Spondyloarthropathy causes: Difference between revisions
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! colspan="7" style="background: #ff8c00; width: 800px:" | {{fontcolor|#FFF|Overview of the locus, gene, and function of definite and probable genetic risk factors for SpA}} | ! colspan="7" style="background: #ff8c00; width: 800px:" | {{fontcolor|#FFF|Overview of the locus, gene, and function of definite and probable genetic risk factors for SpA}} | ||
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! rowspan="2" style="background: #1e90ff; width: 200px;" | {{fontcolor|#FFF| | ! rowspan="2" style="background: #1e90ff; width: 200px;" | {{fontcolor|#FFF|Locus}} | ||
! rowspan="2" style="background: #1e90ff; width: 200px;" | {{fontcolor|#FFF|Gene}} | ! rowspan="2" style="background: #1e90ff; width: 200px;" | {{fontcolor|#FFF|Gene}} | ||
! rowspan="2" style="background: #1e90ff; width: 200px;" | {{fontcolor|#FFF|Function}} | ! rowspan="2" style="background: #1e90ff; width: 200px;" | {{fontcolor|#FFF|Function}} | ||
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Revision as of 21:42, 28 August 2018
causes
Albiet, all the progresses have been made through investigating the cause of spondyloarthropathies, the exact cause of this disease remained unclear, however, the role of genetic have been seen through numerous studies have been made in this field of study. Studies demonstrated the role of HLA-B27 in the occurrence of spondyloarthropathies.
Here are some locus, gene, and function of definite and probable genetic risk factors for SpA.
| Overview of the locus, gene, and function of definite and probable genetic risk factors for SpA | ||||||
|---|---|---|---|---|---|---|
| Locus | Gene | Function | Association with | |||
| Ankylosing spondylitis | Psoriasis | Inflammatory bowel disease | ||||
| 6p21.3 | HLA-B27 | Antigene presentation | Yes | .. | .. | |
| 5q15 | ERAP1 | Aminopeptidase | Yes | Probable | .. | |
| 1p31.2 | IL23R | Cytokine receptor | Yes | Yes | Yes | |
| 2p15 | .. | .. | Yes | .. | .. | |
| 21q22 | .. | .. | Yes | .. | .. | |
| 12p13.2 | TNFRSF1A | Cytokine receptor | Probable | .. | Yes | |
| 16q22 | TRADD | Signaling | Probable | .. | .. | |
| 9q32 | TNFSF15 | Inflammatory cytokine | Probable | .. | Yes | |
| 2q14 | IL1A | Inflammatory cytokine | Probable | .. | .. | |
| 2q12 | IL1R2 | Cytokine receptor | Probable | .. | .. | |
| 9q34 | CARD9 | Innate immune defence | Probable | .. | .. | |
| 4q21.1 | ANTXR2 | Vascular morphogenesis | Probable | .. | .. | |