Squamous cell carcinoma of the skin risk factors: Difference between revisions

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Common risk factors for the development of the disease inlcude:
Common risk factors for the development of the disease inlcude:


* Chronic sun exposure.
* UV light exposure
* Fair skin
** UV light damages DNA, initiating a series of changes can result in malignant transformation
* Elderly age (>45 yrs)
* Having skin that burns easily and does not tan or tans poorly
* Male sex
* Light-colored hair
* Older age
* Smoking
* Smoking


=== Less Common Risk factors ===
=== Less Common Risk factors ===


* Previous history of a skin cancer.
* Northern European ancestry
* [[Xeroderma Pigmentosa]]
* Exposure to PUVA phototherapy
* Drugs that cause photo-sensitivity like [[ibuprofen]], [[isotretinoin]] etc.,
* Immunosuppressive treatment
* Immuno suppression in post-transplantation patients
* Exposure to ionizing radiation and other industrial carcinogens
* Skin inflammation or injury.
* Chronic inflammation
* Rare inherited disorders
** Xeroderma pigmentosum
** Epidermolysis bullosa
** Albinism
** Epidermodysplasia verruciformis
** Fanconi's anemia
* Arsenic exposure
* Genetic alterations
* Family history
* Drugs
** BRAF inhibitors
** Voriconazole
** Other photosensitizing drugs like [[ibuprofen]] and [[isotretinoin]]


==References==
==References==

Revision as of 21:54, 22 May 2019

Squamous cell carcinoma of the skin Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aditya Govindavarjhulla, M.B.B.S. [2], Raviteja Guddeti, M.B.B.S. [3]

Overview

The risk factors for the Squamous cell carcinoma (SCC) include prolonged sunlight exposure, UV radiation, smoking, drugs etc.

Risk Factors

Common Risk Factors

Common risk factors for the development of the disease inlcude:

  • UV light exposure
    • UV light damages DNA, initiating a series of changes can result in malignant transformation
  • Having skin that burns easily and does not tan or tans poorly
  • Light-colored hair
  • Older age
  • Smoking

Less Common Risk factors

  • Northern European ancestry
  • Exposure to PUVA phototherapy
  • Immunosuppressive treatment
  • Exposure to ionizing radiation and other industrial carcinogens
  • Chronic inflammation
  • Rare inherited disorders
    • Xeroderma pigmentosum
    • Epidermolysis bullosa
    • Albinism
    • Epidermodysplasia verruciformis
    • Fanconi's anemia
  • Arsenic exposure
  • Genetic alterations
  • Family history
  • Drugs

References


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