Splenic marginal zone lymphoma surgery: Difference between revisions
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The feasibility of surgery depends on the stage of splenic marginal zone lymphoma at diagnosis. | The feasibility of surgery depends on the stage of splenic marginal zone lymphoma at diagnosis. | ||
==Surgery== | ==Surgery== | ||
* Splenectomy has been performed for the treatment of splenic marginal zone lymphoma (SMZL) over the years with a good success rate and may be delayed until the patient become symptomatic or develop cytopenia.<ref name="pmid12141954">{{cite journal |vauthors=Thieblemont C, Felman P, Berger F, Dumontet C, Arnaud P, Hequet O, Arcache J, Callet-Bauchu E, Salles G, Coiffier B |title=Treatment of splenic marginal zone B-cell lymphoma: an analysis of 81 patients |journal=Clin Lymphoma |volume=3 |issue=1 |pages=41–7 |date=June 2002 |pmid=12141954 |doi= |url=}}</ref><ref name="pmid23840125">{{cite journal |vauthors=Wu Z, Zhou J, Wang X, Li YB, Niu T, Peng B |title=Laparoscopic splenectomy for treatment of splenic marginal zone lymphoma |journal=World J. Gastroenterol. |volume=19 |issue=24 |pages=3854–60 |date=June 2013 |pmid=23840125 |pmc=3699034 |doi=10.3748/wjg.v19.i24.3854 |url=}}</ref> | * Splenectomy has been performed for the treatment of splenic marginal zone lymphoma (SMZL) over the years with a good success rate and may be delayed until the patient become symptomatic or develop cytopenia.<ref name="pmid12141954">{{cite journal |vauthors=Thieblemont C, Felman P, Berger F, Dumontet C, Arnaud P, Hequet O, Arcache J, Callet-Bauchu E, Salles G, Coiffier B |title=Treatment of splenic marginal zone B-cell lymphoma: an analysis of 81 patients |journal=Clin Lymphoma |volume=3 |issue=1 |pages=41–7 |date=June 2002 |pmid=12141954 |doi= |url=}}</ref><ref name="pmid23840125">{{cite journal |vauthors=Wu Z, Zhou J, Wang X, Li YB, Niu T, Peng B |title=Laparoscopic splenectomy for treatment of splenic marginal zone lymphoma |journal=World J. Gastroenterol. |volume=19 |issue=24 |pages=3854–60 |date=June 2013 |pmid=23840125 |pmc=3699034 |doi=10.3748/wjg.v19.i24.3854 |url=}}</ref><ref name="pmid17680218">{{cite journal |vauthors=Matutes E |title=Splenic marginal zone lymphoma with and without villous lymphocytes |journal=Curr Treat Options Oncol |volume=8 |issue=2 |pages=109–16 |date=April 2007 |pmid=17680218 |doi=10.1007/s11864-007-0026-0 |url=}}</ref> | ||
* Response to splenectomy is partial as lymphocytosis and bone marrow infiltration persists.<ref name="pmid11180074">{{cite journal |vauthors=Franco V, Florena AM, Stella M, Rizzo A, Iannitto E, Quintini G, Campesi G |title=Splenectomy influences bone marrow infiltration in patients with splenic marginal zone cell lymphoma with or without villous lymphocytes |journal=Cancer |volume=91 |issue=2 |pages=294–301 |date=January 2001 |pmid=11180074 |doi= |url=}}</ref><ref name="pmid26989207">{{cite journal |vauthors=Arcaini L, Rossi D, Paulli M |title=Splenic marginal zone lymphoma: from genetics to management |journal=Blood |volume=127 |issue=17 |pages=2072–81 |date=April 2016 |pmid=26989207 |doi=10.1182/blood-2015-11-624312 |url=}}</ref> | * Response to splenectomy is partial as lymphocytosis and bone marrow infiltration persists.<ref name="pmid11180074">{{cite journal |vauthors=Franco V, Florena AM, Stella M, Rizzo A, Iannitto E, Quintini G, Campesi G |title=Splenectomy influences bone marrow infiltration in patients with splenic marginal zone cell lymphoma with or without villous lymphocytes |journal=Cancer |volume=91 |issue=2 |pages=294–301 |date=January 2001 |pmid=11180074 |doi= |url=}}</ref><ref name="pmid26989207">{{cite journal |vauthors=Arcaini L, Rossi D, Paulli M |title=Splenic marginal zone lymphoma: from genetics to management |journal=Blood |volume=127 |issue=17 |pages=2072–81 |date=April 2016 |pmid=26989207 |doi=10.1182/blood-2015-11-624312 |url=}}</ref> | ||
* Splenectomy has been used alone as well as in combination with chemotherapy regime for the treatment but no difference of overall survival benefit was found between the two therapeutic modalities.<ref name="pmid19705496">{{cite journal |vauthors=Milosevic R, Todorovic M, Balint B, Jevtic M, Krstic M, Ristanovic E, Antonijevic N, Pavlovic M, Perunicic M, Petrovic M, Mihaljevic B |title=Splenectomy with chemotherapy vs surgery alone as initial treatment for splenic marginal zone lymphoma |journal=World J. Gastroenterol. |volume=15 |issue=32 |pages=4009–15 |date=August 2009 |pmid=19705496 |pmc=2731951 |doi= |url=}}</ref> | * Splenectomy has been used alone as well as in combination with chemotherapy regime for the treatment but no difference of overall survival benefit was found between the two therapeutic modalities.<ref name="pmid19705496">{{cite journal |vauthors=Milosevic R, Todorovic M, Balint B, Jevtic M, Krstic M, Ristanovic E, Antonijevic N, Pavlovic M, Perunicic M, Petrovic M, Mihaljevic B |title=Splenectomy with chemotherapy vs surgery alone as initial treatment for splenic marginal zone lymphoma |journal=World J. Gastroenterol. |volume=15 |issue=32 |pages=4009–15 |date=August 2009 |pmid=19705496 |pmc=2731951 |doi= |url=}}</ref> | ||
Revision as of 22:02, 1 January 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overview
The feasibility of surgery depends on the stage of splenic marginal zone lymphoma at diagnosis.
Surgery
- Splenectomy has been performed for the treatment of splenic marginal zone lymphoma (SMZL) over the years with a good success rate and may be delayed until the patient become symptomatic or develop cytopenia.[1][2][3]
- Response to splenectomy is partial as lymphocytosis and bone marrow infiltration persists.[4][5]
- Splenectomy has been used alone as well as in combination with chemotherapy regime for the treatment but no difference of overall survival benefit was found between the two therapeutic modalities.[6]
- Splenectomy on the other hand is considered to be a better option than chemotherapy alone.[7]
- There is perioperative risk associated with splenectomy
References
- ↑ Thieblemont C, Felman P, Berger F, Dumontet C, Arnaud P, Hequet O, Arcache J, Callet-Bauchu E, Salles G, Coiffier B (June 2002). "Treatment of splenic marginal zone B-cell lymphoma: an analysis of 81 patients". Clin Lymphoma. 3 (1): 41–7. PMID 12141954.
- ↑ Wu Z, Zhou J, Wang X, Li YB, Niu T, Peng B (June 2013). "Laparoscopic splenectomy for treatment of splenic marginal zone lymphoma". World J. Gastroenterol. 19 (24): 3854–60. doi:10.3748/wjg.v19.i24.3854. PMC 3699034. PMID 23840125.
- ↑ Matutes E (April 2007). "Splenic marginal zone lymphoma with and without villous lymphocytes". Curr Treat Options Oncol. 8 (2): 109–16. doi:10.1007/s11864-007-0026-0. PMID 17680218.
- ↑ Franco V, Florena AM, Stella M, Rizzo A, Iannitto E, Quintini G, Campesi G (January 2001). "Splenectomy influences bone marrow infiltration in patients with splenic marginal zone cell lymphoma with or without villous lymphocytes". Cancer. 91 (2): 294–301. PMID 11180074.
- ↑ Arcaini L, Rossi D, Paulli M (April 2016). "Splenic marginal zone lymphoma: from genetics to management". Blood. 127 (17): 2072–81. doi:10.1182/blood-2015-11-624312. PMID 26989207.
- ↑ Milosevic R, Todorovic M, Balint B, Jevtic M, Krstic M, Ristanovic E, Antonijevic N, Pavlovic M, Perunicic M, Petrovic M, Mihaljevic B (August 2009). "Splenectomy with chemotherapy vs surgery alone as initial treatment for splenic marginal zone lymphoma". World J. Gastroenterol. 15 (32): 4009–15. PMC 2731951. PMID 19705496.
- ↑ Parry-Jones N, Matutes E, Gruszka-Westwood AM, Swansbury GJ, Wotherspoon AC, Catovsky D (March 2003). "Prognostic features of splenic lymphoma with villous lymphocytes: a report on 129 patients". Br. J. Haematol. 120 (5): 759–64. PMID 12614206.