Small cell lymphoma: Difference between revisions

Jump to navigation Jump to search
Line 87: Line 87:
*Patients with small cell lymphoma often appear pale and malnourished.  
*Patients with small cell lymphoma often appear pale and malnourished.  
*Physical examination may be remarkable for:
*Physical examination may be remarkable for:
* [[Pallor]]  
:* [[Pallor]]  
* [[Petechiae]]  
:* [[Petechiae]]  
* Leukemia cutis (infiltration of neoplastic leukocytes or their precursors into the skin resulting in clinically identifiable cutaneous lesions)
:* Leukemia cutis (infiltration of neoplastic leukocytes or their precursors into the skin resulting in clinically identifiable cutaneous lesions)
* Enlarged and palpable [[cervical]] [[lymph node]]s  
:* Enlarged and palpable [[cervical]] [[lymph node]]s  
* [[Dacryoadenitis]]
:* [[Dacryoadenitis]]


=== Laboratory Findings ===
=== Laboratory Findings ===

Revision as of 21:02, 3 May 2016

WikiDoc Resources for Small cell lymphoma

Articles

Most recent articles on Small cell lymphoma

Most cited articles on Small cell lymphoma

Review articles on Small cell lymphoma

Articles on Small cell lymphoma in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Small cell lymphoma

Images of Small cell lymphoma

Photos of Small cell lymphoma

Podcasts & MP3s on Small cell lymphoma

Videos on Small cell lymphoma

Evidence Based Medicine

Cochrane Collaboration on Small cell lymphoma

Bandolier on Small cell lymphoma

TRIP on Small cell lymphoma

Clinical Trials

Ongoing Trials on Small cell lymphoma at Clinical Trials.gov

Trial results on Small cell lymphoma

Clinical Trials on Small cell lymphoma at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Small cell lymphoma

NICE Guidance on Small cell lymphoma

NHS PRODIGY Guidance

FDA on Small cell lymphoma

CDC on Small cell lymphoma

Books

Books on Small cell lymphoma

News

Small cell lymphoma in the news

Be alerted to news on Small cell lymphoma

News trends on Small cell lymphoma

Commentary

Blogs on Small cell lymphoma

Definitions

Definitions of Small cell lymphoma

Patient Resources / Community

Patient resources on Small cell lymphoma

Discussion groups on Small cell lymphoma

Patient Handouts on Small cell lymphoma

Directions to Hospitals Treating Small cell lymphoma

Risk calculators and risk factors for Small cell lymphoma

Healthcare Provider Resources

Symptoms of Small cell lymphoma

Causes & Risk Factors for Small cell lymphoma

Diagnostic studies for Small cell lymphoma

Treatment of Small cell lymphoma

Continuing Medical Education (CME)

CME Programs on Small cell lymphoma

International

Small cell lymphoma en Espanol

Small cell lymphoma en Francais

Business

Small cell lymphoma in the Marketplace

Patents on Small cell lymphoma

Experimental / Informatics

List of terms related to Small cell lymphoma

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]

Synonyms and keywords: SLL

Overview

Small cell lymphoma (also known as SLL) is a type of mature B-cell chronic lymphocytic leukemia that presents primarily in the lymph nodes.

Historical Perspective

  • Small cell lymphoma was first discovered by Dr. George Minot, an American physician, in 1924.[1]

Classification

  • Small cell lymphoma may be classified according to [classification method] into [number] subtypes/groups:
  • [group1]
  • [group2]
  • [group3]
  • Other variants of small cell lymphoma include [disease subtype 1], [disease subtype 2], and [disease subtype 3].

Pathophysiology

  • The pathogenesis of small cell lymphoma is characterized by the malignant infiltration of lymphocytic cells into the bone marrow, where they interfere with the production of red blood cells and platelets.
  • Small cell lymphoma arises from pre-follicular center B cells that are normally involved in the process of human immunoglobulins production.
  • Genes involved in the development of small cell lymphoma, include:
  • On gross pathology, characteristic findings of small cell lymphoma, include:
  • No remarkable findings
  • On microscopic histopathological analysis, characteristic findings of small cell lymphoma, include:

Causes

  • There are no established causes for small cell lymphoma.

Differentiating Small Cell Lymphoma from Other Diseases

  • Small cell lymphoma must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as:
  • [Differential dx1
  • [Differential dx2]
  • [Differential dx3]

Epidemiology and Demographics

  • The prevalence of small cell lymphoma is low.
  • Small cell lymphoma represents 90 % of all B-cell chronic lymphocytic leukemias in the United States.

Age

  • Patients of all age groups may develop small cell lymphoma.
  • Small cell lymphoma is more commonly observed among patients aged [age range] years old.
  • Small cell lymphoma is more commonly observed among [elderly patients/young patients/children].

Gender

  • Males are more commonly affected with small cell lymphoma than females.

Race

  • There is no racial predilection for small cell lymphoma.

Risk Factors

  • Common risk factors in the development of small cell lymphoma are [risk factor 1], [risk factor 2], [risk factor 3], and [risk factor 4].

Natural History, Complications and Prognosis

  • The majority of patients with small cell lymphoma are symptomatic at the time of diagnosis.
  • Early clinical features include
  • If left untreated, patients with small cell lymphoma may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
  • Common complications of small cell lymphoma, include:
  • Prognosis is generally poor, and the 5-year survival rate of patients with small cell lymphoma is approximately

Diagnosis

Symptoms

  • Symptoms of small cell lymphoma may include the following:

Physical Examination

  • Patients with small cell lymphoma often appear pale and malnourished.
  • Physical examination may be remarkable for:

Laboratory Findings

  • Laboratory findings consistent with the diagnosis of small cell lymphoma, include:

Imaging Findings

  • There are no [imaging study] findings associated with small cell lymphoma.
  • [Imaging study 1] is the imaging modality of choice for small cell lymphoma.
  • On [imaging study 1], small cell lymphoma is characterized by [finding 1], [finding 2], and [finding 3].
  • [Imaging study 2] may demonstrate [finding 1], [finding 2], and [finding 3].

Treatment

Medical Therapy

  • There is no treatment for small cell lymphoma; the mainstay of therapy is supportive care.
  • The mainstay of therapy for small cell lymphoma is [medical therapy 1] and [medical therapy 2].
  • [Medical therapy 1] acts by [mechanism of action1].
  • Response to [medical therapy 1] can be monitored with [test/physical finding/imaging] every [frequency/duration].

Surgery

  • Surgery is the mainstay of therapy for small cell lymphoma.
  • [Surgical procedure] in conjunction with [chemotherapy/radiation] is the most common approach to the treatment of small cell lymphoma.
  • [Surgical procedure] can only be performed for patients with [disease stage] small cell lymphoma.

Prevention

  • There are no primary preventive measures available for small cell lymphoma.
  • Effective measures for the primary prevention of small cell lymphoma include [measure1], [measure2], and [measure3].
  • Once diagnosed and successfully treated, patients with small cell lymphoma are followed-up every [duration]. Follow-up testing includes [test 1], [test 2], and [test 3].

References

  1. Rai KR (1993). "Progress in chronic lymphocytic leukaemia: a historical perspective". Baillieres Clin Haematol. 6 (4): 757–65. PMID 8038488.