
    | Mm_RefseqmRNA = NM_172562
    | Mm_RefseqProtein = NP_766150
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 83895115
    | Mm_GenLoc_end = 83943292
    | Mm_Uniprot = Q3UQN9
  }}
}}
'''Transcriptional adaptor 2 (ADA2 homolog, yeast)-like''', also known as '''TADA2L''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TADA2L transcriptional adaptor 2 (ADA2 homolog, yeast)-like| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6871| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Two transcript variants encoding different isoforms have been identified for this gene.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Two transcript variants encoding different isoforms have been identified for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: TADA2L transcriptional adaptor 2 (ADA2 homolog, yeast)-like| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6871| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | author=Candau R, Moore PA, Wang L, ''et al.'' |title=Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5. |journal=Mol. Cell. Biol. |volume=16 |issue= 2 |pages= 593-602 |year= 1996 |pmid= 8552087 |doi=  }}
*{{cite journal  | author=Wang L, Mizzen C, Ying C, ''et al.'' |title=Histone acetyltransferase activity is conserved between yeast and human GCN5 and is required for complementation of growth and transcriptional activation. |journal=Mol. Cell. Biol. |volume=17 |issue= 1 |pages= 519-27 |year= 1997 |pmid= 8972232 |doi=  }}
*{{cite journal  | author=Carter KC, Wang L, Shell BK, ''et al.'' |title=The human transcriptional adaptor genes TADA2L and GCN5L2 colocalize to chromosome 17q12-q21 and display a similar tissue expression pattern. |journal=Genomics |volume=40 |issue= 3 |pages= 497-500 |year= 1997 |pmid= 9073520 |doi= 10.1006/geno.1996.4605 }}
*{{cite journal  | author=Henriksson A, Almlöf T, Ford J, ''et al.'' |title=Role of the Ada adaptor complex in gene activation by the glucocorticoid receptor. |journal=Mol. Cell. Biol. |volume=17 |issue= 6 |pages= 3065-73 |year= 1997 |pmid= 9154805 |doi=  }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  | author=Ogryzko VV, Kotani T, Zhang X, ''et al.'' |title=Histone-like TAFs within the PCAF histone acetylase complex. |journal=Cell |volume=94 |issue= 1 |pages= 35-44 |year= 1998 |pmid= 9674425 |doi=  }}
*{{cite journal  | author=Vassilev A, Yamauchi J, Kotani T, ''et al.'' |title=The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily. |journal=Mol. Cell |volume=2 |issue= 6 |pages= 869-75 |year= 1999 |pmid= 9885574 |doi=  }}
*{{cite journal  | author=Wang T, Kobayashi T, Takimoto R, ''et al.'' |title=hADA3 is required for p53 activity. |journal=EMBO J. |volume=20 |issue= 22 |pages= 6404-13 |year= 2002 |pmid= 11707411 |doi= 10.1093/emboj/20.22.6404 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Barlev NA, Emelyanov AV, Castagnino P, ''et al.'' |title=A novel human Ada2 homologue functions with Gcn5 or Brg1 to coactivate transcription. |journal=Mol. Cell. Biol. |volume=23 |issue= 19 |pages= 6944-57 |year= 2003 |pmid= 12972612 |doi=  }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Qian C, Zhang Q, Li S, ''et al.'' |title=Structure and chromosomal DNA binding of the SWIRM domain. |journal=Nat. Struct. Mol. Biol. |volume=12 |issue= 12 |pages= 1078-85 |year= 2006 |pmid= 16299514 |doi= 10.1038/nsmb1022 }}
}}
{{refend}}


{{protein-stub}}
TADA2L has been shown to [[Protein-protein interaction|interact]] with [[GCN5L2]],<ref name=pmid9488450>{{cite journal | vauthors = Barlev NA, Poltoratsky V, Owen-Hughes T, Ying C, Liu L, Workman JL, Berger SL | title = Repression of GCN5 histone acetyltransferase activity via bromodomain-mediated binding and phosphorylation by the Ku-DNA-dependent protein kinase complex | journal = Molecular and Cellular Biology | volume = 18 | issue = 3 | pages = 1349–58 | date = Mar 1998 | pmid = 9488450 | pmc = 108848 | doi=10.1128/mcb.18.3.1349}}</ref><ref name=pmid8972232>{{cite journal | vauthors = Wang L, Mizzen C, Ying C, Candau R, Barlev N, Brownell J, Allis CD, Berger SL | title = Histone acetyltransferase activity is conserved between yeast and human GCN5 and is required for complementation of growth and transcriptional activation | journal = Molecular and Cellular Biology | volume = 17 | issue = 1 | pages = 519–27 | date = Jan 1997 | pmid = 8972232 | pmc = 231776 | doi=10.1128/mcb.17.1.519}}</ref> [[TADA3L]]<ref name=pmid16189514>{{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref><ref name=pmid11707411>{{cite journal | vauthors = Wang T, Kobayashi T, Takimoto R, Denes AE, Snyder EL, el-Deiry WS, Brachmann RK | title = hADA3 is required for p53 activity | journal = The EMBO Journal | volume = 20 | issue = 22 | pages = 6404–13 | date = Nov 2001 | pmid = 11707411 | pmc = 125723 | doi = 10.1093/emboj/20.22.6404 }}</ref> and [[Myc]].<ref name=pmid12660246>{{cite journal | vauthors = Liu X, Tesfai J, Evrard YA, Dent SY, Martinez E | title = c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation | journal = The Journal of Biological Chemistry | volume = 278 | issue = 22 | pages = 20405–12 | date = May 2003 | pmid = 12660246 | pmc = 4031917 | doi = 10.1074/jbc.M211795200 }}</ref>
{{WikiDoc Sources}}
 
== References ==
{{Reflist}}
 
== Further reading ==
{{Refbegin | 2}}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
* {{cite journal | vauthors = Wang L, Mizzen C, Ying C, Candau R, Barlev N, Brownell J, Allis CD, Berger SL | title = Histone acetyltransferase activity is conserved between yeast and human GCN5 and is required for complementation of growth and transcriptional activation | journal = Molecular and Cellular Biology | volume = 17 | issue = 1 | pages = 519–27 | date = Jan 1997 | pmid = 8972232 | pmc = 231776 | doi =  10.1128/mcb.17.1.519}}
* {{cite journal | vauthors = Carter KC, Wang L, Shell BK, Zamir I, Berger SL, Moore PA | title = The human transcriptional adaptor genes TADA2L and GCN5L2 colocalize to chromosome 17q12-q21 and display a similar tissue expression pattern | journal = Genomics | volume = 40 | issue = 3 | pages = 497–500 | date = Mar 1997 | pmid = 9073520 | doi = 10.1006/geno.1996.4605 }}
* {{cite journal | vauthors = Henriksson A, Almlöf T, Ford J, McEwan IJ, Gustafsson JA, Wright AP | title = Role of the Ada adaptor complex in gene activation by the glucocorticoid receptor | journal = Molecular and Cellular Biology | volume = 17 | issue = 6 | pages = 3065–73 | date = Jun 1997 | pmid = 9154805 | pmc = 232159 | doi =  10.1128/mcb.17.6.3065}}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
* {{cite journal | vauthors = Ogryzko VV, Kotani T, Zhang X, Schiltz RL, Howard T, Yang XJ, Howard BH, Qin J, Nakatani Y | title = Histone-like TAFs within the PCAF histone acetylase complex | journal = Cell | volume = 94 | issue = 1 | pages = 35–44 | date = Jul 1998 | pmid = 9674425 | doi = 10.1016/S0092-8674(00)81219-2 }}
* {{cite journal | vauthors = Vassilev A, Yamauchi J, Kotani T, Prives C, Avantaggiati ML, Qin J, Nakatani Y | title = The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily | journal = Molecular Cell | volume = 2 | issue = 6 | pages = 869–75 | date = Dec 1998 | pmid = 9885574 | doi = 10.1016/S1097-2765(00)80301-9 }}
* {{cite journal | vauthors = Wang T, Kobayashi T, Takimoto R, Denes AE, Snyder EL, el-Deiry WS, Brachmann RK | title = hADA3 is required for p53 activity | journal = The EMBO Journal | volume = 20 | issue = 22 | pages = 6404–13 | date = Nov 2001 | pmid = 11707411 | pmc = 125723 | doi = 10.1093/emboj/20.22.6404 }}
* {{cite journal | vauthors = Barlev NA, Emelyanov AV, Castagnino P, Zegerman P, Bannister AJ, Sepulveda MA, Robert F, Tora L, Kouzarides T, Birshtein BK, Berger SL | title = A novel human Ada2 homologue functions with Gcn5 or Brg1 to coactivate transcription | journal = Molecular and Cellular Biology | volume = 23 | issue = 19 | pages = 6944–57 | date = Oct 2003 | pmid = 12972612 | pmc = 193946 | doi = 10.1128/MCB.23.19.6944-6957.2003 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
* {{cite journal | vauthors = Qian C, Zhang Q, Li S, Zeng L, Walsh MJ, Zhou MM | title = Structure and chromosomal DNA binding of the SWIRM domain | journal = Nature Structural & Molecular Biology | volume = 12 | issue = 12 | pages = 1078–85 | date = Dec 2005 | pmid = 16299514 | doi = 10.1038/nsmb1022 }}
{{Refend}}
 
{{PDB Gallery|geneid=6871}}

Latest revision as of 15:41, 8 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

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Ensembl

n/a

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UniProt

n/a

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RefSeq (mRNA)

n/a

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Transcriptional adapter 2-alpha is a protein that in humans is encoded by the TADA2A gene.[1][2]

Function

Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Two transcript variants encoding different isoforms have been identified for this gene.[2]

Interactions

TADA2L has been shown to interact with GCN5L2,[3][4] TADA3L[5][6] and Myc.[7]

References

  1. ↑ Candau R, Moore PA, Wang L, Barlev N, Ying CY, Rosen CA, Berger SL (Feb 1996). "Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5". Molecular and Cellular Biology. 16 (2): 593–602. doi:10.1128/mcb.16.2.593. PMC 231038. PMID 8552087.
  2. ↑ 2.0 2.1 "Entrez Gene: TADA2L transcriptional adaptor 2 (ADA2 homolog, yeast)-like".
  3. ↑ Barlev NA, Poltoratsky V, Owen-Hughes T, Ying C, Liu L, Workman JL, Berger SL (Mar 1998). "Repression of GCN5 histone acetyltransferase activity via bromodomain-mediated binding and phosphorylation by the Ku-DNA-dependent protein kinase complex". Molecular and Cellular Biology. 18 (3): 1349–58. doi:10.1128/mcb.18.3.1349. PMC 108848. PMID 9488450.
  4. ↑ Wang L, Mizzen C, Ying C, Candau R, Barlev N, Brownell J, Allis CD, Berger SL (Jan 1997). "Histone acetyltransferase activity is conserved between yeast and human GCN5 and is required for complementation of growth and transcriptional activation". Molecular and Cellular Biology. 17 (1): 519–27. doi:10.1128/mcb.17.1.519. PMC 231776. PMID 8972232.
  5. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  6. ↑ Wang T, Kobayashi T, Takimoto R, Denes AE, Snyder EL, el-Deiry WS, Brachmann RK (Nov 2001). "hADA3 is required for p53 activity". The EMBO Journal. 20 (22): 6404–13. doi:10.1093/emboj/20.22.6404. PMC 125723. PMID 11707411.
  7. ↑ Liu X, Tesfai J, Evrard YA, Dent SY, Martinez E (May 2003). "c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation". The Journal of Biological Chemistry. 278 (22): 20405–12. doi:10.1074/jbc.M211795200. PMC 4031917. PMID 12660246.

Further reading

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