Sickle-cell disease risk factors: Difference between revisions

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==Overview==
The most potent risk factor in the development of sickle-cell disease is race.


==Risk Factors==
==Risk Factors==
Besides race, there are no specific risk factors for sickle cell disease. Sickle cell disease is a monogenetic disease, meaning that one gene mutations causes the disease. Thus environmental factors do not play a major role in acquisition of the disease. The disease occurs at birth after a person inherits 2 sickle cell alleles, one from each parent. Certain endemic regions contain a high prevalence of sickle cell alleles.<ref name="pmid25143960">{{cite journal| author=Makani J, Ofori-Acquah SF, Nnodu O, Wonkam A, Ohene-Frempong K| title=Sickle cell disease: new opportunities and challenges in Africa. | journal=ScientificWorldJournal | year= 2013 | volume= 2013 | issue=  | pages= 193252 | pmid=25143960 | doi=10.1155/2013/193252 | pmc=3988892 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25143960  }} </ref>
===Common Risk Factors===
 
*Common risk factors in the development of sickle-cell disease include:<ref name="pmid25143960">{{cite journal| author=Makani J, Ofori-Acquah SF, Nnodu O, Wonkam A, Ohene-Frempong K| title=Sickle cell disease: new opportunities and challenges in Africa. | journal=ScientificWorldJournal | year= 2013 | volume= 2013 | issue=  | pages= 193252 | pmid=25143960 | doi=10.1155/2013/193252 | pmc=3988892 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25143960  }} </ref><ref name="pmid22099364">{{cite journal |vauthors=Grosse SD, Odame I, Atrash HK, Amendah DD, Piel FB, Williams TN |title=Sickle cell disease in Africa: a neglected cause of early childhood mortality |journal=Am J Prev Med |volume=41 |issue=6 Suppl 4 |pages=S398–405 |date=December 2011 |pmid=22099364 |pmc=3708126 |doi=10.1016/j.amepre.2011.09.013 |url=}}</ref>
There are some risk factors for precipitation of sickle cell crises, such as dehydration, low oxygen levels, medication nonadherence.
** Africans
**African Americans
**Indians
**Mediterranean descent
**Geographic location


==References==
==References==
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{{reflist|2}}
[[Category:Hematology]]
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Latest revision as of 15:14, 1 August 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shyam Patel [2]

Overview

The most potent risk factor in the development of sickle-cell disease is race.

Risk Factors

Common Risk Factors

  • Common risk factors in the development of sickle-cell disease include:[1][2]
    • Africans
    • African Americans
    • Indians
    • Mediterranean descent
    • Geographic location

References

  1. Makani J, Ofori-Acquah SF, Nnodu O, Wonkam A, Ohene-Frempong K (2013). "Sickle cell disease: new opportunities and challenges in Africa". ScientificWorldJournal. 2013: 193252. doi:10.1155/2013/193252. PMC 3988892. PMID 25143960.
  2. Grosse SD, Odame I, Atrash HK, Amendah DD, Piel FB, Williams TN (December 2011). "Sickle cell disease in Africa: a neglected cause of early childhood mortality". Am J Prev Med. 41 (6 Suppl 4): S398–405. doi:10.1016/j.amepre.2011.09.013. PMC 3708126. PMID 22099364.