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{{Splenic marginal zone lymphoma}}
{{Splenic marginal zone lymphoma}}
{{CMG}}, {{AE}} {{AS}}
{{CMG}}, {{AE}} {{Affan}} {{AE}} {{AS}}
==Overview==
==Overview==
[[Splenectomy]] was considered to be the 1st line treatment option for [[splenic marginal zone lymphoma]] ([[SMZL]]) but recent studies have shown that [[rituximab]] is equally effective if not better treatment option in terms of overall survival. [[Splenectomy]] is still performed but mainly in patients with [[splenomegaly]] without [[lymphadenopathy]] having low surgical risk or in those who are refractory to [[rituximab]] therapy.
[[Splenectomy]] was considered to be the 1st line treatment option for [[splenic marginal zone lymphoma]] ([[SMZL]]) but recent studies have shown that [[rituximab]] is equally effective if not better treatment option in terms of overall survival. [[Splenectomy]] is still performed but mainly in patients with [[splenomegaly]] without [[lymphadenopathy]] having low surgical risk or in those who are refractory to [[rituximab]] therapy.

Revision as of 06:27, 17 January 2019

Splenic marginal zone lymphoma Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Associate Editor(s)-in-Chief: Muhammad Affan M.D.[2] Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [3]

Overview

Splenectomy was considered to be the 1st line treatment option for splenic marginal zone lymphoma (SMZL) but recent studies have shown that rituximab is equally effective if not better treatment option in terms of overall survival. Splenectomy is still performed but mainly in patients with splenomegaly without lymphadenopathy having low surgical risk or in those who are refractory to rituximab therapy.

Surgery

References

  1. Thieblemont C, Felman P, Berger F, Dumontet C, Arnaud P, Hequet O, Arcache J, Callet-Bauchu E, Salles G, Coiffier B (June 2002). "Treatment of splenic marginal zone B-cell lymphoma: an analysis of 81 patients". Clin Lymphoma. 3 (1): 41–7. PMID 12141954.
  2. Wu Z, Zhou J, Wang X, Li YB, Niu T, Peng B (June 2013). "Laparoscopic splenectomy for treatment of splenic marginal zone lymphoma". World J. Gastroenterol. 19 (24): 3854–60. doi:10.3748/wjg.v19.i24.3854. PMC 3699034. PMID 23840125.
  3. Matutes E (April 2007). "Splenic marginal zone lymphoma with and without villous lymphocytes". Curr Treat Options Oncol. 8 (2): 109–16. doi:10.1007/s11864-007-0026-0. PMID 17680218.
  4. Franco V, Florena AM, Stella M, Rizzo A, Iannitto E, Quintini G, Campesi G (January 2001). "Splenectomy influences bone marrow infiltration in patients with splenic marginal zone cell lymphoma with or without villous lymphocytes". Cancer. 91 (2): 294–301. PMID 11180074.
  5. Arcaini L, Rossi D, Paulli M (April 2016). "Splenic marginal zone lymphoma: from genetics to management". Blood. 127 (17): 2072–81. doi:10.1182/blood-2015-11-624312. PMID 26989207.
  6. Xing KH, Kahlon A, Skinnider BF, Connors JM, Gascoyne RD, Sehn LH, Savage KJ, Slack GW, Shenkier TN, Klasa R, Gerrie AS, Villa D (May 2015). "Outcomes in splenic marginal zone lymphoma: analysis of 107 patients treated in British Columbia". Br. J. Haematol. 169 (4): 520–7. doi:10.1111/bjh.13320. PMID 25854936.
  7. Milosevic R, Todorovic M, Balint B, Jevtic M, Krstic M, Ristanovic E, Antonijevic N, Pavlovic M, Perunicic M, Petrovic M, Mihaljevic B (August 2009). "Splenectomy with chemotherapy vs surgery alone as initial treatment for splenic marginal zone lymphoma". World J. Gastroenterol. 15 (32): 4009–15. PMC 2731951. PMID 19705496.
  8. Parry-Jones N, Matutes E, Gruszka-Westwood AM, Swansbury GJ, Wotherspoon AC, Catovsky D (March 2003). "Prognostic features of splenic lymphoma with villous lymphocytes: a report on 129 patients". Br. J. Haematol. 120 (5): 759–64. PMID 12614206.
  9. Kennedy ND, Lê GN, Kelly ME, Harding T, Fadalla K, Winter DC (May 2018). "Surgical management of splenic marginal zone lymphoma". Ir J Med Sci. 187 (2): 343–347. doi:10.1007/s11845-017-1689-6. PMID 29043543.

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