Squamous cell carcinoma of the skin diagnostic study of choice

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Squamous cell carcinoma of the skin Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Roukoz A. Karam, M.D.[2]

Overview

A biopsy is the gold standard test for the diagnosis of squamous cell carcinoma of the skin.

Diagnostic Study of Choice

Study of choice

A biopsy is the gold standard test for the diagnosis of squamous cell carcinoma of the skin.[1]

Although clinical findings may strongly suggest a diagnosis of cutaneous squamous cell carcinoma, histopathologic examination is necessary to confirm the diagnosis.

Histopathologic examination is also useful for assessment for perineural invasion, tumor differentiation, and tumor depth, factors that are important for tumor staging and prognosis.[1]

  • Shave, punch, or excisional biopsies may be used for diagnosis.

Staging

Staging of squamous cell carcinoma of the skin based on the AJCC recommendations:[2]

Cutaneous Squamous cell carcinoma
Grouping TNM staging
Stage 0 Tis N0 M0
Stage I T1 N0 M0
Stage II T2 N0 M0
Stage III T3 N0 M0
T1 N1 M0
T2 N1 M0
T3 N1 M0
Stage IV T1 N2 M0
T2 N2 M0
T3 N2 M0
Any T N3 M0
T4 Any N M0
Any T Any N M1

For information on the TNM classification of squamous cell carcinoma of the skin, click here.

References

  1. 1.0 1.1 Prieto-Granada C, Rodriguez-Waitkus P (2015). "Cutaneous squamous cell carcinoma and related entities: Epidemiology, clinical and histological features, and basic science overview". Curr Probl Cancer. 39 (4): 206–15. doi:10.1016/j.currproblcancer.2015.07.005. PMID 26239204.
  2. Jambusaria-Pahlajani A, Kanetsky PA, Karia PS, Hwang WT, Gelfand JM, Whalen FM; et al. (2013). "Evaluation of AJCC tumor staging for cutaneous squamous cell carcinoma and a proposed alternative tumor staging system". JAMA Dermatol. 149 (4): 402–10. doi:10.1001/jamadermatol.2013.2456. PMID 23325457.

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